CAS 361442-04-8 Purity >99.0% (HPLC) API

Whakaahuatanga Poto:

Nga kupu taurite: BMS-477118;Onglyza

CAS: 361442-04-8

Maamaa: >99.0% (HPLC)

Te ahua: Paura Ma

API, Kounga Teitei, Hanganga Aromoni

E-Mail: alvin@ruifuchem.com

Tukuna he imeera ki a matou

Taipitopito Hua

Hua e Pa ana

Tohu Hua

Whakaahuatanga:

Ruifu Chemical Supply Related Intermediates
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Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Wakawa Oxoacetic CAS 709031-28-7

Ngā Āhuatanga matū:

Nga kupu taurite	BMS-477118;Onglyza;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-Carbonitrile;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0]hexane -3-Carbonitrile
Tau CAS	361442-04-8
Tau CAT	RF-PI1991
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C18H25N3O2
Taumaha rāpoi	315.41
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Paura ma
Te kakara	Te ahuatanga
tautuhi	A: IR B: Waa Pupuri HPLC
Te Maama / Tikanga Tatauria	>99.0% (HPLC)
Maama o te Wairewa Wai	He Puata, Kore Tae, Kore Nga Take Itarewa
Tātari Tātari	100% Paahi 80 Mata
Iwi Whakarewa	202.0~212.0 ℃
Ngaronga i te whakamaroke	<0.50%
Te pungarehu whanariki	<0.20%
Hurihuri Tauwhāiti	+174.0°~+186.0°
Te poke kotahi	<0.50%
Nga poke katoa	<1.00%
Nga Korewa Taamaha	<10ppm
Arsenic (As)	<2.0ppm
Arataki (Pb)	<1.0ppm
Cadmium (Cd)	<1.0ppm
Wairewa toenga	<100ppm
Pesticide toenga	He kino
Microbiology
Tatau Pereti Tapeke	<1000cfu/g
Te rewena me te pokepokea ai	<100cfu/g
E. Coli	He kino
S. Aureus	He kino
Haramona	He kino
Te Ora Papa	24 Marama Mai i te Ra Hanganga mena ka penapena tika
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	API;Momo 2 mate huka toto

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

Painga:

FAQ:

Taupānga:

(BMS-477118) (CAS: 361442-04-8) he kaha, he whiriwhiri, he whakahuri, he whakataetae me te kaha o te waha o te dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM).Kei a BMS-477118 te peotential mo te rangahau mate huka momo 2.BMS-477118he momo mate huka momo 2 ka taea te whakaihiihi i te pancreas ki te whakaputa ake i te insulin i muri i te kai.I tae mai ma te mahi tahi a AstraZeneca me Bristol-Myers Squibb Company a no te DPP-IV inhibitor.BMS-477118ka whai waahi ma te aukati i te paheketanga o te GLP-l.Ko te GLP-I nga homoni i mahia i roto i te whekau i muri i te kai.Ka taea e ia te whakahaere i te whakaputanga o te insulin me te whakapakari i te whakamahinga o te huka i roto i nga kopa peripheral.Ka taea e te rongoa kotahi a BMS-477118 te whakapai ake i te mana o te huka toto me te whakakotahitanga o te rongoa o BMS-477118 me te Metformin, Sulfonylurea me Thiazolidinediones ka taea te whakarei ake i te hua whakaora.Ka iti ake te mate o te hypoglycemia me ona tauhohenga kino he rite ki te placebo, e whakaatu ana i te pai ake o te manawanui.I te Hūrae 31, 2009, BMS-477118 papa (Onglyza), he rongoa hou mo te mate huka momo 2, i rangahaua tahi me te whakawhanake i AstraZeneca me Bristol-Myers Squibb i whakaaetia e te US FDA.Ka taea te tango kotahi ia ra ki te rongoa i te mate huka momo 2 me te whakahaere i te kai me te korikori tinana.