Bortezomib CAS 179324-69-7 Purity ≥99.0% (HPLC) API Factory Purity Teitei
Whakaratohia nga Kaiwawao e Pa ana ki te Bortezomib me te Maamaa
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Bortezomib CAS 179324-69-7
| Ingoa matū | Bortezomib |
| Nga kupu taurite | Velcade, MG-341, PS-341 |
| Tau CAS | 179324-69-7 |
| Tau CAT | RF-API65 |
| Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
| Tātai rāpoi | C19H25BN4O4 |
| Taumaha rāpoi | 384.24 |
| Iwi Whakarewa | 122.0~124.0℃ |
| Kiato | 1.214 |
| Taurangi Refactive | 1.564 |
| Wairewa | Wairewa ki Chloroform, DMSO, Ewaro me te Mewaro |
| Te pumau | Hygroscopic me te makuku tairongo |
| Tikanga Tukunga | Ka tukuna i raro i te pāmahana ambient |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Paura Ma, Paura-Ma ranei |
| Te Maama / Tikanga Tatauria | ≥99.0% (HPLC) |
| Ngaronga i te whakamaroke | ≤0.50% |
| Te toenga i runga i te mura | ≤0.20% |
| Te hurihanga whatu | -41.0° ~ -46.0° |
| Metal Taumaha | ≤20ppm |
| Kawakawa | 4.0~7.0 |
| Isomer | ≤0.50% |
| Te poke kotahi | ≤0.50% |
| Nga poke katoa | ≤1.0% |
| Wairewa toenga | |
| Mewaro | ≤0.30% |
| Dichloromethane | ≤0.05% |
| Hexane | ≤0.02% |
| Ethyl Acetate | ≤0.50% |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | API |
Mōkī: Pounamu, Peeke konumohe konumohe, Paera Kaata, 25kg / Paera, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua me te kaiwhakarato o Bortezomib (CAS: 179324-69-7) me te kounga teitei, API.
Ko te Bortezomib, i hokona i raro i te ingoa waitohu Velcade me etahi atu, he rongoa aukati mate pukupuku e whakamahia ana ki te rongoa i te myeloma maha me te lymphoma pūtau koroka.I whakaaetia a Bortezomib mo te whakamahi rongoa i te United States i te tau 2003 me te Kotahitanga o Europi i te tau 2004. Kei runga i te Rarangi o nga Rongoa Whaiaro a te Whakahaere Hauora o te Ao.Ko Bortezomib te aukati proteasome tuatahi i whakaaetia e te US FDA mo te myeloma maha, he mate pukupuku toto.He aukati whakahuri o te 26S proteasome-he matūriki multiprotein te ahua o te oko ka kitea i roto i te karihi me te cytosol o nga pūtau eukaryotic katoa.Ko te Bortezomib he aukati 26S proteasome whiriwhiri me te pakari, he pärönaki dipeptide waikawa boronic.Ko nga rangahau o te mate pukupuku pancreatic tangata e whakaatu ana i te Bortezomib ki te aukati i te PKR-rite endoplasmic reticulum (ER) kinase me te whakarei ake i te ahotea ER, ka puta ki te apoptosis.
