Crizotinib Intermediate CAS 877399-00-3 Purity ≥98.0% (HPLC) ee ≥99.0%
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00 -3) me te kounga teitei, te takawaenga o Crizotinib (CAS: 877399-52-5).Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona Crizotinib Intermediate,Please contact: alvin@ruifuchem.com
| Ingoa matū | (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine |
| Nga kupu taurite | Crizotinib Intermediate;Crizotinib Bromide poke;5-Bromo-3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]-2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amine |
| Tūnga Taonga | I roto i te Stock, Production Arumoni |
| Tau CAS | 877399-00-3 |
| Tātai rāpoi | C13H10BrCl2FN2O |
| Taumaha rāpoi | 380.04 g/mol |
| Iwi Whakarewa | 108.0 ki te 113.0 ℃ |
| Kiato | 1.643 |
| COA & MSDS | Kei te waatea |
| Tauira | Kei te waatea |
| Taketake | Shanghai, Haina |
| Kāwai | Takawaenga o Crizotinib (CAS: 877399-52-5) |
| Waitohu | Ruifu Chemical |
| Nga taonga | Nga Paerewa Tirotiro | Hua |
| Te ahua | Kowhai Maama Ki te Kowhai Paura ki Crystal | Ka tutuki |
| Iwi Whakarewa | 108.0 ki te 113.0 ℃ | Ka tutuki |
| Pure (Haha HPLC) | ≥98.0% | 99.1% |
| Te Taikaha Enantiomeric (EE) | ≥99.0% | 99.5% |
| Spectrum Infrared | He rite ki te Hanganga | Ka tutuki |
| 1 H NMR Spectrum | He rite ki te Hanganga | Ka tutuki |
| Whakamutunga | Kua whakamatauria tenei hua me te whai ki nga whakaritenga | |
| Te Ora Papa | 2 Tau ki te rongoa tika | |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
Nga maakete matua?Hokona ki te maakete kaainga, Amerika Te Tai Tokerau, Uropi, Inia, Korea, Hapani, Ahitereiria, aha atu.
Nga painga?Ko te kounga teitei, te utu utu, nga ratonga ngaio me te tautoko hangarau, te tuku tere.
KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.
Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.
MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.
Wā Tukunga? Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku.
Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.
Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.
Whakaritenga Whakaritenga?Ka taea te whakarato ratonga whakahiato ritenga kia pai ai to hiahia rangahau.
Nga tikanga utu?Ko te nama Proforma ka tukuna tuatahi i muri i te whakapumautanga o te ota, ka kohia o maatau korero peeke.Te utu ma te T/T (Telex Transfer), PayPal, Western Union, etc.
(R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00-3) ka whakamahia hei takawaenga o Crizotinib (CAS: 877399-52-5).
Ko te Crizotinib he tino rongoa mo te mate pukupuku ka noho hei alk (anaplastic lymphoma kinase) me te ros1 (c-ros oncogene 1) aukati, i whakaaetia mo te maimoatanga o etahi mate pukupuku pukupuku iti-iti (NSCLC) i Amerika me etahi atu whenua, a he maha nga rangahau e whakamatautau ana i tona haumaru me te whaihua ki te lymphoma pūtau nui anaplastic, neuroblastoma, me etahi atu pukupuku totoka matatau i roto i nga pakeke me nga tamariki.
Ko te Crizotinib he rongoa rongoa mo te mate pukupuku pūkahukahu kore-iti i whakawhanakehia e Pfizer, USA, ko te secorri he rongoa o mua me te wa-waahi i roto i te mara o te rongoa mo te mate pukupuku pūkahukahu.I whakaaetia mo te hokohoko i Amerika i te marama o Akuhata 2011, ka tuhia ki roto i nga aratohu maimoatanga mate pukupuku pukupuku o te ao i te mutunga o te tau hei rongoa rarangi tuatahi mo nga turoro ALK-pai.I whakaae tahi me Crizotinib ko te tikanga tātari ira tuatahi ma te whakamahi i te fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, koinei te tikanga e whakamahia ana i tenei wa i roto i nga whakamatautau haumanu o te ao ki te kite i nga ira whakakotahitanga EML4-ALK i NSCLC.Ka awhina tenei whakamatautau ki te tautuhi i nga turoro ka whai hua mai i te maimoatanga Crizotinib.
Ko te Crizotinib he kaitao kaikawe tyrosine kinase e whakamahia ana i roto i te whakamaarama i nga keehi kua tohua mo te mate pukupuku o te puku kore-iti.Ko te ATP e rua te aukati whakataetae o te tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (pūtau IC50 = 8 nM) me te ALK (pūtau IC50 = 20 nM), he mea nui enei e rua mo te mate pukupuku mate pukupuku.I te wa i whakamatauria a Crizotinib mo te whiriwhiringa ki etahi atu kinase ka kitea he IC50 te enzyme i roto i te 100 whakareatanga o c-MET mo te 13 o nga kinases 120 i whakamatauria.I roto i nga whakamatautau waea, i kitea a Crizotinib ki te aukati i te RON (recepteur d'origine nantais) kinase me te matapihi whiriwhiringa 10-fold i runga i te c-MET.Katoa, ka aukati tenei kaihoko i te tipu o nga pūtau puku.Ko te XALKORI®(Crizotinib) he rongoa rongoa e whakamahia ana hei rongoa i nga tangata whai mate pukupuku pūkahukahu kore-iti (NSCLC) kua horapa ki etahi atu wahanga o te tinana, na te koha o te ira e kiia nei ko ALK (anaplastic lymphoma kinase) ranei he ira ko ROS1.Kaore i te mohiotia mena he haumaru me te whai hua a XALKORI ki nga tamariki.
