1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole CAS 877399-73-0 Pure ≥99.0% (HPLC)
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o 1-(1-Boc-4-Piperidinyl) -4-Iodopyrazole (CAS: 877399-73-0) me te kounga teitei, takawaenga o Crizotinib (CAS: 877399-52 -5).Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Ingoa matū | 1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole |
| Nga kupu taurite | 1-Boc-4-(4-Iodo-1H-Pyrazol-1-yl)piperidine;tert-Butyl 4-(4-Iodo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;tert-Butyl 4-(4-Iodopyrazolyl)piperidinecarboxylate;Crizotinib poke 16 |
| Tūnga Taonga | I roto i te Stock, Production Arumoni |
| Tau CAS | 877399-73-0 |
| Tātai rāpoi | C13H20IN3O2 |
| Taumaha rāpoi | 377.22 g/mol |
| Iwi Whakarewa | 97℃ |
| Kiato | 1.60±0.10 g/cm3 |
| Tairongo | Maamaa Maamaa |
| Rokiroki Temp. | 2~8 ℃, Tiaki Mai i te Marama |
| COA & MSDS | Kei te waatea |
| Taketake | Shanghai, Haina |
| Kāwai | Takawaenga o Crizotinib (CAS: 877399-52-5) |
| Waitohu | Ruifu Chemical |
| Nga taonga | Nga Paerewa Tirotiro | Hua |
| Te ahua | Mā ki te Kōwhai Kōwhai Māmā | Mā Mārō |
| Te Maama / Tikanga Tatauria | ≥99.0% (HPLC) | 99.58% |
| Spectrum Infrared | He rite ki te Hanganga | Ka tutuki |
| 1 H NMR Spectrum | He rite ki te Hanganga | Ka tutuki |
| ESI+ | Ka rite | Ka tutuki |
| Whakamutunga | Kua whakamatauria te hua me te whai ki nga whakaritenga kua tohua | |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
Nga maakete matua?Hokona ki te maakete kaainga, Amerika Te Tai Tokerau, Uropi, Inia, Korea, Hapani, Ahitereiria, aha atu.
Nga painga?Ko te kounga teitei, te utu utu, nga ratonga ngaio me te tautoko hangarau, te tuku tere.
KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.
Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.
MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.
Wā Tukunga? Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku.
Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.
Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.
Whakaritenga Whakaritenga?Ka taea te whakarato ratonga whakahiato ritenga kia pai ai to hiahia rangahau.
Nga tikanga utu?Ko te nama Proforma ka tukuna tuatahi i muri i te whakapumautanga o te ota, ka kohia o maatau korero peeke.Te utu ma te T/T (Telex Transfer), PayPal, Western Union, etc.
1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) me te kounga teitei, te takawaenga o Crizotinib (CAS: 877399-52-5).Ko te Crizotinib he rongoa rongoa mo te mate pukupuku pūkahukahu kore-iti i whakawhanakehia e Pfizer, USA, ko te secorri he rongoa o mua me te wa-waahi i roto i te mara o te rongoa mo te mate pukupuku pūkahukahu.I whakaaetia mo te hokohoko i Amerika i te marama o Akuhata 2011, ka tuhia ki roto i nga aratohu maimoatanga mate pukupuku pukupuku o te ao i te mutunga o te tau hei rongoa rarangi tuatahi mo nga turoro ALK-pai.I whakaae tahi me Crizotinib ko te tikanga tātari ira tuatahi ma te whakamahi i te fluorescence in situ hybridization (FISH) -VSIs ALK Break Apart FISH Probe Kit, koinei te tikanga e whakamahia ana i tenei wa i roto i nga whakamatautau haumanu o te ao ki te kite i nga ira whakakotahitanga EML4-ALK i NSCLC.Ka awhina tenei whakamatautau ki te tautuhi i nga turoro ka whai hua mai i te maimoatanga Crizotinib.i runga i te 25, koinei te raau taero tuatahi ka whakamahia ki te maimoatanga o nga turoro me te mate pukupuku o te mate pukupuku o te rohe, te metastatic ranei, ko te NSCLC he lymphoma kinase anaplastic (ALK) -he pai i whakatauhia e te SFDA-whakaaetia.
Ko te Crizotinib (PF-02341066) Ko te Crizotinib he kaha c-Met me te aukati ALK, ko nga uara IC50 i roto i te whakamatautau pūtau he 11 nM me te 24 nM, ia.He aukati kaha o ROS1 me te uara Ki iti iho i te 0.025 nM.Ka taea e Crizotinib te whakakorikori i te autophagy i roto i te tini o nga raina pūtau mate pukupuku pūkahukahu ma te aukati i te ara STAT3.
