Afatinib Dimaleate CAS 850140-73-7 Purity >99.5% (HPLC) API

Whakaahuatanga Poto:

Ingoa matū: Afatinib Dimaleate

Nga kupu taurite: BIBW2992 Dimaleate

CAS: 850140-73-7

Maamaa: >99.0% (HPLC)

Te ahua: Ma ki te Paura-White

API Kounga Teitei, Hanganga Tauhokohoko

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ruifu Chemical Supply Takawaenga o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Waikawa Diethylphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Ngā Āhuatanga matū:

Ingoa matū	Afatinib Dimaleate
Nga kupu taurite	BIBW2992 Dimaleate;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)engari-2-Enamide Dimaleate
Tau CAS	618-89-3
Tau CAT	RF-PI2032
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C32H33ClFN5O11
Taumaha rāpoi	718.08
Te tairongo	Makuku Tairongo
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Ma ki te Paura-White
Te Maama / Tikanga Tatauria	>99.5% (HPLC)
Ngaronga i te whakamaroke	<0.50%
Te toenga i runga i te mura	<0.10%
Mōrahi Kore kotahi	<0.30%
Nga poke katoa	<0.50%
Konga Taamaha (hei Pb)	≤20ppm
Spectrum Infrared	He rite ki te Hanganga
NMR	He rite ki te Hanganga
Paerewa Whakamatau	Paerewa hinonga
Te Ora Papa	24 Marama ki te rongoa tika
Whakamahinga	API

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

Painga:

FAQ:

Taupānga:

Afatinib Dimaleate (CAS: 850140-73-7), te ahua tote dimaleate o afanitib, he kaihoko antineoplastic e waatea ana ki te waha.Ko te Afatinib Dimaleate he kaitautoko whanau EGFR e kore e taea te whakakore me nga IC50s o 0.5 nM, 0.4 nM, 10 nM me 14 nM mo EGFRwt, EGFRL858R, EGFRL858R / T790M me HER2, ia.Ko te Afatinib Dimaleate e tohuhia ana mo te maimoatanga tuatahi mo nga turoro me te mate pukupuku pukupuku pukupuku iti-iti (NSCLC) ko o ratou pukupuku he tango i te epidermal growth factor receptor (EGFR) exon 19 te whakakore, te exon 21 (L858R) ranei nga whakarereketanga whakakapi i kitea e te FDA- whakamatautau kua whakaaetia.I nga wa o mua, ko te maimoatanga paerewa me te tikanga whakamaarama taarua e pa ana ki te konukawata ka kiia ko te rongoa raina tuatahi mo nga turoro katoa me te NSCLC.Heoi ano, kua kitea e nga taunakitanga e puta mai ana nga taupori iti e whai hua ake ai te whakamaaramatanga, e arai ana ki te whakawhanaketanga o nga raau taero rerekee.Afatinib Dimaleate I whakawhanakehia e Boehringer Ingelheim Pharmaceuticals, Afatinib Dimaleate i whakaaetia e te FDA i te 2013 hei tarukino pani i raro i te ingoa hokohoko Gilotrif.Ko te Afatinib Dimaleate ka whakahiatohia ma te whakamahi i nga tikanga paerewa.Afatinib Dimaleateehara i te kaha ki te whakakorikori EGFR e whaaia ana e nga reanga tuatahi o TKI penei i te erlotinib, te gefitinib ranei, engari ano hoki ki nga huringa penei i te T790M kaore e aro ki enei maimoatanga paerewa.Na tana mahi taapiri ki a Her2, kei te whakatewhatewhahia mo te mate pukupuku uma me etahi atu mate pukupuku EGFR me Her2.