5-(2-Pyridyl)-1,2-Dihydropyridin-2-one CAS 381233-78-9 Perampanel Intermediate Purity >98.0% (HPLC)
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o 5-(2-Pyridyl) -1,2-Dihydropyridin-2-one ([2,3'-Bipyridin] -6'(1'H) -one) (CAS: 381233-78-9) me te kounga teitei, te takawaenga o Perampanel (CAS: 380917-97-5).Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona nga takawaenga Perampanel,Please contact: alvin@ruifuchem.com
| Ingoa matū | 5-(2-Pyridyl)-1,2-Dihydropyridin-2-one |
| Nga kupu taurite | [2,3'-Bipyridin]-6'(1'H)-kotahi;5-(Pyridin-2-yl)pyridin-2(1H)-one;5-(Pyridin-2-yl)-2(1H)-Pyridone;5-(2-Pyridyl)pyridine-2(1H)-one;5-Pyridin-2-yl-1H-Pyridin-2-one;5-(Pyridin-2-yl)-1,2-Dihydropyridin-2-one;Parampanel poke 1 |
| Tūnga Taonga | I roto i te Stock, Production Arumoni |
| Tau CAS | 381233-78-9 |
| Tātai rāpoi | C10H8N2O |
| Taumaha rāpoi | 172.18 g/mol |
| Iwi Whakarewa | 71.0~75.0℃ |
| Kiato | 1.221±0.06 g/cm3 |
| COA & MSDS | Kei te waatea |
| Taketake | Shanghai, Haina |
| Kāwai | Takawaenga o Perampanel (CAS: 380917-97-5) |
| Te Ora Papa | 24 Marama ki te rongoa tika |
| Waitohu | Ruifu Chemical |
| Nga taonga | Nga Paerewa Tirotiro | Hua |
| Te ahua | Ma ki te paura tata ma | Paura ma |
| Te Maama / Tikanga Tatauria | >98.0% (HPLC) | 99.7% |
| Wai na Karl Fischer | <1.00% | 0.58% |
| Te poke kotahi | <1.00% | Ka tutuki |
| Nga poke katoa | <2.00% | 0.30% |
| 1H NMR Spectrum | E rite ana ki te Hanganga | Ka tutuki |
| Whakamutunga | Kua whakamatauria te hua me te whai ki nga whakaritenga kua tohua | |
| Taupānga | Takawaenga o Perampanel (CAS: 380917-97-5) | |
Mōkī:Pounamu Fluorinated, Peeke pepa konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati tonu te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
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Nga Ahuatanga: Paura ma ki te tata ma
Wairewa: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Ether, Petroleum Ether, n-Hexane, Dichloromethane
Tirotiro: Nga matū e pa ana: Tangohia tenei hua ka waimeha ki te waimeha (wai wahanga pūkoro: methanol (50∶50)) kia hanga he otinga kei roto tata ki te 0.5mg ia 1ml hei otinga hua whakamatautau.E ai ki te chromatography wai mahi teitei (Hainamana Pharmacopoeia 2010 Edition II Appendix Ⅴ D), i whakamahia te silica gel (ZORBAX SB-C18 4.6 × 250mm,5m) hei whakakii.Ko te wahanga pūkoro A he wai, ko te wahanga pūkoro B ko te methanol, ko te roangaru kitea he 254nm.Ko te tere rere ko 1.0ml/min me te pāmahana o te pou ko te pāmahana rūma.Ko te 5μl o te otinga whakamatautau i ine tika, ka werohia ki roto i te chromatograph wai hei tuhi i te chromatogram.E ai ki te tikanga whakatikatika rohe, ko te ihirangi o tenei hua kaore i te iti iho i te 98%.Mena he tihi poke i roto i te chromatogram o te otinga hua whakamatautau, ko te waahi pokenga takitahi e kore e neke atu i te 1.0%, me te nui o te waahi pokekore kaua e neke atu i te 2.0%.
Makuku: Tangohia tenei hua, whakamahia te whakamatautau makuku, kia rite ki te tikanga a Karl Fischer (Hainamana Pharmacopoeia 2010 putanga II Tāpiritanga Ⅷ M tikanga tuatahi A) te whakatau, kaua te makuku e nui ake i te 1.0%.
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
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Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.
Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.
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5-(2-Pyridyl)-1,2-Dihydropyridin-2-one ([2,3'-Bipyridin]-6'(1'H)-one) (CAS: 381233-78-9), he takawaenga o Perampanel (CAS: 380917-97-5).Ko Perampanel (he raihana i te tau 2012) he tuatoru-whakatupuranga AED e mohiotia ana me te ingoa tohu rangatira o Fycompa® (Eisai, Hatfield) i te UK me Banzel® (Eisai, Hatfield) i te USA.Te maimoatanga taapiri mo nga kaipahua arotahi me te whaanui tuarua ranei me nga rei tonic-clonic tuatahi.I te Oketopa 2012, i whakaaetia e te US FDA te perampanel mo te maimoatanga o te hopukanga o te wahanga i nga turoro epileptic he 12 tau te iti rawa.Ko Perampanel te tuatahi o nga kaiwhaiwhai AMPA ki te whiwhi whakaaetanga FDA hei AED.Ko nga kaiwhakawhiwhi glutamate AMPA ka kitea i runga i nga neuron postsynaptic i roto i te roro.Hei kaitoi whiriwhiri, kore whakataetae mo te AMPA, ka aukati te parampanel i te whakatuwheratanga o te hongere katote me te whakaiti i te whakawhänui o te kaha mahi.
