CAS 945667-22-1 Purity >99.0% (HPLC) API

Whakaahuatanga Poto:

CAS: 945667-22-1

Maamaa: >99.0% (HPLC)

Te ahua: Paura Ma

API, Kounga Teitei, Hanganga Aromoni

E-Mail: alvin@ruifuchem.com

Tukuna he imeera ki a matou

Taipitopito Hua

Hua e Pa ana

Tohu Hua

Whakaahuatanga:

Ruifu Chemical Supply Related Intermediates
CAS 361442-04-8
CAS 945667-22-1
(R)-1-Boc-3-Aminopiperidine CAS 188111-79-7
(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Wakawa Oxoacetic CAS 709031-28-7

Ngā Āhuatanga matū:

Nga kupu taurite	BMS-477118 Hydrate;Onglyza Hydrate;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ]hexane-3-Carbonitrile Hydrate
Tau CAS	945667-22-1
Tau CAT	RF-PI1992
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C18H25N3O2·H2O
Taumaha rāpoi	333.43
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Paura ma
tautuhi	A: IR B: Waa Pupuri HPLC
Te Maama / Tikanga Tatauria	>99.0% (HPLC, i runga i te mea kua maroke)
Ihirangi wai (KF)	5.3%~7.3%
Te toenga i runga i te mura	<0.20%
Te poke kotahi	<0.50%
Nga poke katoa	<1.00%
Nga Korewa Taamaha	<10ppm
Arsenic (As)	<2ppm
Microbiology
Tatau Pereti Tapeke	<1000cfu/g
Te rewena me te pokepokea ai	<100cfu/g
E. Coli	He kino
S. Aureus	He kino
Haramona	He kino
Te Ora Papa	24 Marama
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	API;Ka whakamahia mo te maimoatanga o te mate huka momo II

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

Painga:

FAQ:

Taupānga:

Ko te API (CAS: 945667-22-1) he kai-whakaaro dipeptidyl peptidase-4 (DPP4) ka taea te whakamahi hei whakawhanake maimoatanga mo te mate huka momo 2.Ko te kaitautoko DPP4 whiriwhiri me te whakahoki me te IC50 o 26 nM me te Ki o 1.3 nM.IC50 uara: 26 nM.Whainga: DPP4 in vitro: Kei a ia he Ki te aukati i te 1.3 nM mo te aukati DPP4, he 10-nui ake te kaha atu i te Sitagliptin (e rua ano nga aukati DPP4) me te Ki o 13 me te 18 nM.I tua atu, E whakaatu ana i te tino motuhake mo te DPP4 atu mo te DPP8 ranei DPP9 enzymes (400- me te 75-fold, ia).Ko te metablite hohe o taua mea he rua nga wa iti ake te kaha i to te matua.Ko nga mea e rua (CAS: 945667-22-1) me tana metabolite he tino whiriwhiri (> 4000-fold) mo te aukati i te DPP4 ka whakatauritea ki te whānuitanga o etahi atu proteases.(CAS: 945667-22-1) ka whakaiti i te paheketanga o te incretin hormone glucagon-like peptide-1, na reira ka whakarei ake i ana mahi, ka hono ki te pai ake o te mahi β-cell me te aukati i te hunanga o te glucagon.in vivo: He tino whai hua. i te whakaputa i nga whakanikonikotanga e whakawhirinaki ana ki te horopeta kua tohua i roto i te whakaeatanga hukahuka i roto i te awhe horopeta 0.13-1.3 mg/kg i roto i nga kiore ob/ob e pa ana ki nga mana whakahaere.