Baloxavir Marboxil CAS 1985606-14-1 API Factory Kounga Teitei

Whakaahuatanga Poto:

Ingoa matū: Baloxavir Marboxil

CAS: 1985606-14-1

Te ahua: Ma ki te Paura-White

Whakatau: 98.0%~102.0%

I roto i te maimoatanga o te rewharewha A me nga mate rewharewha B

Whakapā: Takuta Alvin Huang

Pūkoro/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o Baloxavir Marboxil (CAS: 1985606-14-1) me te kounga teitei.Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hoko Baloxavir Marboxil,Please contact: alvin@ruifuchem.com

Ngā Āhuatanga matū:

Ingoa matū	Baloxavir Marboxil
Nga kupu taurite	BXM;S-033188
Tau CAS	1985606-14-1
Tūnga Taonga	Kei roto i nga taonga, ka eke ki te rau kirokaramu
Tātai rāpoi	C27H23F2N3O7S
Taumaha rāpoi	571.55
Kiato	1.57±0.10 g/cm3
Wairewa	Wairewa i roto i te DMSO
Rokiroki mo te wa roa	Rokiroki mo te wa roa ki te -20 ℃
COA & MSDS	Kei te waatea
Taketake	Shanghai, Haina
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Ma ki te Paura-White
Tautuhinga	He rite te IR Spectrum ki te paerewa tohutoro Ko te wa pupuri e rite ana ki te paerewa tohutoro
Ihirangi Wai (na KF)	≤1.0%
Ngaronga i te whakamaroke	≤1.0%
Te toenga i runga i te mura	≤0.50%
Nga Korewa Taamaha	≤20ppm
Nga Taonga Paanga
Mōrahi te poke takitahi	≤0.50%
Nga poke katoa	≤1.0%
Rahi Matūriki	D90 Haere 150um
Chiral Pure	≥99.0%
Maamaa	≥99.0%
Te whakamatautau	98.0%~102.0%
Wairewa toenga	Whakaritea ki nga Whakaritenga ICH
Te tuku	Tukunga Ma te Tio Tio
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	API, i roto i te maimoatanga o te rewharewha A me nga mate rewharewha B

Mōkī me te Rokiroki:

Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.

Painga:

FAQ:

1985606-14-1 - Taupānga:

Ko Baloxavir Marboxil (CAS: 1985606-14-1, BXM, S-033188, Xofluza) he rongoa pareketo i whakawhanakehia e Shionogi Co., he kamupene rongoa Hapani me Roche mo te maimoatanga o te rewharewha A me nga mate rewharewha B.I whakaaetia te tarukino i te tuatahi mo te whakamahi i Hapani i te Hui-tanguru 2018 ka whakaaetia e te FDA i te Oketopa 24, 2018 mo te maimoatanga o te rewharewha whakapeka kore uaua i roto i nga turoro 12 tau me te pakeke ake kua pa mai nga tohu mo te kore neke atu i te 48 haora Tapanga.Ko Baloxavir marboxil, he aukati cap-endonuclease, he momo mahi ahurei ina whakatauritea ki te karaehe raau taero aukati neuraminidase kua whakamahia hei rongoa i nga mate rewharewha.Ko Baloxavir Marboxil he rongoa rewharewha hou me nga tikanga mahi hou.Ko Baloxavir Marboxil te hua o te Baloxavir Acid (S-033447) e kaha ana te aukati i te endonuclease e whakawhirinaki ana ki te potae i roto i te waahanga PA polymerase o nga huaketo rewharewha A me B, e arai ana ki te aukati i te tuhi RNA me te tukurua.I tirotirohia ano a Baloxavir mo tona kaha ki te rongoa i te COVID-19 engari kaore he painga i kitea.

1985606-14-1 - Hangahanga Mahi:

Ko Baloxavir Marboxil he kaihoko rongoa rewharewha, ina koa, he aukati i te whanariki e aro ana ki te mahi endonuclease e whakawhirinaki ana ki te rewharewha, tetahi o nga mahi a te wheori polymerase complex.Ina koa, ka aukati i tetahi tikanga e kiia nei ko te kapo kapo, na te huaketo e tango mai i nga korero poto, kapi mai i nga tuhinga RNA pūtau kaihautu, ka whakamahia mo te whakahiato polymerase-catalyzed o ona mRNA viral e hiahiatia ana.Ka herea he waeine polymerase ki te kaihautu i mua i nga mRNA i o ratou potae 5', katahi ka whakakorikori te mahi endonuclease o te polymerase i tana wehenga "i muri i te 10-13 nucleotides".Na tenei, he rereke tana tikanga mai i nga aukati neuraminidase penei i a Oseltamivir me Zanamivir.

1985606-14-1 - Pharmacokinetics:

Ko Baloxavir Marboxil he aukati whiriwhiri o te endonuclease e whakawhirinaki ana ki te potae rewharewha e aukati ana i te mahi polymerase, na reira ko te rewharewha rewharewha te tukuruatanga mRNA 5, 3. Kua whakaatuhia e ia te mahi whakaora ki nga mate rewharewha A me B, tae atu ki nga riaka e aukati ana ki nga maataki pareketo o naianei 1. Tenei tarukino ka aukati i te whākōkī e hiahiatia ana mo te tukuruatanga viral, na reira ka tere te rongoa i te mate rewharewha 5, Tapanga me te whakaiti i nga tohu e pa ana ki te mate.Ko te horopeta kotahi o tenei kaihoko i kitea he pai ake i te placebo hei whakaora i nga tohu rewharewha me te pai ake i te oseltamivir me te rongoa placebo i roto i nga putanga virologic (kua tohuhia e te whakahekenga o te uta viral).

1985606-14-1 - Tohu:

He pai te Baroxavir mo nga turoro ≥ 12 tau te pakeke e pa ana ki te rewharewha tino uaua me o raatau tohu kaore e neke atu i te 48 haora.Me aro ki nga herenga o te rongoa: ka huri te rewharewha i roto i te waa, a tera ano etahi ahuatanga penei i te momo wheori me te momo iti.I te wa ka huri te parenga tarukino o te huaketo me te pathogenicity o te huaketo, ka ngoikore te kaha haumanu o nga raau taero antiviral.I te wa e whakatau ana mena ka tango i te basalovir dipivoxil, me whai whakaaro nga korero e waatea ana mo te maaramatanga o te riaka mate urutaa a-rohe ki te tarukino.

1985606-14-1 - Whakamahinga:

Ko te Baloxavir Marboxil he rongoa rewharewha, he patu patu huaketo, ka tangohia hei papa horopeta kotahi, ma te waha, e nga tangata 12 tau neke atu ranei, kua puta nga tohu o tenei mate mo te kore neke atu i te 48 haora. Ko te whai hua o te Ko te baloxavir marboxil i tukuna i muri i te 48 haora kaore ano kia whakamatauria.

1985606-14-1 - Whakataunga:

Ko te Baloxavir Marboxil kaua e whakahaere tahi me nga hua miraka, nga inu whakakaha o te konupūmā, ki te rewharewha, ki te antacids, ki nga taapiri waha ranei kei roto te konupūmā, te rino, te konupora, te selenium, te konumohe, te zinc ranei.

1985606-14-1 - Nga Painga Taha:

Ko nga paanga taha noa i muri i te whakahaeretanga o te horopeta kotahi o te baloxavir marboxil ko te matere, te bronchitis, te makariri, te mahunga, me te nausea.I korerotia nga kino kino i roto i te 21% o nga tangata i whiwhi baloxavir, 25% o te hunga e whiwhi placebo, me te 25% o Oseltamivir.

1985606-14-1 - Whakaritenga:

I korerotia e te patent Japanese JP6212678 te tikanga whakahiato o Baloxavir Marboxil.3, 4-difluorobenzoic acid i whakamahia hei rauemi mata hei tauhohe ki te DMF i raro i te mahi a te LDA kia whiwhi 2-formyl-3, 4-difluorobenzoic acid.Na ka hanga he thioacetal me te thiophenol, katahi ka whakahekehia, ka wehea ki te borane kia whiwhi 2-phenylthiomethyl -3, 4-difluorob, 8-difluorodibenzo [B, e] thiazepine -11(6H)-kotahi, ka mutu ko te kongakonga thiazepine matua 7, 8-difluoro-6,11-dihydrodibenzo [B, e] thiazepine -11-waipiro ka whiwhi i raro i te whakahekenga o te konutai borohydride.Ma te whakamahi i te 3-(benzyloxy)-4-oxo-4H-pyran-2-carboxylic acid ki te tauhohe me te tert-butyl formate i muri i te whakamaaramatanga kia whiwhi 3-(benzyloxy)-1-((tert-butoxycarbonyl) amino) -4-oxo -1, 4-dihydropyridine-2-methyl formate hydrate, katahi me te 2-(2, 2-dimethoxyethoxy) ethylamine ka uru ki te tauhohenga whakawhiti urethane, ka huri i raro i te mahi a te waikawa methanesulfonic ki te whiwhi 7-(benzyloxy)-3, 4,12,12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyridino [2,1-f][1,2,4] triazine -6, 8-dione hemihydrate, katahi ka ka whakapoapoa ki te (R) -tetrahydrofuran -2-formic acid, ka whakamaarama, ka whakatauhia, katahi ka tangohia te roopu awhina chiral ki te tiki i te matua chiral matua mowhiti (R) -7-(benzyloxy) -3,4,12, 12a-tetrahydro-1H-[1,4] oxazino [3,4-c] pyrido [2,1-f][1,4] Triazine-6, 8-dione.Kātahi ka whakamahia te rāpoi ngota matua matua ki te whakawhiti ki te n-hexanol i raro i te mahi a te Grignard reagent, katahi me te kongakonga thiazepine matua 7,8-difluoro-6, 11-dihydrodibenzo [B, e] thiazepine -11-waiwa u. , me te mutunga o te tuatahitanga me te condensation me te methyl chloroformate kia whiwhi ai i te hua whakamutunga Baloxavir Marboxil.