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Carvedilol CAS 72956-09-03 Purity >99.0% (HPLC) Atahanga Whakaatu
  • Carvedilol CAS 72956-09-03 Purity >99.0% (HPLC)

Carvedilol CAS 72956-09-03 Purity >99.0% (HPLC)

Whakaahuatanga Poto:

Ingoa matū: Carvedilol

CAS: 72956-09-03

Maamaa: >99.0% (HPLC)

Te ahua: Paura Tioata Maama

Whakapā: Takuta Alvin Huang

Pūkoro/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Taipitopito Hua

Hua e Pa ana

Tohu Hua

Whakaahuatanga:

Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o Carvedilol (CAS: 72956-09-03) me te kounga teitei.Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hoko Carvedilol,Please contact: alvin@ruifuchem.com

Takawaenga e pa ana:

Takawaenga e pa ana ki Carvedilol

Ngā Āhuatanga matū:

Ingoa matū Carvedilol
Nga kupu taurite 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-Methoxyphenoxy)ethyl]amino]-2-Propanol;Artist;Cadilan;Carca;Cardivas;Carloc;Carvas;Carvedilol;Carvediol;Korek;DQ 2466;Dilatrend;Dimitone;Eucardic;Korvasan;Kredex;Querto;Talliton;BM-14190
Tūnga Taonga Kei roto i nga taonga, GMP Commercial
Tau CAS 72956-09-3
Tātai rāpoi C24H26N2O4
Taumaha rāpoi 406.48 g/mol
Iwi Whakarewa 115.0 ki te 119.0 ℃
Kiato 1.250±0.06 g/cm3
Wairewa i te wai Karekau ki te wai
Wairewa Wairewa ki Methanol.He iti te wairewa ki te Ewaro, Etere
Rokiroki Temp. Wahi Matao me te maroke (2~8℃)
COA & MSDS Kei te waatea
Waitohu Ruifu Chemical

Whakatakotoranga:

Nga taonga Nga Paerewa Tirotiro Hua
Te ahua Paura Tioata Ma Ka tutuki
Ngaronga i te whakamaroke ≤0.50% (105℃ mō te 3 hāora) 0.25%
Te toenga i runga i te mura ≤0.10% 0.07%
Nga Taonga Paanga    
Nga poke katoa ≤0.50% Ka tutuki
Te poke A ≤0.20% Ka tutuki
Te poke C ≤0.02% Ka tutuki
Tetahi atu poke takitahi ≤0.10% Ka tutuki
Konga Taamaha (Pb) ≤10ppm <10ppm
Te Maama / Tikanga Tatauria >99.0% (HPLC) 99.72%
Spectrum Infrared He rite ki te Hanganga Ka tutuki
Whakamutunga Kua whakamatauria te hua me te whai ki nga whakaritenga

Mōkī/Rokiroki/Te tuku:

Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Rokiroki i roto i te ipu kati kati.Rokiroki i roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.

Painga:

Rawa Rawa: Rawa rawa nga whakaurunga me nga tohunga hangarau

Ratonga Ngaio: Kotahi te ratonga hoko mutu

Mōkī OEM: Moeke ritenga me te tapanga e waatea ana

Tukunga Tere: Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku

Whakapumau: Kia mau tonu nga taonga e tika ana

Tautoko Hangarau: Kei te waatea te otinga hangarau

Ratonga Hangarau Ritenga: Mai i te karamu ki te kirokaramu

Kounga Teitei: Kua whakaritea he punaha whakapumautanga kounga

FAQ:

Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.

Nga maakete matua?Hokona ki te maakete kaainga, Amerika Te Tai Tokerau, Uropi, Inia, Korea, Hapani, Ahitereiria, aha atu.

Nga painga?Ko te kounga teitei, te utu utu, nga ratonga ngaio me te tautoko hangarau, te tuku tere.

KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.

Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.

MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.

Wā Tukunga? Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku.

Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.

Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.

Whakaritenga Whakaritenga?Ka taea te whakarato ratonga whakahiato ritenga kia pai ai to hiahia rangahau.

Nga tikanga utu?Ko te nama Proforma ka tukuna tuatahi i muri i te whakapumautanga o te ota, ka kohia o maatau korero peeke.Te utu ma te T/T (Telex Transfer), PayPal, Western Union, etc.

72956-09-3 - Mōhiohio Haumaru:

Waehere morearea N,Xn
Tauākī mōrearea 51/53-36/37/38-20/21/22
Tauākī Haumaru 61-36-26
RIDADR UN 3077 9/PG 3
WGK Tiamana 3
RTECS UA8670000
HazardClass HARI
Roopu Paeke III
Raraunga matū morearea 72956-09-3(Raraunga matū morearea)
Te paitini LD50-waha i te kuri: > 1gm/kg

72956-09-3 -Taupānga:

Ko te Carvedilol (CAS: 72956-09-03) he beta-aukati vasodilating e whai hua ana ki te maimoatanga o te whakaheke toto me te angina pectoris.I tua atu i te whakaheke toto toto, ka whakahekehia e te carvedilol te katoa o te aukati vascular me te kore te tachycardia reflex e puta mai ana me nga vasodilators.E ai ki te korero he pai te whakamanawanui me nga paanga whakaora i nga whatukuhu.

I whakarewahia tuatahi a Carvedilol i Belgium i te 1985. Ka taea e tenei hua te aukati i nga kaiwhakawhiwhi alpha me te beta, kaore he mahi tuuturu, i roto i nga kohinga teitei o te ahua me te antagonism konupūmā.He kaha te kaha o te aukati i nga kaiwhakawhiwhi beta, ka taea te whakawhanui i nga oko toto, te whakaheke i te parenga o te peripheral me te whakaheke i te pehanga toto, me te iti o te paanga ki te whakaputanga ngakau me te tere o te ngakau.Ka taea te whakamahi haumanu mo te takawhita tuatahi me te angina pectoris.

72956-09-3 - USP 35 Paerewa:

WHAKAMAHI
Kei te Carvedilol te NLT 98.0% me te NMT 102.0% o C24H26N2O4, kua tatauhia i runga i te whakamaroke.
WHAKATAUTANGA
• A. Te Kohanga Pokarekare <197K>
• B. Ko te wa pupuri o te tihi nui o te otinga Tauira e rite ana ki tera o te otinga Paerewa, i riro mai i roto i te Assay.
WHAKAMAHI
• Tikanga
Pūreirei: 2.72 g/L o te pāhare pāporo phosphate monobasic.Whakaritea me te waikawa phosphoric waimeha ki te pH 2.0.
Waahanga pūkoro: Acetonitrile me te Kaipupuri (31:69)

Te otinga pai o te punaha: 0.05 mg/mL ia USP Carvedilol RS me te USP Carvedilol Related Compound A RS i te wahanga Waea Pukoro
Te otinga paerewa: 0.04 mg/mL o te USP Carvedilol RS i te wahanga Waea
Tauira otinga: 0.04 mg/mL o Carvedilol i te wahanga Waea Waea
Pūnaha Chromatographic

(Tirohia te Chromatography <621>, Whakaritenga Pūnaha.)
Aratau: LC
Kaitirotiro: UV 240 nm
Tīwae: 4.6-mm × 15-cm;5-µm kiki L7
Te pāmahana tīwae: 55℃
Rere rere: 1 mL/min
Wā oma: 60 min
Rahi werohanga: 10 µL
Te pai o te punaha

Tauira: Te otinga pai o te punaha
Nga whakaritenga e tika ana

Whakatau: NLT 4.0 i waenga i te carvedilol me te carvedilol e pa ana ki te puhui A
Te take hiku: NMT 1.5 mo te tihi carvedilol
Te inenga paerewa: NMT 2%
Tātaritanga

Tauira: otinga Paerewa me te otinga Tauira
Tātaihia te ōrau o te carvedilol (C24H26N2O4) i te wahanga o te tauira i tangohia:
Hua = (rU/rS) × (CS/CU) × 100
rU= te whakautu teitei o te carvedilol mai i te otinga Tauira
rS= te whakautu teitei o te carvedilol mai i te otinga Paerewa
CS= te kukū o te carvedilol i te otinga Paerewa (mg/mL)
CU= te kukū o Carvedilol i te Tauira otinga (mg/mL)
Paearu whakaae: 98.0% -102.0% i runga i te whakamaroke
NGA POKE
• Te toenga i runga i te mura <281>: NMT 0.1% mai i te 1 g
• Nga Koura Nui, Tikanga II <231>: NMT 10 ppm
• Te Parapara, Tikanga 1: [Tuhipoka-I runga i nga parapara e noho ana, mahia nga Parapara Parako, Tikanga 1, Nga Parapara Kore ranei, Tikanga 2. Ko nga Parapara, Tikanga 2 e taunaki ana ina he mea poke te pūhui F e hono ana ki te carvedilol.]

Wāhanga Buffer me te Waea Waea: Whakaritea kia rite ki te whakahau i roto i te whakamatautau.
Te otinga pai o te punaha: 0.05 mg/mL ia USP Carvedilol RS me USP Carvedilol Related Compound C RS i te wahanga Waea
Wairewa paerewa: 1 µg/mL ia USP Carvedilol RS, USP Carvedilol Related Compound A RS, USP Carvedilol Related Compound B RS, USP Carvedilol Related Compound D RS, me USP Carvedilol Related Compound E RS, me te 0.2 µg/mL o USP Carvedilol Pūhui C RS e pā ana ki te wahanga Pūkoro
Tauira otinga: 1 mg/mL o Carvedilol i te wahanga Waea Waea
Pūnaha Chromatographic
(Tirohia te Chromatography <621>, Whakaritenga Pūnaha.)
Aratau: LC

Kaitirotiro: Te roangaru rua, UV 220 me te 240 nm.Whakamahia te 220 nm mo te ine i te carvedilol e pa ana ki te puhui E, me te whakamahi i te 240 nm mo te carvedilol me era atu puhui e pa ana.
Tīwae: 4.6-mm × 15-cm;5-µm kiki L7
Te pāmahana tīwae: 55℃
Rere rere: 1 mL/min
Rahi werohanga: 20 µL
Te pai o te punaha

Tauira: Te otinga pai o te punaha
Nga whakaritenga e tika ana

Whakatau: NLT 17 i waenga i te carvedilol me te carvedilol e pa ana ki te puhui C
Tātaritanga
Tauira: otinga Paerewa me te otinga Tauira
Tātaihia te ōrau o te pūhui whai carvedilol A, pūhui whai carvedilol B, pūhui whai carvedilol C, pūhui whai carvedilol D, pūhui carvedilol E pā ana ki te carvedilol, me etahi atu poke takitahi i te wahanga o Carvedilol i tangohia:
Hua = (rU/rS) × (CS/CU) × 100
rU = te whakautu teitei o te pūhui e hāngai ana, tetahi atu poke ranei mai i te otinga Tauira
rS = whakautu teitei o te pūhui whai pānga mai i te otinga Paerewa.Ki te tatau i te ōrau o tetahi atu poke takitahi whakamahia te whakautu tihi o carvedilol.
CS = te kukū o te pūhui e pā ana ki te otinga Paerewa (mg/mL).Hei tātai i te ōrau o ētahi atu poke mō te CS, whakamahia te kukū o te USP Carvedilol RS.
CU = te kukū o Carvedilol i te Tauira otinga (mg/mL)
Paearu whakaae: Tirohia te Ripanga 1.

Ripanga 1
Ingoa Wā Pupuri Whanaunga Paearu Whakaae, NMT (%)
Carvedilol pūhui e pā ana Ea 0.35 0.1
Carvedilol pūhui Ab 0.52 0.1
Carvedilol bisalkylpyrocatechol derivative (mehemea kei reira)c 0.70 0.15
Carvedilol 1.0 —
Carvedilol pūhui hono Cd 3.6 0.02
Carvedilol pūhui hono De 5.0 0.1
Carvedilol pūhui hono Bf 8.5 0.1
Tetahi atu poke takitahi - 0.10
Ko nga poke katoa - 0.5g
he 2-(2-Methoxyphenoxy)ethyl amine.
b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol.
c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) propan-2-ol).
d 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
e 4-(Oxiran-2-ylmethoxy)-9H-carbazole.
f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
g Kaua e aro ki nga poke iti iho i te 0.01%.
• Nga Parakore, Tikanga 2

Otinga A: Acetonitrile me te waikawa trifluoroacetic (100:0.1)
Rongoā B: Te waikawa Trifluoroacetic me te wai (0.1:100)
Diluent: Acetonitrile, waikawa trifluoroacetic, me te wai (22:0.1:78)
Wāhanga pūkoro: Tirohia te Ripanga 2
Ripanga 2
Te wa
(mene)		 Rongoā A
(%)		 Otinga B
(%)
0 22 78
20 22 78
33 38 62
45 38 62
55 55 45
65 55 45
68 22 78
80 22 78
Te otinga pai o te punaha: 1.0 mg/mL o USP Carvedilol System Suitability Mixture RS i te Diluent
Tauira otinga: 1 mg/mL o Carvedilol i te Diluent
Pūnaha Chromatographic
(Tirohia te Chromatography <621>, Whakaritenga Pūnaha.)
Aratau: LC
Kaitirotiro: UV 240 nm
Tīwae: 4.6-mm x 15-cm;5-µm kiki L68
Te pāmahana tīwae: 30℃
Rere rere: 1.4 mL/min
Rahi werohanga: 20 µL
Te pai o te punaha
Tauira: Te otinga pai o te punaha
Nga whakaritenga e tika ana
Whakatau: NLT 1.8 i waenga i te carvedilol me te carvedilol e pa ana ki te pūhui F
Tātaritanga
Tauira: Tauira otinga
Tātaihia te ōrau o ia poke i te wahanga o Carvedilol i tangohia:
Hua = (rU/rT) × 100
rU = whakautu teitei mo ia poke i roto i te otinga Tauira
rT = te tapeke o nga whakautu teitei katoa i roto i te otinga Tauira
Paearu whakaae: Tirohia te Ripanga 3.
Ripanga 3

Ingoa Whanaunga
Te pupuri
Te wa		 Whakaaetanga
Paearu,
NMT (%)
Carvedilol pūhui Aa 0.7 0.1
Carvedilol 1.0 —
Carvedilol pūhui Fb 1.2 0.1c
N-Isopropylcarvedilold 1.6 0.1
Carvedilol pūhui hono Ce 1.8 0.02
Carvedilol pūhui hono Bf 2.1 0.1
Biscarbazoleg 3 0.1
Tetahi atu poke takitahi — 0.1
Ko nga poke katoa — 0.5
a 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2-ol .
b 1-(2-(2-Methoxyphenoxy)ethylamino)-3-(6,7,8,9-tetrahydro-5H-carbazol-4-yloxy)propan-2-ol.
c Ka inehia tenei poke ma te whakamahi i te tikanga i raro i nga Whakakorenga Organic, Tikanga 3: Carvedilol Related Compound F.
d 1-(H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]N-isopropylamino]-2-propanol.
e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
g 1,3-Bis-(9H-carbazol-4-yloxy)-2-propanol.
• Nga Parakore, Tikanga 3: Carvedilol Related Compound F (mehemea kei reira)

Rongoā A: Te waikawa Trifluoroacetic me te wai (0.5:100)
Rongoā B: Mewaro me te waikawa trifluoroacetic (100:0.5)
Wai me te acetonitrile (1:1)
Wāhanga pūkoro: Rongoā A me Rongoā B (65:35)
Te otinga pai o te punaha: 1.5 mg/mL o te USP Carvedilol System Suitability Mixture RS i te Diluent
Tauira otinga: 1.5 mg/mL o Carvedilol i roto i te Diluent kua rite e whai ake nei.Whakamahia te 1.9 mL o te Diluent mo ia mg o te Carvedilol, me te sonicate poto hei whakahaere i te whakakorenga.
Pūnaha Chromatographic

(Tirohia te Chromatography <621>, Whakaritenga Pūnaha.)
Aratau: LC
Kaitirotiro: UV 226 nm
Tīwae: 4.6-mm × 30-mm;3-µm tākai L7
Te pāmahana tīwae: 40℃
Rere rere: 2 mL/min
Rahi werohanga: 10 µL
Te pai o te punaha
Tauira: Te otinga pai o te punaha
Nga whakaritenga e tika ana
Whakatau: NLT 2.0 i waenga i te carvedilol me te carvedilol e pa ana ki te pūhui F
Tātaritanga
Tauira: Tauira otinga
Tātaihia te ōrau o te pūhui whai carvedilol F i te wahanga o te tauira i tangohia:
Hua = (rU/rT) × (1/F) × 100
rU = te whakautu teitei o te carvedilol pūhui F mai i te Tauira otinga
rT = te tapeke o nga whakautu teitei o te carvedilol me te carvedilol e pa ana ki te pūhui F mai i te Tauira otinga
F = tauwehe whakautu whanaunga, 1.1
Paearu whakaae: NMT 0.1%
NGA WHAKAMATAUTANGA
• Ngaronga i te whakamaroke <731>: Me whakamaroke he tauira ki te 105 ℃ mo te 3 haora: ka ngaro te NMT 0.5% o tona taumaha.
HE WHAKAMAHI ATU
• Te Whakapai me te Rokiroki: Whakaorangia ki roto i nga ipu kiki, ka penapena ki te pāmahana rūma e whakahaeretia ana.
• Te Tapanga: Mena ka whakamahia he whakamatautau mo nga Parakore a HPLC i tua atu i te Tikanga 1, ka tohuhia e te tapanga te whakamatautau e tutuki ai te tuhinga.
• Paerewa Tohutoro USP <11>

USP Carvedilol RS
USP Carvedilol Related Compound A RS
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2- ol.
C36H43N3O7 629.74
USP Carvedilol Related Compound B RS
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74
USP Carvedilol Related Compound C RS
1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
C31H32N2O4 496.60
USP Carvedilol Related Compound D RS
4-(Oxiran-2-ylmethoxy)-9H-carbazole.
C15H13NO2 239.27
USP Carvedilol Related Compound E RS
2-(2-Methoxyphenoxy)etil amine.
C9H13NO2 167.21
USP Carvedilol System Suitability Mixture RS
Te ranunga o te ahua 0.1% carvedilol pūhui e pā ana F (1-(2-(2-Methoxyphenoxy)ethylamino)-3-(2,3,4,9-tetrahydro-1H-carbazol-5-yloxy)propan-2-ol) i roto i te matrix o te matū tarukino carvedilol.
Tuhia to korero ki konei ka tukuna mai ki a matou