Vardenafil Intermediate CAS 224789-21-3 Purity>99.0% (HPLC)
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o 2-(2-Ethoxyphenyl) -5-Methyl-7-Propylimidazo [5,1-F][1,2,4] triazin-4(3H) -one (CAS: 224789-21-3) me te kounga teitei, te takawaenga o Vardenafil.Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona nga Kaiwaenga Vardenafil,Please contact: alvin@ruifuchem.com
| Ingoa matū | 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one |
| Nga kupu taurite | Vardenafil Dessulfonyl poke;2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazo [5,1-F][1,2,4] triazin-4-one;Vardenafil Propyl Imidazotriazinone poke;Vardenafil Pūhui Pātahi 1 |
| Tūnga Taonga | I roto i te Stock, Production Raukaha 2 Tons ia Marama |
| Tau CAS | 224789-21-3 |
| Tātai rāpoi | C17H20N4O2 |
| Taumaha rāpoi | 312.37 g/mol |
| Iwi Whakarewa | 142.0~148.0 ℃ |
| Kiato | 1.26±0.10 g/cm3 |
| Rokiroki mo te wa roa | Wahi Matao me te maroke (2~8℃) |
| COA & MSDS | Kei te waatea |
| Taketake | Shanghai, Haina |
| Waitohu | Ruifu Chemical |
| Nga taonga | Whakatakotoranga | Hua |
| Te ahua | Paura-White ki te Kowhai Kowhai Paura | Paura-Ma |
| Iwi Whakarewa | 142.0~148.0 ℃ | 146.0~147.0℃ |
| Ngaronga i te whakamaroke | <1.00% (102℃, 3h) | 0.23% |
| Konga Taamaha (Pb) | ≤20ppm | <20ppm |
| Te Maama / Tikanga Tatauria | >99.0% (HPLC) | 99.79% |
| 1H NMR Spectrum | E rite ana ki te Hanganga | Ka tutuki |
| Whakamutunga | Kua whakamatauria te hua me te whai ki nga whakaritenga kua tohua | |
| Taupānga | Takawaenga o Vardenafil / Vardenafil Hydrochloride | |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te ra me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
1. Te ahua: Tuhia te tauira ki runga pepa ma ka titiro ki te ahua, he ma-ma-ma ki te paura kowhai kowhai.
2. Tātaritanga:
2.1 Te whakatau i te Ira Whakarewa i runga i te ture (Hainamana Pharmacopoeia 2010 Edition II Apiti ⅥC) Ko te 142.0~148.0℃ te ira whakarewa.
2.2 Nga ngaronga mo te whakamaroke: Te whakatau i runga i te ture (Appendix ⅧL, Part II, 2010 Edition of Chinese Pharmacopoeia).He tika te pauna o tenei hua, maroke i te 102 ℃ mo te 3 haora, ko te mate taimaha kaua e neke ake i te 1.00%.
2.3 Nga Metara Teimaha: Te whakatau i runga i te ture (People's Republic of China Pharmacopoeia 2010 Edition, Part II Appendix ⅧH) Te whakatau ma te tikanga tuarua.
Ko te pauna tika 1.0karamu o te hua whakamatautau, ka ata tahuna kia tino warohia, whakamatao, taapirihia te 0.5-1.0ml waikawa pungatara, kia makuku, whakamahana i te pāmahana iti kia pau te waikawa pungatara, taapirihia te 0.5ml waikawa nitric, maroke mamaoa, tae noa ki te kua pau te hauota waikura kohu, matao, wera i te 500-600 ℃ kia tino warohia, whakamatao, tāpirihia te 2ml waikawa pūhaumāota, I muri i te whakamaroketanga i roto i te kaukau wai, tāpirihia te 15ml wai, maturuturu te otinga whakamātautau haukini kia noho kūpapa ki te tohu phenolphthalein wairewa, tāpirihia te 2ml acetate buffer (ph3.5), ka rewa paku wera, neke ki te ngongo tae Nachner, ka waimeha ki te 25ml ki te wai.Tangohia tetahi atu reagent mo te whakarite i te otinga whakamatautau, ka pupuhi ki roto i te rihi porcelain, tāpirihia te 2ml acetate buffer (PH3.5) me te 15ml wai ki te wera paku I muri i te whakakorenga, nekehia te Nath colorimetric ngongo, tāpirihia te nui o te otinga mata paerewa, ka waimeha ki te wai ki te 25ml.Ka mahia nga whakamatautau tae i waenga i te otinga whakamatautau me te otinga paerewa hei tiki.Whakaritenga otinga paerewa e ai ki te (People's Republic of China Pharmacopoeia 2010 putanga II Tāpiritanga Ⅷ Te tikanga whakamatautau whakarewa taumaha) te tikanga tuatahi.Ko nga konganuku taumaha kaua e neke ake i te 20 nga wahanga mo ia miriona.
3. Maamaa: E ai ki te chromatography wai mahi teitei, kua whakatauhia i runga i te ture (Hainamana Pharmacopoeia 2010 putanga II Appendix VD).
Tikanga Chromatographic:
Tīwae: C18, 200mm×4.6mm, 5μm;
Wāhanga pūkoro: Pūtaiao Phosphate (taiunahia te 2.72g pāhare pāporo dihydrogen phosphate, tāpirihia te wai ki te memeha me te waimeha ki te 1000ml, whakatika pH=3.5): acetonitrile: = 35:65;
Te roangaru rapu: 254nm;
Rere rere: 1.0ml/min.
Tikanga Whakatau: Tangohia te 30mg o tenei hua, pauna tika, waimeha ki te wahanga pūkoro kia 0.3mg/ml te kukū, tangohia te 20μl ki roto i te chromatograph wai, tuhia te chromatogram.E ai ki nga tikanga whakatikatika rohe, kaore i te iti iho i te 99.0% te ma.
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
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Ko te 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one (CAS: 224789-21-3) he takawaenga o Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).Ko Vardenafil he aukati PDE5 hou i whakarewahia mo te maimoatanga waha o te mate erectile tane me te mea he tino rite te hanganga ki te sildenafil (Viagra), ko te aukati PDE5 tuatahi i whakauruhia i te 1998 mo tenei tohu.
Ko Vardenafil te tuarua o nga kaihoko ki te hokohoko me te painga kaore i whakaitihia te wa o te timatanga ma te tango i te rongoa i runga i te kopu.Ko te 30 nga wa e kaha ake ana hei aukati i te PDE5 (te tikanga IC50, 3.9 nM) atu i te sildenafil me te 10 te kaha ake i te tadalafil, me te whiriwhiringa nui ake (> 1,000 wa) mo te tangata PDE5 atu mo te tangata PDE2, PDE3, me te PDE4 me ngawari te whiriwhiri (>80 wa) mo te PDE1.Ko te whiriwhiringa aukati PDE me te kaha o te in vitro me te in vivo o te aukati PDE5 hou vardenafil.I tino whakakorehia e Vardenafil te hydrolysis o cGMP na PDE5, me te IC50 o 0.7 nM (sildenafil 6.6 nM).Ko te IC50 o vardenafil mo PDE1 ko 180 nM, mo PDE6 11 nM, me te PDE2, PDE3 me PDE4 neke atu i te 1,000 nM.
