Celecoxib CAS 169590-42-5 Assay 98.0~102.0%
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua o Celecoxib (CAS: 169590-42-5) me te kounga teitei.Ka taea e Ruifu Chemical te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona Celecoxib,Please contact: alvin@ruifuchem.com
| Ingoa matū | Celecoxib |
| Nga kupu taurite | Celebrex;Celebra;Celecox;Onsenal;Solexa;SC-58635;SC 58635;YM-177;4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-yl]benzenesulfonamide;5-(4-Methylphenyl)-1-(4-Sulfamoylphenyl)-3-(Trifluoromethyl)pyrazole |
| Tūnga Taonga | I roto i te Stock, Production Arumoni |
| Tau CAS | 169590-42-5 |
| Tātai rāpoi | C17H14F3N3O2S |
| Taumaha rāpoi | 381.37 g/mol |
| Iwi Whakarewa | 160.0 ki te 165.0 ℃ |
| Kiato | 1.43±0.10 g/cm3 |
| Wairewa wai | Karekau ki te wai |
| Wairewa | Tino Wairewa i te Methanol;Wairewa ki te Ethanol |
| COA & MSDS | Kei te waatea |
| Tauira | Kei te waatea |
| Taketake | Shanghai, Haina |
| Waitohu | Ruifu Chemical |
| Nga taonga | Nga Paerewa Tirotiro | Hua |
| Te ahua | Paura ma, tata ma ranei te kirikiriata | Ka tutuki |
| Te whakamatautau | 98.0~102.0% | 99.8% |
| Iwi Whakarewa | 160.0 ki te 165.0 ℃ | 162.2℃ |
| Wai na Karl Fischer | <0.50% | 0.11% |
| Te toenga i runga i te mura | <0.20% | 0.05% |
| Konga Taamaha (Pb) | ≤20ppm | <10ppm |
| Celecoxib Pānga Pūhui A | <0.40% | <0.20% |
| Celecoxib Pūhui Pānga B | <0.10% | <0.10% |
| Takitahi poke kore tauwhāiti | <0.10% | <0.10% |
| Ko nga poke katoa | <0.50% | 0.20% |
| Spectrum Infrared | E rite ana ki te Hanganga | Ka tutuki |
| 1H NMR Spectrum | E rite ana ki te Hanganga | Ka tutuki |
| Whakamutunga | Kua whakamatauria te hua me te whai ki nga whakaritenga kua tohua | |
Mōkī:Pounamu Fluorinated, Peeke pepa konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Kia kati te ipu ka penapena ki roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Celecoxib
C17H14F3N3O2S 381.4
4-[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide [169590-42-5]
WHAKAMAHI
Kei a Celecoxib te NLT 98.0% me te NMT 102.0% o C17H14F3N3O2S, kua tatauhia i runga i te waikore.
WHAKATAUTANGA
• A. KAUPAPA INFRARED <197>: [Ka taea te whakamahi i nga Tikanga-Tuhipoka <197A>, <197K>, <197M> ranei i raro i te Absorption Infrared.]
[FAKATOKANGA-Mehemea he rerekee te ahua o te hiihini i whiwhi, whakamotitia te matū hei tirotirohia me te Paerewa Tohutoro motuhake ki te waipiro isopropyl, whakaeto ki te maroke, ka tuhi i te hiranga hou.]
• B. Ko te wa pupuri o te tihi nui o te otinga Tauira e rite ana ki tera o te otinga Paerewa, i riro mai i roto i te Assay.
WHAKAMAHI
• TE WHAKAMAHI
Pūreirei: 2.7 g/L o te pāhare pāporo phosphate monobasic kua whakatikahia me te waikawa ūkuikui ki te pH o 3.0 ± 0.2
Wāhanga pūkoro: Methanol, acetonitrile, me te Buffer (3:1:6)
Diluent: Mewaro me te wai (3:1)
Te otinga pai o te punaha: 0.5 mg/mL o te USP
Celecoxib RS me te 2.4 µg/mL ia USP Celecoxib Pūhui Pānga A RS me USP Celecoxib Pānga Puhui B RS i roto i te Diluent
Te otinga paerewa: 0.5 mg/mL o USP Celecoxib RS i roto i te Diluent
Tauira otinga: 0.5 mg/mL o Celecoxib i Diluent
Pūnaha Chromatographic
(Tirohia te Chromatography <621>, Whakaritenga Pūnaha.)
Aratau: LC
Kaitirotiro: UV 215 nm
Tīwae: 4.6-mm × 25-cm;5-µm tākai L11
Paemahana tīwae: 60°
Rere rere: 1.5 mL/min
Rahi werohanga: 25 µL
Te wa oma: Tata ki te 1.5 nga wa o te celecoxib peak elution
Te pai o te punaha
Tauira: Te otinga pai o te punaha me te otinga Paerewa
Nga whakaritenga e tika ana
Whakataunga: NLT 1.8 i waenga i te pūhui celecoxib A me te Celecoxib me te NLT 1.8 i waenga i te Celecoxib me te Celecoxib te pūhui B, te otinga pai o te punaha
Te inenga paerewa whaitake: NMT 0.73%, Wairewa Paerewa
Tātaritanga
Tauira: otinga Paerewa me te otinga Tauira
Tātaihia te ōrau o C17H14F3N3O2S i te wahanga o Celecoxib i tangohia:
Hua = (rU/rS) × (CS/CU) × 100
rU = te whakautu teitei mai i te Tauira otinga
rS = te whakautu teitei mai i te otinga Paerewa
CS = te kukū o te otinga Paerewa(mg/mL)
CU = te kukū o te otinga Tauira (mg/mL)
Paearu whakaae: 98.0% ~ 102.0% i runga i te kaupapa anhydrous
NGA POKE
Nga poke parakore
• NGĀ METAL TAHA: NMT 20 ppm
Diluent: Acetone me te wai (17:3)
Wairewa Paerewa: Whakarewahia te 1.0 mL o te Wairewa Arataki Paerewa, kua whakaritea i raro i nga Meanu taumaha <231>, Reagents Motuhake, me te Diluent ki te 20 mL.
Tauira otinga: Whakarewahia te 0.50 g Celecoxib ki te 20mL o te Diluent.
Wairewa patea: 20 mL o te Diluent
Tātaritanga
Tauira: Wairewa Paerewa, Wairewa Patea, me te otinga Tauira
Ki ia wairewa, tāpirihia te 2 mL o te pH 3.5 Acetate Buffer kua whakaritea i raro i nga Metal Taumaha <231>, Tikanga I. Whakaranuhia, ka tapirihia ki ia wairewa 1.2 mL o te turanga TS thioacetamide–glycerin.Whakaranuhia tonu, ka waiho kia tu mo te 2 min.Tukuna nga otinga ma te tātari 0.45-µm te rahi o te pore.Whakatauritehia nga waahi i runga i nga whiriwhiringa i riro mai i ia otinga.
Paearu whakaae: Ko te tae parauri-pango o te waahi ka puta mai i te otinga Tauira kaore i te kaha ake i te waahi ka puta mai i te otinga Paerewa.He muhu te whakamatautau ki te kore e whakaatuhia e te otinga Paerewa he tae parauri-pango ka whakaritea ki te otinga Patea.
• TOHUTOHU I RUNGA KAUPAPA <281>: NMT 0.2%, ma te whakamahi i te parapara konukawata.
Nga poke pararopi
• TE WHAKAMAHI
Puawai, Waa Waea Pukoro, Waimeha, Wairewa pai o te punaha, Tauira otinga, me te punaha Chromatographic: Haere ki te whakahau i roto i te Whakatau.
Wairewa Paerewa: 0.5 µg/mL o USP Celecoxib RS i te Diluent
Te pai o te punaha
Tauira: Te otinga pai o te punaha me te otinga Paerewa
Nga whakaritenga e tika ana
Whakataunga: NLT 1.8 i waenga i te pūhui A Celecoxib me Celecoxib me NLT 1.8 i waenga i te Celecoxib me te Celecoxib pūhui B, te otinga pai o te punaha
Tauwehenga tohu-ki-haruru: NLT 20, otinga Paerewa
Tātaritanga
Tauira: otinga Paerewa me te otinga Tauira
Tātaihia te ōrau o ia poke i te wahanga o Celecoxib i tangohia:
Hua = (rU/rS) × (CS/CU) × 100
rU = te whakautu teitei mo ia poke i te Tauira otinga
rS = te whakautu teitei o te celecoxib i te otinga Paerewa
CS = te kukū o te celecoxib i te otinga Paerewa (mg/mL)
CU = te kukū o Celecoxib i te Tauira otinga (mg/mL)
Paearu whakaae
Nga poke takitahi: Tirohia te Ripanga 1.
[FAKATOKANGA-Kaua e aro ki tetahi tihi poke iti iho i te 0.05%.]
Ripanga 1
| Ingoa | Wā Pupuri Whanaunga | Paearu Whakaae NMT (%) |
| Celecoxib related compound Aa | 0.9 | 0.4 |
| Celecoxib | 1.0 | — |
| Celecoxib pūhui Bb | 1.1 | 0.10 |
| Te poke takitahi kaore i tohua | — | 0.10 |
| Ko nga poke katoa | — | 0.5 |
he 4-[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
b 4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
NGA WHAKAMATAUTANGA
• WHAKATAUTANGA WAI, Tikanga I <921>: NMT 0.5%, ma te whakamahi i te tauira 400-mg
HE WHAKAMAHI ATU
• TE PAKITANGA ME TE WHAKAPUTANGA: Whakaorangia ki roto i nga ipu kiki, ka tiakina mai i te marama me te makuku.Rokiroki ki te pāmahana rūma
• USP REFERENCE STANDARD <11>
USP Celecoxib RS
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
C17H14F3N3O2S 381.4
USP Celecoxib Related Compound A RS
4-[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
C17H14F3N3O2S 381.4
USP Celecoxib Pūhui Pānga B RS
4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
C17H14F3N3O2S 381.4
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
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| Nga Tohu Whakamate | Xn - He kino |
| Waehere Morearea | R20/21/22 - He kino ma te horomia, ka pa ki te kiri me te horomia. |
| R52 - He kino ki nga rauropi wai | |
| R61 - Ka kino pea te tamaiti kare i whanau | |
| R60 - Ka kino pea te hua | |
| Whakaahuatanga Haumaru | S22 - Kaua e pupuhi puehu. |
| S24/25 - Kaua e pa ki te kiri me nga kanohi. | |
| S28 - I muri i te pa ki te kiri, horoi tonu me te maha o nga huu hopi. | |
| S37/39 - Kia mau nga karapu tika me te whakamarumaru kanohi/kanohi | |
| UN ID | UN 3077 9 / PGIII |
| WGK Tiamana | 3 |
| RTECS | DB2944937 |
| Waehere HS | 2935900090 |
| Te akomanga morearea | TANGATA |
Ko Celecoxib me Rofecoxib e rua nga aukati COX-2 e whakamahia ana i tenei wa.I angitu te whakawhanake e GD Searle & Pfizer Co. (US,) i tukuna i te tau 1999, ingoa hokohoko: Celebrex.Ko te Celecoxib he rongoa kore-steroidal, anti-inflammatory me te nui o te analgesic and anti-inflammatory effects, na te iti rawa o te mate o nga mate whewhe o runga me etahi atu raruraru.Ka whakamahia ki te haumanu ki te rongoa i te osteoarthritis whakapeka me te mau tonu me te rumati rūmātiki, me te mahi analgesic anti-inflammatory, hei whakaora i nga tohu me nga tohu o te osteoarthritis me te rheumatoid arthritis.
Celecoxib (CAS: 169590-42-5), Mo te awhina me te whakahaere i te osteoarthritis (OA), te rumati rūmātiki (RA), te rumati rumati taiohi (JRA), te spondylitis ankylosing, te mamae nui, te dysmenorrhea tuatahi me te taapiri waha ki te tiaki i nga turoro. me te polyposis adenomatous whanau.
Kei a Celecoxib (CAS: 169590-42-5) te mana whakaahuru me te analgesic o nga NSAID.Na tona hanganga matū, ka taea te whakakotahi ki te COX-2, ka taea te whakakore i te COX-2.Ko tana roopu phenyl e hono ana ki te hongere hydrophobic o COX-2, a ko tana sulfonamide hydrophilic ka hanga he mekameka hauwai me te 513 arginine me te 90 histidine i roto i te "pukoro taha" COX-2.Kei te piri tata hoki ki te arginine i te tuunga COX-2120 me te whai waahi ki te aukati i te COX-2 ki te huri i te waikawa arachidonic ki te prostaglandins e kino ana ki te tinana o te tangata. -2, Kaore e taea e Celecoxib te uru atu ki te ngota ngota COX-1, kaore ano hoki e aukati i tana huringa o te waikawa arachidonic ki roto i nga prostaglandins. Na, he pai nga hua anti-inflammatory me te analgesic, he tiaki i te mucosa pekiti, he tiaki i te rere toto renal, he whakarite i te whakahiato platelet, me te whakatau i te nga raruraru pukuriri o nga NSAID e whakamahia nuitia ana.
Ko te Celecoxib (CAS: 169590-42-5) e tohuhia ana mo te maimoatanga o te osteoarthritis me te mate rūmātiki.Ko tana whakamahinga he aukati i nga taangata e pa ana ki te sulfonamides me etahi atu NSAIDs.Me whakamahi ma te tupato ki nga tangata whai mate ate.Ka puta nga pahekoheko me etahi atu raau taero e whakapouri ana i te CYP2C9 (hei tauira, rifampin rifampin) ka whakataetae ranei mo te paopaotanga e tenei enzyme (hei tauira, fluconazole, leflunomide).Ko nga tauhohenga kino kino ki te celecoxib he ngawari ki te ngawari o nga paanga GI penei i te dyspepsia, te diarrhea, me te mamae o te puku.He iti noa nga paanga o te GI me nga whatukuhu.
