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Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)
Ko Ruifu Chemical te kaiwhakarato matua o Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) me te kounga teitei, te takawaenga o Apixaban (CAS: 503612-47-3).Ka taea e Ruifu te tuku i te ao, te utu whakataetae, te iti me te rahinga e waatea ana.Hokona nga takawaenga Apixaban, Ī-mēra: alvin@ruifuchem.com
| Ingoa matū | Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate |
| Nga kupu taurite | Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate;(Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene];Apixaban-2;Apixaban poke 3 |
| Tūnga Taonga | I roto i te Stock, Production Arumoni |
| Tau CAS | 27143-07-3 |
| Tātai rāpoi | C11H13ClN2O3 |
| Taumaha rāpoi | 256.69 g/mol |
| Iwi Whakarewa | 94℃ |
| Kiato | 1.23 |
| COA & MSDS | Kei te waatea |
| Taketake | Shanghai, Haina |
| Kāwai | Takawaenga o Apixaban (CAS: 503612-47-3) |
| Waitohu | Ruifu Chemical |
| Nga taonga | Nga Paerewa Tirotiro | Hua |
| Te ahua | Kowhai Maama ki te Paura Kowhai | Ka tutuki |
| Ngaronga i te whakamaroke | <0.50% | 0.23% |
| Te Maama / Tikanga Tatauria | ≥99.0% (HPLC) | 99.3% |
| Spectrum Infrared | He rite ki te Hanganga | Ka tutuki |
| 1 H NMR Spectrum | E rite ana ki te Hanganga | Ka tutuki |
| Whakamutunga | Kua whakamatauria te hua me te whai ki nga whakaritenga kua tohua | |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Rarangi o nga Wairewa e whakamahia ana ki te hanga
| Kao. | Ingoa | CAS No. | Tātai rāpoi |
| 1 | Ethyl Acetate | CAS: 141-78-6 | C4H8O2 |
| 2 | Dichloromethane | CAS: 75-09-2 | CH2Cl2 |
| 3 | Waipiro Ethyl | CAS: 64-17-5 | C2H5OH |
5.3.1 Te ahua: Me kowhai marama ki te paura kowhai.Ma te titiro, whakatakotohia te rahinga o te hua whakamatautau (kaore he pauna) ki roto i te rihi karaihe ma i runga i te papamuri ma (penei i te pepa ma) i raro i te maramatanga.
5.3.2 Tautuhinga: 1H-NMR he rite tonu te hanganga ki te paerewa.I paunatia te 10~15mg o te tauira ki roto i te ngongo autō karihi, ka tapirihia te 0.5mL o te deuterium DMSO kia tino memeha te tauira, katahi ka whakamatauria me te taputapu resonance autō karihi neke atu i te 400MHz.
5.3.3 Te ngaronga i te whakamaroke : Paunahia te tauira mo te 1.0g ka whakamaroke mo te 3 haora i roto i te oumu whakamaroke i te 85 ℃.Ko te mahi motuhake mo te tatauranga mate taimaha ka mahia kia rite ki nga tikanga o te SOP-AP-QC-002-01 mo te Whakataunga mo te Whakamotitia Ngaronga Taumaha.
5.3.4.1 Tikanga Chromatographic:
Nga tauhohenga whakamatautau: 1) acetonitrile mo te chromatography 2) te wai purea 3) te waikawa phosphoric
Tīwae: WondaCract ODS-2 4.6*250mm*5um (8520-39993)
Wāhanga pūkoro: A: Me ine tika te 1.0ml waikawa ūkuikui me te 1000ml wai, tātarihia te whakahekenga o te hau ultrasonic.
B: Acetonitrile.
Te tukanga rōnaki: te ripanga e whai ake nei
Wāhanga pūkoro A (%) Wāhanga pūkoro B (%)
3 90 10
10 25 75
20 0 100
25 0 100
Kaitirotiro: 210nm
Te pāmahana tīwae: 35℃
Te tere rere: 1.0ml / min
Rahi tauira: 5µl
5.3.4.2 Whakaritenga otinga:
5.3.4.3 Diluent: acetonitrile
5.3.4.4 Wairewa patea: me whakamahi te waimeha hei wairewa patea.
5.3.4.5 Te otinga hua whakamatautau: Paunatia te hua whakamatautau mo te 12.5mg i roto i te pounamu volumetric 25ml, ka rewa ki te waimeha ki te tauine.
5.3.4.6 Te tikanga whakahaere: I muri i te pumau o te turanga o te taputapu, kotahi ki te rua nga werohanga o te wairewa paatea, katahi ka tātarihia te otinga o te hua whakamatautau.Ka tiakina, ka tātarihia te chromatogram, ka tangohia te tihi tuwhera, a ko te tino maa me nga hua poke kotahi i runga i te chromatogram o te hua whakamatautau ka tuhia e te tikanga whakatikatika rohe.Whai muri i te tātari, ka taia te chromatogram.
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
Nga maakete matua?Hokona ki te maakete kaainga, Amerika Te Tai Tokerau, Uropi, Inia, Korea, Hapani, Ahitereiria, aha atu.
Nga painga?Ko te kounga teitei, te utu utu, nga ratonga ngaio me te tautoko hangarau, te tuku tere.
KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.
Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.
MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.
Wā Tukunga? Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku.
Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.
Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.
Whakaritenga Whakaritenga?Ka taea te whakarato ratonga whakahiato ritenga kia pai ai to hiahia rangahau.
Nga tikanga utu?Ko te nama Proforma ka tukuna tuatahi i muri i te whakapumautanga o te ota, ka kohia o maatau korero peeke.Te utu ma te T/T (Telex Transfer), PayPal, Western Union, etc.
Ko te Ethyl Chloro [(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) ka whakamahia hei takawaenga i roto i te whakahiato o Apixaban (CAS: 503612-47-3).Ko Apixaban he momo hou o te aukati take-waha Xa i hangaia e Bristol-Myers Squibb me Pfizer.Ko Erroto te ingoa hokohoko.He momo hou o te whakamau-a-waha.Na roto i te aukati i tetahi take nui o te coagulation Xa, ka taea e te apixaban te aukati i te hanga thrombin me te thrombosis.I whakawhanakehia a Apixaban e Bristal-Myers squibb Company.He pai te koiora me te whiriwhiringa teitei.I tuhia ki Haina i te tau 2013. He haumaru a Apixaban, he iti te waahi o te taunekeneke tarukino, a he maha nga huarahi hei whakakore, e tika ana kia whakamahia i roto i nga roopu motuhake e mate ana i te mate ate, i te kino o te mahi whatukuhu.
![Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_-300x300.jpg)
