Afatinib Dimaleate Intermediate CAS 314771-76-1 Purity >99.0% (HPLC) Factory

Whakaahuatanga Poto:

Ingoa matū: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

CAS: 314771-76-1

Maamaa: >99.0% (HPLC)

Te ahua: Kowhai Maama ki te Paura Kowhai

Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ruifu Chemical Supply Takawaenga o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Waikawa Diethylphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Ngā Āhuatanga matū:

Ingoa matū	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Nga kupu taurite	N4-(3-Chloro-4-Fluorophenyl)-7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;Afatinib poke B;Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl;Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Tau CAS	314771-76-1
Tau CAT	RF-PI2028
Tūnga Taonga	I roto i te Raarangi, Te Whakaputa Whakanui 100MT / Tau
Tātai rāpoi	C18H16ClFN4O2
Taumaha rāpoi	374.8
Kohuatanga	559.0±50.0℃
Kiato	1.473±0.060 g/cm3
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Kowhai Maama ki te Paura Kowhai
Tautuhinga	Ko te Wa Pupuri o te Tumuaki Peak i roto i te HPLC Me Taurite ki te Paerewa
Te Maama / Tikanga Tatauria	>99.0% (HPLC)
Ngaronga i te whakamaroke	<0.50%
Te toenga i runga i te mura	<0.20%
Te poke kotahi	<0.50%
Nga poke katoa	<1.00%
Konga Taamaha (hei Pb)	≤20ppm
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

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Taupānga:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) he takawaenga o Afatinib Dimaleate (CAS: 850140-73-7).Ko te Afatinib te tuarua-whakatupuranga kaha me te kore e taea te whakahoki mai i te aukati takirua o te kaiawhina o te epidermal growth factor receptor (EGFR) me te tangata epidermal growth factor receptor 2 (HER2) tyrosine kinase, i whakawhanakehia e Boehringer Ingelheim, Germany.Ka taea e ia te aukati i te mahi o te tyrosine kinase ma te mahi i te tauhohenga Michael me te roopu thiol o te cysteine i te waahi 797 o te EGFR.Mahi: 1. Ka rite ki te Lapatinib me te Neratinib, ko te Afatinib he aukati kinase pūmua e kore e taea te whakakore i te tangata epidermal growth factor receptor 2 (Her2) me te epidermal growth factor receptor (EGFR) kinases.2. Ko te Afatinib ehara i te kaha ki nga huringa EGFR e whaaia ana e nga TKI whakatipuranga tuatahi penei i te erlotinib, te gefitinib ranei, engari ki nga huringa penei i te T790M karekau e aro ki enei maimoatanga paerewa.Na tana mahi taapiri ki a Her2, kei te whakatewhatewhahia mo te mate pukupuku uma me etahi atu mate pukupuku EGFR me Her2.3. Ko te Afatinib he rongoa mo te maimoatanga rarangi tuatahi o nga turoro me nga momo rereke o te metastatic (EGFR mutation pai) kore-iti iti pūkahukahu pukupuku pukupuku (NSCLC).Ko te mahi hei aukati kovalent e kore e taea te huri o te kaikawe tyrosine kinases epidermal growth factor receptor (EGFR) me te erbB-2 (HER2).