Apixaban Intermediate CAS 503615-03-0 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-kotahi Purity ≥99.0% (HPLC)
Ko Ruifu Chemical te kaihanga matua o 3-Morpholino-1-(4-Nitrophenyl) -5,6-Dihydropyridin-2(1H)-one (CAS: 503615-03-0) me te kounga teitei.Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona nga takawaenga Apixaban,Please contact: alvin@ruifuchem.com
| Ingoa matū | 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-kotahi |
| Nga kupu taurite | 3-(4-Morpholinyl)-1-(4-Nitrophenyl)-5,6-Dihydro-2(1H)-Pyridinone;5,6-Dihydro-3-(4-Morpholinyl)-1-(4-Nitrophenyl)-2(1H)-Pyridinone;Apixaban Intermediate 3;Apixaban poke 36;Apixaban Tukatuka poke 1 |
| Tūnga Taonga | I roto i te Stock, Production Arumoni |
| Tau CAS | 503615-03-0 |
| Tātai rāpoi | C15H17N3O4 |
| Taumaha rāpoi | 303.31 g/mol |
| Iwi Whakarewa | 165.0~170.0℃ |
| Kohuatanga | 506.5±50.0℃ |
| Kiato | 1.357g/mL |
| COA & MSDS | Kei te waatea |
| Taketake | Shanghai, Haina |
| Kāwai | Takawaenga o Apixaban (CAS: 503612-47-3) |
| Waitohu | Ruifu Chemical |
| Nga taonga | Nga Paerewa Tirotiro | Hua |
| Te ahua | Paura Kōwhai | Paura Kōwhai |
| Iwi Whakarewa | 165.0~170.0℃ | 167.0~170.0 ℃ |
| Ngaronga i te whakamaroke | ≤0.50% | 0.3% |
| poke takitahi (Max.) | ≤0.50% | 0.3% |
| Nga poke katoa | ≤1.00% | 0.6% |
| Te Maama / Tikanga Tatauria | ≥99.0% (HPLC) | 99.4% |
| 1 H NMR Spectrum | E rite ana ki te Hanganga | Ka tutuki |
| LC/MS | E rite ana ki te Hanganga | Ka tutuki |
| Whakamutunga | Kua whakamatauria te hua me te whai ki nga whakaritenga kua tohua | |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
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Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
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Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.
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3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-kotahi (CAS: 503615-03-0) ko te takawaenga mo te whakahiato o Apixaban (CAS: 503612-47-3) .
Ko Apixaban he momo hou o te aukati take Xa-waha i hangaia e Bristol-Myers Squibb me Pfizer.Ko te ingoa hokohoko ko Eratol, he momo hou o te rongoa o-waha.Na roto i te aukati i tetahi take nui o te coagulation Xa, ka taea e Apixaban te aukati i te hanga thrombin me te thrombosis.
I te Paenga-whāwhā 26, 2007, i hono atu a Bristol-Myers Squibb ki a Pfizer ki te whakapuaki i te mahi tahi ki te whakawhanaketanga o te Apixaban anticoagulant waha hou na Bristol-Myers Squibb hei whakakapi mo te warfarin.E ai ki te whakaaetanga mahi tahi, ka utua e Pfizer he utu mo te US $0.25 piriona ki a Bristol-Myers Squibb ki te kawe i te 60% o te katoa o te utu whanaketanga o te anticoagulant Apixaban (ka whakatinanahia mai i te Hanuere 1, 2007), ko Bristol-Myers. Ka mau a Squibb i te toenga o te 40%, na reira ka whai mana ki te hanga tahi me te hoko i te tarukino.
I te marama o Haratua 2011, ko Apixaban te tuatahi ki te whakaae ki te aukati i te thrombosis venous i roto i nga turoro pakeke e mahi ana i nga mahi whakakapi hipoki, turi ranei i roto i nga whenua 27 EU, Iceland me Norway.
I te Whiringa-a-rangi 20, 2012, i whakaaetia e te Komihana a te Pakeha a Ererto (Apixaban) mo te aukati i te whiu me te embolism pūnaha i roto i nga turoro pakeke me te kore-valvular atrial fibrillation (NVAF) me te kotahi, neke atu ranei nga mea morearea.I muri mai, ka whakaaetia e te Canadian Food and Drug Administration, Japan, me te US FDA a Ererto (Apixaban) mo te aukati i te whiu me te embolism pūnaha i roto i nga turoro pakeke me te kore-valvular atrial fibrillation (NVAF) me te kotahi, neke atu ranei nga mea morearea.
I te Paenga-whāwhā 12, 2013, ko te rongoa anticoagulant hou Eloto (ELIQUIS)(apixaban) i hangaia tahitia e Bristol-Myers Squibb me Pfizer i panuitia mana kia whakarārangihia ki Haina.Ko Ererto he mea hou mo te aukati Xa-waha mo te aukati i te thromboembolism venous (VTE) i roto i nga turoro pakeke e whai ana i te whakakapi hipoki, turi ranei.Ko tana rarangi ingoa he whiringa hou haumaru me te whai hua mo te haumanu anticoagulation i muri i te pokanga orthopedic, me te kawe korero pai ki nga turoro Hainamana e whai ana i te whakakapi i te hip/turi.Kua whakapumautia e nga rangahau haumanu ko te whakataurite ki te 40mg enoxaparin kotahi ia ra, 2 nga wa ia ra ko te whakahaere waha o Eratol (Apixaban) 2.5mg he pai ake mo te aukati i te thromboembolism venous i muri i te pokanga whakakapi o te huha, turi ranei, kaore e nui ake te tupono o te whakaheke toto.
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