Afatinib CAS 439081-18-2 Purity >99.5% (HPLC) Factory

Whakaahuatanga Poto:

Ingoa matū: Afatinib

Nga kupu taurite: BIBW2992

CAS: 439081-18-2

Maamaa: >99.5% (HPLC)

Te ahua: Paura-White Paura

E-Mail: alvin@ruifuchem.com

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Taipitopito Hua

Hua e Pa ana

Tohu Hua

Whakaahuatanga:

Ruifu Chemical Supply Takawaenga o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
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trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Waikawa Diethylphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Ngā Āhuatanga matū:

Ingoa matū	Afatinib
Nga kupu taurite	BIBW2992;BIBW-2992;BIBW2992 Paerewa Koreutu;Tomtovok;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(Dimethylamino)engari-2-Enamide
Tau CAS	439081-18-2
Tau CAT	RF-PI2033
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C24H25ClFN5O3
Taumaha rāpoi	485.94
Wairewa	Wairewa i roto i te DMSO
Kiato	1.380
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Paura-Ma
Tautuhinga	HPLC, NMR
Te Maama / Tikanga Tatauria	>99.5% (HPLC)
Iwi Whakarewa	100.0~102.0 ℃
Ngaronga i te whakamaroke	<0.50%
Te toenga i runga i te mura	<0.20%
Nga poke katoa	<0.50%
Nga Korewa Taamaha	≤20ppm
NMR Spectrum	He rite ki te Hanganga
Paerewa Whakamatau	Paerewa hinonga
Te Ora Papa	24 Marama ki te rongoa tika
Whakamahinga	API;Afatinib;Afatinib Dimaleate;NSCLC

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

Painga:

FAQ:

Taupānga:

Ko Afatinib, e mohiotia ana ko BIW-2992, (CAS: 439081-18-2) ko te tuarua-whakatupuranga kaha me te kore e taea te whakakore i te aukati takirua o te epidermal growth factor receptor (EGFR) me te tangata epidermal growth factor receptor 2 (HER2) tyrosine kinase, i whakawhanakehia e Boehringer Ingelheim, Tiamana.Ka taea e ia te aukati i te mahi o te tyrosine kinase ma te mahi i te tauhohenga Michael me te roopu thiol o te cysteine i te waahi 797 o te EGFR.I te Hōngongoi 12, 2013, ka waiho hei rongoa hou mo te mate pukupuku pukupuku pūtau anti-iti i whakaaetia e te US FDA i raro i te ingoa hokohoko o Gilotrif.He papa tenei rongoa.Ka whakamahia mo te maimoatanga o nga turoro e mate ana i te mate pukupuku mate pukupuku pukupuku iti-iti (NSCLC) me te ngaro o te 19th exon, L858R ranei te whakarereketanga i te 21th exon o te pukupuku epidermal growth factor receptor (EGFR) i whakapumautia ma te whakamahi i te kete kua whakaaetia. na FDA.He whai hua ano te rongoa ki te rongoa i nga turoro HER2-pai kua mate pukupuku mate pukupuku.No roto a Afatinib i te karaehe o nga raau taero e mohiotia ana ko te aukati tyrosine kinase.Kua hoahoatia te aukati tyrosine kinase ki te aukati i te mahi a tetahi enzyme motuhake e kiia nei ko tyrosine kinase.Ka whai waahi nui tenei enzyme ki te mahi o nga pūtau, he kaha ki te whakatairanga i te tipu me te haere whakamua.Ka mahi a Afatinib ki te aukati i te mahi o nga momo kinase tyrosine e rua: te kaikawe tauwehe tupu epidermal (EGFR) me te Her2, he mea "nui atu" e te maha o nga momo mate pukupuku.Ma te aukati i te mahi o enei kinase tyrosine, ka aukati pea a Afatinib i nga pūtau mate pukupuku kia kore e wehewehe me te tipu.