Risperidone CAS 106266-06-2 Assay 98.0~102.0%
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o Risperidone (CAS: 106266-06-2) me te kounga teitei.Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hoko Risperidone,Please contact: alvin@ruifuchem.com
| Ingoa matū | Risperidone |
| Nga kupu taurite | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]etil]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a] pyrimidin-4-one;Risperdal;Risperidal;Risperdal Consta;Rispolept;Risperin;Rispolin;Sequinan;Risperdal M-Ripa |
| Tūnga Taonga | I roto i te Stock, Production Arumoni |
| Tau CAS | 106266-06-2 |
| Tātai rāpoi | C23H27FN4O2 |
| Taumaha rāpoi | 410.49 g/mol |
| Iwi Whakarewa | 170.0 ki te 174.0 ℃ |
| Kiato | 1.38±0.10 g/cm3 |
| Te akomanga morearea | 6.1;paihana |
| COA & MSDS | Kei te waatea |
| Taketake | Shanghai, Haina |
| Waitohu | Ruifu Chemical |
| Nga taonga | Whakatakotoranga | Hua |
| Te ahua | Ma ki te Paura-White | Ka tutuki |
| Tautuhi A | Te horonga Infrared | Ka tutuki |
| Tautuhinga B | Wā Pupuri: He rite ki te Matū Tohutoro | Ka tutuki |
| Ngaronga i te whakamaroke | <0.50% | 0.12% |
| Te toenga i runga i te mura | <0.10% | 0.07% |
| Nga Korewa Taamaha | <0.001% | <0.001% |
| Pūhui Pānga | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| 9-Hydroxyrisperidone | <0.20% | <0.20% |
| 5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Tetahi poke kore mohiotia | <0.10% | <0.10% |
| Nga poke katoa | <0.30% | <0.30% |
| Te whakamatautau | 98.0~102.0% (Kua Tatauhia i runga i te Turanga maroke) | 100.52% |
| Whakamutunga | Kua whakamatauria te hua me te whai ki te USP 35 Paerewa | |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Risperidone
C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a] pyrimidin-4-one [106266-06-2].
» Kei roto i te Risperidone kaua e iti iho i te 98.0 paiheneti, kaua hoki e neke ake i te 102.0 paiheneti o C23H27FN4O2, kua tatauhia i runga i te tikanga whakamaroke.
Te takai me te rokiroki- Tiakina i roto i nga ipu kua kati pai.Rokiroki ki te pāmahana rūma.
Paerewa Tohutoro USP <11>-
USP Risperidone RS
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one 410.48 CAS-106266-06-2
USP Risperidone Pūnaha Whakariterite Ranu RS
Kei roto risperidone me te 0.2% o ia o enei e whai ake nei:
Z-Oxime-3-[2-[4-[(Z)-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, 8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
[Tuhipoka-Kei roto i tenei ranunga he risperidone, Z-oxime, 9-hydroxyrisperidone, me te 6-methylrisperidone.]
Tautuhinga-
A: Whakangao Infrared <197K>.
B: Ko te wa pupuri o te tihi nui i roto i te chromatogram o te whakaritenga Whakatau e rite ana ki tera i roto i te chromatogram o te whakaritenga Paerewa, i riro mai i te Assay.
Ngaronga i runga i te whakamaroke <731>- Me whakamaroke i roto i te korehau i te 80 mo te 4 haora: kaua e ngaro ake i te 0.5% o tona taumaha.
Te toenga i runga i te mura <281>: kaua e neke ake i te 0.1%, he tauira whakamatautau 2.0-g e whakamahia ana.
Nga konganuku taumaha, Tikanga II <231>: 0.001%.
Pūhui pā-
Wairewa Buffer, Solution A, Solution B, Waahanga Waea pūkoro, Diluent, Wairewa pai o te punaha, me te punaha Chromatographic-Whakaritea kia rite ki te whakahau i te Assay.
Wairewa Paerewa-Whakamahia te whakaritenga Paerewa, kua rite ki te tohutohu i roto i te Whakamaatau.
Whakamātautau otinga-Whakamahia te whakaritenga Assay.
Tikanga-Tukuhia nga pukapuka rite (e tata ana ki te 10 µL) o te otinga Paerewa me te otinga Whakamatau ki te chromatograph, ka tuhi i te chromatogram.Tautuhia nga poke ma te whakamahi i nga wa pupuri i te Ripanga 1, ka ine i nga whakautu teitei.Tātaihia te ōrau o ia pūhui e pā ana ki te risperidone i te wahanga o te Risperidone i tangohia e te tauira:
100(CS /CU)(rU / rS)(1/F)
kei roto ko CS me te CU nga kukū, i te mg ia mL, o te risperidone i roto i te otinga Paerewa me te otinga Whakamatau;Ko rU te waahi teitei o ia poke i puta mai i te otinga Whakamatau;Ko rS te waahi teitei o te risperidone i riro mai i te otinga Paerewa;me te F ko te tauwehe urupare mo ia poke e pa ana ki te risperidone.I tua atu i te kore e neke ake i nga tepe i te Ripanga 1, kaua e neke ake i te 0.10% o nga poke kore mohiotia (whakamahia te uara F o te 1.0) ka kitea, kaua e neke ake i te 0.30% o te katoa o nga poke ka kitea.Kaua e aro ki nga tihi poke he iti iho i te 0.05%.
Ripanga 1
Wā Pupuri Pātahi Pātahi (RRT) Tauwehe Whakautu Pānga (F) Tepe (%)
E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluorororisperidone4 0.94 1.0 NMT 0.20
Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4-[(E)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-one
2 3-[2-[4-[(Z)-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-one
3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one
5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
whakamātautau-
Wairewa Buffer- Whakarewahia te 15.4 g o te haukinia acetate ki te 1 rita o te wai.Whakaritea me te 10% waikawa ahetiki ki te pH 6.5, ka uru.
Otinga A-Whakaranuhia te 100 mL o te wairewa Buffer ki te 150 mL o te mewaro i roto i te ipu 1000-mL, ka waimeha ki te wai ki te rōrahi.
Otinga B- Whakaranuhia te 100 mL o te wairewa Buffer ki te 850 mL o te mewaro i roto i te ipu 1000-mL, ka whakahiatotia ki te wai ki te rōrahi.
Waahanga pūkoro-Whakamahia nga ranunga rereke o te Rongoa A me te Otinga B e kiia ana mo te punaha Chromatographic.Whakaritea nga whakarereketanga mehemea e tika ana (tirohia te Tikanga Pūnaha i raro i te Chromatography 621).
Diluent-Ranu 100 mL o te wairewa Buffer ki te 900 mL o te wai me te 1000 mL o te mewaro.
Te otinga pai o te punaha-Whakaritea he otinga 1 mg ia mL o te USP Risperidone System Suitability Mixture RS i roto i te Diluent.
Whakaritea Paerewa-Whakarewa i te rahinga tika o te USP Risperidone RS i roto i te Diluent, me te waimeha ine, me te hikoi mena e tika ana, me te Diluent kia whiwhi ai i tetahi otinga e mohiotia ana mo te 1.0 mg ia mL.
Whakaritea Whakamatau-Tarekahia te rahinga Risperidone i paunatia i roto i te Diluent, me te waimeha ine, me te hikoi mena e tika ana, me te Diluent ki te whiwhi otinga he 1.0 mg ia mL.
Pūnaha Chromatographic (tirohia te Chromatography <621>)- Ko te chromatograph wai he mea whakakakahu ki te 275-nm kaitahuri me te 4.6-mm × 10-cm tīwae kei roto 3-µm tarapi L1.Ko te tere rere he 1.5 mL ia meneti.Ka mau tonu te mahana o te pou ki te 35. Ko te chromatograph te whakatakotoranga penei.
Wā (mēneti) Rongoā A (%) Rongoā B (%) Elution
0–1 70 30 momotu
1–20 70®5 30®95 rōnaki rārangi
20–25 5 95 tito
25–27 5®70 95®30 rōnaki rārangi
27–35 70 30 whakaōrite anōTuhia te otinga pai o te Pūnaha.Tuhia nga whakautu teitei e kiia ana mo te Tikanga, me te tautuhi i nga tihi na te Z-oxime, 9-hydroxyrisperidone, 6-methylrisperidone, me te risperidone ma te whakamahi i nga wa pupuri whanaunga (RRT) mai i te Ripanga 1;ko te whakataunga, R, i waenga i te Z-oxime me te 9-hydroxyrisperidone kaua e iti iho i te 2.8;ko te take hiku mo te risperidone kaua e neke ake i te 1.5;me te inenga paerewa mo nga werohanga tukurua kaua e neke ake i te 2.0% mo te tihi risperidone.
Tikanga- Tuhia motuhaketia nga pukapuka rite (e tata ana ki te 10 µL) o te whakaritenga Paerewa me te whakareri Assay ki te chromatograph, ka ine i nga whakautu mo te tihi risperidone.Tātaihia te rahinga, i te ōrau o C23H27FN4O2, i te wāhanga o Risperidone i tangohia e te tātai:
100(CS /CU)(rU / rS)
kei roto ko te CS me te CU nga kohinga, i roto i te mg ia mL, o risperidone i roto i te whakaritenga Paerewa me te whakarite Whakatau, ia;me rU me rS nga whakautu teitei i puta mai i te whakaritenga Whakatau me te whakaritenga Paerewa.
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Waehere Morearea R25 - He paitini mena ka horomia
R23/24/25 - He paitini ma te horomia, ka pa ki te kiri me te horomia.
R11 - Tino muramura
Whakaahuatanga Haumaru S28 - I muri i te pa ki te kiri, horoi tonu me te maha o te hopi-hu.
S36 - Mau kakahu whakamarumaru tika.
S45 - Ki te aituā, ki te kore koe e pai, rapua he tohutohu hauora (whakaatuhia te tapanga ina taea.)
S36/37 - Mau kakahu whakamarumaru me nga karapu tika.
S16 - Mawehe atu i nga puna o te mura.
UN ID 3249
WGK Tiamana 3
RTECS UV1164800
Waehere HS 2934999099
Akomanga morearea 6.1(a)
Roopu Tapaki II
Risperidone (CAS: 106266-06-2) he antagonism antagonism ki nga kaiwhakawhiwhi 5HT2 me nga kaiwhakawhiwhi D2.Ka whakamahia te Risperidone mo te schizophrenia whakapeka me te mau tonu.Nga raau taero antipsychotic.Ka whakamahia te Risperidone mo te maimoatanga o te schizophrenia whakapeka me te mau tonu me etahi atu momo ahua hinengaro e kitea ana nga tohu pai (pēnei i te pohehe, te pohehe, te raruraru o te whakaaro, te mauahara, te whakapae) me nga tohu kino nui (pērā i te kore urupare, te kore aro nui me te kore aro ki te hapori, o te tokoiti. kupu).Ka taea hoki te whakaiti i nga tohu mate e pa ana ki te schizophrenia (pēnei i te: pouri, hara, awangawanga).Mo nga turoro e whai hua ana a Risperidone mo te maimoatanga whakapeka, i roto i te waahanga tiaki o te maimoatanga, ka taea e te Risperidone te mahi tonu i tona kaha haumanu.Ko te Risperidone, na reira, he mahi whakaora mo nga tohu pai me te kino o te schizophrenia me te iti rawa o nga paanga o te taha otira ko nga tohu extrapyramidal ka whakatauritea ki nga momo antipsychotics antagonist D2 parakore e whakamahia ana.Ka taea hoki e ia te whakahaere mo te tango i te waipiro me te taapiri cocaine.
