Lapatinib Ditosylate Monohydrate CAS 388082-78-8 Purity >99.0% (HPLC)
Ingoa matū | Lapatinib Ditosylate Monohydrate |
Nga kupu taurite | N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[5-[(2-methylsulfonylethylamino)methyl]furan-2-yl]quinazolin-4-amine |
Tau CAS | 388082-78-8 |
Tūnga Taonga | Kei roto i nga taonga |
Tātai rāpoi | C29H26ClFN4O4S·2(C7H8O3S)·H2O |
Taumaha rāpoi | 943.48 |
COA & MSDS | Kei te waatea |
Taketake | Shanghai, Haina |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Kowhai Kowhai ki te Paura Tioata Kowhai |
Te Maama / Tikanga Tatauria | ≥99.0% (HPLC) |
Iwi Whakarewa | 240.0~242.0℃ |
makuku (KF) | 1.9~2.4% |
Te poke kotahi | ≤0.50% |
Nga poke katoa | ≤1.00% |
Konga Taamaha (hei Pb) | ≤20ppm |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | API;Mo te maimoatanga o nga turoro me te mate pukupuku uma |
Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku
Ko te Lapatinib Ditosylate Monohydrate (CAS: 388082-78-8) te tote ditosylate oCAS 231277-92-2, he quinazoline waihanga, mahi-waha me te mahi antineoplastic pea.Ka whakakorea e ia te phosphorylation o te epidermal growth factor receptor (EGFR), ErbB2, me nga Erk-1 me-2 me AKT kinases;ka aukati hoki i nga taumata pūmua cyclin D i roto i nga raina pūtau puku tangata me nga xenografts.Ko te EGFR me te ErbB2 kua uru ki te tipu o nga momo pukupuku.I whakarewahia mo te maimoatanga o te HER2 (ErbB2) te mate pukupuku u pai i roto i nga wahine kua whiwhi maimoatanga o mua.I kitea te tarukino ka whakawhanakehia e GlaxoSmithKline.