1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Purity ≥98.0% (HPLC)
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o 1-Boc-4-(4-Bromopyrazol-1-yl) piperidine (CAS: 877399-50-3) me te kounga teitei, te takawaenga o Crizotinib (CAS: 877399- 52-5).Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Ingoa matū | 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine |
| Nga kupu taurite | Crizotinib-D;tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylic Acid tert-Butyl Ester;1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino)-4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;tert-butyl 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;1-(4-Boc-1-Piperidinyl)-4-Bromopyrazole;Crizotinib poke 4 |
| Tūnga Taonga | I roto i te Stock, Production Arumoni |
| Tau CAS | 877399-50-3 |
| Tātai rāpoi | C13H20BrN3O2 |
| Taumaha rāpoi | 330.23 g/mol |
| Iwi Whakarewa | 77.0 ki te 81.0 ℃ |
| Kiato | 1.43 |
| Wairewa | Wairewa ki Methanol |
| COA & MSDS | Kei te waatea |
| Taketake | Shanghai, Haina |
| Kāwai | Takawaenga o Crizotinib (CAS: 877399-52-5) |
| Waitohu | Ruifu Chemical |
| Nga taonga | Nga Paerewa Tirotiro | Hua |
| Te ahua | Mā Mārō | Mā Mārō |
| Iwi Whakarewa | 77.0 ki te 81.0 ℃ | Ka tutuki |
| Wai na Karl Fischer | <0.50% | 0.11% |
| Te Maama / Tikanga Tatauria | ≥98.0% (HPLC) | 99.3% |
| 1H NMR Spectrum | He rite ki te Hanganga | Ka tutuki |
| Mass | He rite ki te Hanganga | Ka tutuki |
| Whakamutunga | Kua whakamatauria te hua me te whai ki nga whakaritenga kua tohua | |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
Nga maakete matua?Hokona ki te maakete kaainga, Amerika Te Tai Tokerau, Uropi, Inia, Korea, Hapani, Ahitereiria, aha atu.
Nga painga?Ko te kounga teitei, te utu utu, nga ratonga ngaio me te tautoko hangarau, te tuku tere.
KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.
Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.
MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.
Wā Tukunga? Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku.
Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.
Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.
Whakaritenga Whakaritenga?Ka taea te whakarato ratonga whakahiato ritenga kia pai ai to hiahia rangahau.
Nga tikanga utu?Ko te nama Proforma ka tukuna tuatahi i muri i te whakapumautanga o te ota, ka kohia o maatau korero peeke.Te utu ma te T/T (Telex Transfer), PayPal, Western Union, etc.
Nga Tohu Whakamate Xn - He kino
Waehere Morearea 22 - He kino ki te horomia
Ko te 1-Boc-4-(4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) ka whakamahia hei takawaenga o Crizotinib (CAS: 877399-52-5).Ko te Crizotinib (ingoa hokohoko Xalkori,) he rongoa mate pukupuku e mahi ana hei ALK (anaplastic lymphoma kinase) me te ROS1 (c-ros oncogene 1) aukati, i whakaaetia mo te maimoatanga o etahi mate pukupuku pukupuku kore-iti (NSCLC) i te US me etahi atu whenua, me nga whakamatautau haumanu e whakamatautau ana i tona haumaru me te whaihua inanaplastic lymphoma pūtau nui, neuroblastoma, me etahi atu pukupuku totoka matatau i roto i nga pakeke me nga tamariki.
I te marama o Akuhata 2011, i whakaaetia e te United States FDA a Crizotinib (PF- 02341066) mo te maimoatanga o te anaplastic lymphoma kinase (ALK) kua whakarereketia te mate pukupuku pukupuku kore-iti-iti (NSCLC).Ko te Crizotinib he kaiwhakataetae whakataetae ATP takirua o te tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (pūtau IC50 = 8 nM) me te ALK (pūtau IC50 = 20 nM), he mea nui enei e rua mo te mate pukupuku mate pukupuku.I te wa i whakamatauria a Crizotinib mo te whiriwhiringa ki etahi atu kinase ka kitea he IC50 te enzyme i roto i te 100 whakareatanga o c-MET mo te 13 o nga kinases 120 i whakamatauria.I roto i nga whakamatautau waea, i kitea a Crizotinib ki te aukati i te RON (recepteur d'origine nantais) kinase me te matapihi whiriwhiringa 10-fold i runga i te c-MET.
