Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8 Purity ≥99.5% (HPLC) Sitagliptin Phosphate Monohydrate Intermediate
Whakaratohia nga Kaiwaenga e Pa ana ki te Sitagliptin Phosphate Monohydrate:
Sitagliptin API CAS 486460-32-6
Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Waikawa CAS 209995-38-0
Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Wakawa Butyric CAS 486460-00-8
Sitagliptin Triazole Hydrochloride CAS 762240-92-6
Sitagliptin Phosphate Monohydrate Takawaenga CAS 486460-21-3
Ingoa matū | Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Wakawa Butyric |
Nga kupu taurite | (R)-Sitagliptin N-Boc-Wakawa poke |
Tau CAS | 486460-00-8 |
Tau CAT | RF-PI1192 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C15H18F3NO4 |
Taumaha rāpoi | 333.31 |
Te Whakarewa | 136.0~138.0 ℃ |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura-White |
Te tautuhi na HPLC | Ko te Wā Pupuri o te Tauira he rite ki te Paerewa Tohutoro |
Ngaronga i te whakamaroke | ≤0.50% |
Te pungarehu whanariki | ≤0.50% |
Nga Korewa Taamaha | <20ppm |
Isomer | ≤0.50% |
Nga Taonga Paanga | |
Te poke A | ≤0.50% |
Tetahi atu poke kotahi | ≤0.50% |
Nga poke katoa | ≤0.50% |
Maamaa | ≥99.5% (HPLC) |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | Takawaenga o Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9) |
Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku.
Ko te Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (CAS: 486460-00-8) he takawaenga nui mo te whakarite o te sitagliptin.Ko te Sitagliptinphosphate te dipeptidase -IV (DPP-4) tuatahi i whakaaetia e te FDA i te tau 2006. Ka whakamahia mo te maimoatanga o te mate huka momo II.Ka kitea te hua hypoglycemic i te wa e whakamahia ana e koe anake, i te whakakotahitanga ranei me te metformin me te pioglitazone, a he haumaru ki te tango, he pai te manawanui, he iti nga tauhohenga kino.I te marama o Akuhata 2009, i whakaaetia te tarukino e te Kotahitanga o Europi hei rongoa rarangi tuatahi mo te maimoatanga o te mate huka momo 2.Whai muri i te tau 2011, kua whakaaetia e tetahi i muri i tetahi atu whenua te whakakotahitanga o te sitagliptin phosphate me te alpha glycosidase inhibitors, te insulin ranei.Ko te Sitagliptin Phosphate te tuatahi o te aukati dipeptidyl peptidase-IV kua whakaaetia e te FDA hei whakamahi mo te maimoatanga o te mate huka momo 2 i tawhiti, i raro i te ingoa hokohoko Januvia.