Candesartan Cilexetil CAS 145040-37-5 Purity >99.0% (HPLC) API Factory
Ruifu Chemical Supply Candesartan Cilexetil Intermediate With High Pure
Candesartan Cilexetil CAS 145040-37-5
Candesartan CAS 139481-59-7
1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2
Candesartan Cilexetil Intermediate Eethyl Ester C6 CAS 139481-41-7
Candesartan Cilexetil Intermediate CAS 139481-44-0
Trityl Candesartan Cilexetil CAS 170791-09-0
Ingoa matū | Candesartan Cilexetil |
Nga kupu taurite | TCV-116;1-(((((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H -benzo[d]imidazole-7-Carboxylate |
Tau CAS | 145040-37-5 |
Tau CAT | RF-PI1891 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C33H34N6O6 |
Taumaha rāpoi | 610.66 |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura Tioata-White |
Tautuhinga HPLC | Ko te wa pupuri o te tihi nui i roto i te chromatogram o te tauira e rite ana ki tera i te chromatogram i whiwhi me te paerewa |
Tautuhinga IR | IR infrared absorption spectrum he rite ki tera o te paerewa tohutoro Candesartan Cilexetil |
Te Maama me te Rongoa Tae | Ko te otinga i roto i te chloroform i te 5% he maamaa me te kore tae |
Te Maama / Tikanga Tatauria | >99.0% (HPLC) |
Iwi Whakarewa | 155.0~160.0℃ |
Ngaronga i te whakamaroke | <0.30% |
Te toenga i runga i te mura | <0.10% |
Nga Korewa Taamaha | <10ppm |
Arsenic (As) | <1ppm |
Te Tohatoha Rahi Matūriki | 90% <30 μm |
Nga poke pararopi | na HPLC |
Ethyl Candesartan | <0.15% |
Desethyl Candesartan | <0.15% |
N2-Ethyl Candesartan Cilexei | <0.15% |
Tetahi poke kore mohiotia | <0.15% |
Nga poke katoa | <0.60% |
Te whakamatautau ma te Potentiometry | 99.0~101.0% o C33H34N6O6, kua tatauhia i runga i te matū waikore |
Te poke parakore | |
Methano | <0.30% |
Ewaro | <0.50% |
Diethyl Etera | <0.50% |
Aceton | <0.50% |
Dichloromethan | <0.06% |
Dimethylformamide | <0.088% |
Whakamaoritanga Microbiological | |
Tatau Moroiti Aerobic Tapeke | <1000cfu/g |
Maaka me te rewena | <100cfu/g |
E.Coli | Kei te ngaro |
Haramona | Kei te ngaro |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | API;Te Kaipupuri Atete |
Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku
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Ko Candesartan Cilexetil (TCV-116) (CAS: 145040-37-5) he angiotensin II receptor antagonist me te IC50 o te 0.26 nM, e whakamahia ana i roto i te maimoatanga o te whakaheke toto.Ko te Candesartan he angiotensin-receptor blocker (ARB) ka taea te whakamahi takitahi me etahi atu raau taero ki te rongoa i te whakaheke toto.Ka whakahaerehia ma te waha hei prodrug, candesartan cilexetil, ka tere te huri ki tana metabolite kaha, candesartan, i te wa e whakauru ana i roto i te gastrointestinal tract.Ka whakahekehia e Candesartan te pehanga toto ma te whakaeke i te punaha renin-angiotensin-aldosterone (RAAS);ka whakataetae ki te angiotensin II mo te here ki te momo-1 angiotensin II receptor (AT1) subtype me te aukati i te pehanga toto e piki ake nga paanga o te angiotensin II.Kaore i te rite ki te aukati angiotensin-converting enzyme (ACE), karekau he painga kino o te maremare o te ARB.Ka taea te whakamahi Candesartan ki te rongoa i te takawhita, te takawhita systolic taratahi, te hypertrophy ventricular maui me te nephropathy mate huka.Ka taea ano te whakamahi hei kaihoko rereke mo te maimoatanga o te ngoikore o te ngakau, te ngoikoretanga o te systolic, te infarction myocardial me te mate pukupuku coronary.
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