7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1 Purity >99.0% (GC) Agomelatine Intermediate

Whakaahuatanga Poto:

Ingoa: 7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester

Nga kupu taurite: Ethyl 2-(7-Methoxynaphthalen-1-yl)acetate

CAS: 6836-21-1

Parakore: >99.0% (GC)

Te ahua: Kowhai Maamaa Te Wai Puata

Takawaenga o Agomelatine (CAS: 138112-76-2)

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Taipitopito Hua

Hua e Pa ana

Tohu Hua

Whakaahuatanga:

Kaihanga Kaihanga me te Kaiwhakarato o Agomelatine Intermediates
Agomelatine CAS 138112-76-2
7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
Please contact: alvin@ruifuchem.com

Ngā Āhuatanga matū:

Ingoa matū 7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester
Nga kupu taurite Ethyl 2-(7-Methoxynaphthalen-1-yl)acetate
Tau CAS 6836-21-1
Tau CAT RF2687
Tūnga Taonga I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi C15H16O3
Taumaha rāpoi 244.29
Waitohu Ruifu Chemical

Whakatakotoranga:

Tūemi Whakatakotoranga
Te ahua Kowhai Maama Puata Wai
Te Maama / Tikanga Tatauria >99.0% (GC)
Wai (na Karl Fischer) <0.50%
Nga Taonga Paanga <1.00%
Spectrum Infrared He rite ki te Hanganga
NMR Spectrum He rite ki te Hanganga
Paerewa Whakamatau Paerewa hinonga
Whakamahinga Takawaenga Rongoa o Agomelatine (CAS: 138112-76-2)

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Taupānga:

Ko te 7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester (CAS: 6836-21-1) he takawaenga waihanga pararopi whai hua, ka taea te whakamahi hei takawaenga rongoa o Agomelatine (CAS: 138112-76-2).Ko Agomelatine, he mea whakawhanakehia e te kamupene French Servier, ko te kaikawe melatonin tuatahi o te ao MT1 me te MT2 agonist class o antidepressants.E pa ana ki te maimoatanga o nga turoro pakeke me te pouri nui.Ko te Agomelatine he rongoa whakaheke.Ko te Agomelatine he agonist o nga kaiwhakawhiwhi melatonin (MT) me te whakaputanga o te melatonin.Ka herea ki nga kaiwhakawhiwhi MT1 me MT2 (Kis = 0.14 me te 0.41 nM, ia) me te uara EC50 o 0.1 nM i roto i te [35S]GTPγS ma te whakamahi i nga pūtau CHO e whakaatu ana i nga kaiwhakawhiwhi MT2.Kei te whakarōpūhia he norepinephrine-dopamine disinhibitor (NDDI) na te kaha o tana whakahē o te kaiwhiwhi 5-HT2C.Ko te whakahoahoatanga o nga kaiwhakawhiwhi 5-HT2C na te serotonin ka aukati i te tuku dopamine me te norepinephrine.

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