7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1 Purity >99.0% (GC) Agomelatine Intermediate
Kaihanga Kaihanga me te Kaiwhakarato o Agomelatine Intermediates
Agomelatine CAS 138112-76-2
7-Methoxy-1-Tetralone CAS 6836-19-7
7-Methoxy-1-Naphthaleneacetic Acid CAS 6836-22-2
7-Methoxy-1-Naphthylacetonitrile CAS 138113-08-3
7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester CAS 6836-21-1
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Ingoa matū | 7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester |
Nga kupu taurite | Ethyl 2-(7-Methoxynaphthalen-1-yl)acetate |
Tau CAS | 6836-21-1 |
Tau CAT | RF2687 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C15H16O3 |
Taumaha rāpoi | 244.29 |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Kowhai Maama Puata Wai |
Te Maama / Tikanga Tatauria | >99.0% (GC) |
Wai (na Karl Fischer) | <0.50% |
Nga Taonga Paanga | <1.00% |
Spectrum Infrared | He rite ki te Hanganga |
NMR Spectrum | He rite ki te Hanganga |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | Takawaenga Rongoa o Agomelatine (CAS: 138112-76-2) |
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Ko te 7-Methoxy-1-Naphthaleneacetic Acid Ethyl Ester (CAS: 6836-21-1) he takawaenga waihanga pararopi whai hua, ka taea te whakamahi hei takawaenga rongoa o Agomelatine (CAS: 138112-76-2).Ko Agomelatine, he mea whakawhanakehia e te kamupene French Servier, ko te kaikawe melatonin tuatahi o te ao MT1 me te MT2 agonist class o antidepressants.E pa ana ki te maimoatanga o nga turoro pakeke me te pouri nui.Ko te Agomelatine he rongoa whakaheke.Ko te Agomelatine he agonist o nga kaiwhakawhiwhi melatonin (MT) me te whakaputanga o te melatonin.Ka herea ki nga kaiwhakawhiwhi MT1 me MT2 (Kis = 0.14 me te 0.41 nM, ia) me te uara EC50 o 0.1 nM i roto i te [35S]GTPγS ma te whakamahi i nga pūtau CHO e whakaatu ana i nga kaiwhakawhiwhi MT2.Kei te whakarōpūhia he norepinephrine-dopamine disinhibitor (NDDI) na te kaha o tana whakahē o te kaiwhiwhi 5-HT2C.Ko te whakahoahoatanga o nga kaiwhakawhiwhi 5-HT2C na te serotonin ka aukati i te tuku dopamine me te norepinephrine.