Chloramphenicol CAS 56-75-7 Purity ≥99.0% (HPLC) High Purity
Kaihanga Kaihanga me te Maamaa Teitei me te Whakangao Aromoni
(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 716-61-0
(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 2964-48-9
Chloramphenicol CAS 56-75-7
Ingoa matū | Chloramphenicol |
Nga kupu taurite | D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol;2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide |
Tau CAS | 56-75-7 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C11H12Cl2N2O5 |
Taumaha rāpoi | 323.13 |
Te Whakarewa | 149.0 ki te 153.0 ℃ (marama) |
Tairongo | Maamaa Maamaa |
Wairewa | Tino Wairewa i roto i te Ethanol, Methanol, Acetone.Wairewa ki te Etera, Chloroform.Kore ki te Benzene.Kare e memeha ki te wai |
Tikanga Tukunga | Ka tukuna i raro i te pāmahana ambient |
COA & MSDS | Kei te waatea |
Taketake | Shanghai, Haina |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura Kowhai Maama |
Tautuhi A | Te horonga Infrared |
Tautuhinga B | Ko te wa pupuri o te tihi nui i roto i te chromatogram o te whakarite Assay e rite ana ki tera i roto i te chromatogram o te whakaritenga Paerewa, i riro mai i te Assay. |
Hurihanga Optical Tauwhāiti | +17.0°~+20.0° |
Te Whakarewa | 149.0~153.0℃ |
Te kirikiriata | Ka tutuki nga whakaritenga |
pH | 4.5~7.5 |
Te poke kotahi | ≤0.50% |
Nga poke katoa | ≤1.00% |
Nga Korewa Taamaha | ≤20ppm |
Arsenic | ≤1ppm |
Ngaronga i te whakamaroke | ≤0.50% (105℃, 3 haora) |
Te toenga i runga i te mura | ≤0.10% |
Te Maama / Tikanga Tatauria | ≥99.0% (HPLC) |
Paerewa Whakamatau | Paerewa hinonga;JP;USP |
Mōkī: Pounamu, putea Aluminium, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama, i te makuku.
Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
Ko te Chloramphenicol kaua e iti iho i te 97.0 ōrau me te kore e neke ake i te 103.0 ōrau o C11H12Cl2N2O5.
Packaging me te rokiroki-Tiaki i roto i nga ipu kiki.
Tapanga-Kei te mea te tikanga mo te whakamahi i roto i te whakarite injectable horomata ranei te tahi atu puka inenga horomata, kī te tapanga e he horomata me i raro ki te tukatuka atu i roto i te faaineineraa o injectable atu horomata ranei puka inenga.
Paerewa Tohutoro USP <11>-
USP Chloramphenicol RS Pāwhiri ki te Tiro Hanganga
USP Endotoxin RS
Tautuhinga-
A: Whakangao Infrared <197K>.
B: Ko te wa pupuri o te tihi nui i roto i te chromatogram o te whakaritenga Whakatau e rite ana ki tera i roto i te chromatogram o te whakaritenga Paerewa, i riro mai i te Assay.
Awhe whakarewa <741>: i waenganui i te 149 me te 153.
Te hurihanga motuhake <781S>: i waenganui i +17.0 me +20.0.
Te otinga whakamatautau: 50 mg, kaore i whakamarokehia, mo ia mL, i roto i te waipiro maroke.
Crystallinity <695>: ka tutuki nga whakaritenga.
Endotoxins huakita 85-Kei te whakamahia te Chloramphenicol ki te whakarite i nga puka inenga injectable, kaua e neke ake i te 0.2 USP Endotoxin Unit mo ia mg o te chloramphenicol.
Te Maamaa 71- Ki te kii te tapanga he parakore te Chloramphenicol, ka tutuki i nga whakaritenga ina whakamatauria kia rite ki te whakahau mo te Membrane Filtration i raro i te Whakamatautanga mo te Maamaa o te Hua hei Tirotiro, engari ki te whakamahi i te 1 g tauira totoka.
pH <791>: i waenganui i te 4.5 me te 7.5, i roto i te whakatārewatanga wai kei roto 25 mg ia mL.
Chromatographic parakore-Whakarewahia te rahinga tika o te Chloramphenicol i roto i te methanol kia whiwhi ai i te otinga whakamatautau kei roto 10 mg ia mL.Whakaritea he otinga o te USP Chloramphenicol RS i roto i te methanol kei roto 10 mg ia mL (Waerewa Paerewa A).Ringihia nga wahanga o te wairewa Paerewa A ki te methanol kia whiwhi ai i te wairewa Paerewa B kei roto te 100 µg ia mL me te wairewa Paerewa C kei roto 50 µg ia mL.Hoatu etahi wahanga 20-µL motuhake o te otinga whakamatautau me nga otinga Paerewa B me C ki tetahi pereti chromatographic paparanga angiangi e tika ana (tirohia te Chromatography 621), kua pania ki te paparanga 0.25-mm o te ranunga chromatographic silica gel.Whakawhanakehia te chromatogram i roto i te punaha whakarewa he ranunga o te chloroform, methanol, me te waikawa acetic glacial (79:14:7) tae noa ki te neke o te mua whakarewa ki te toru hauwha o te roa o te pereti.Tangohia te pereti mai i te ruuma, whakamaroke-a-rangi, ka tirotirohia i raro i te rama UV ngaru-poto: ko tetahi waahi i tua atu i te waahi matua i puta mai i te otinga whakamatautau kaore e nui ake i te rahi me te kaha o te waahi matua i whiwhi mai i te otinga Paerewa B (1% ), me te tapeke o nga poke e tohuhia ana e nga waahi katoa i tua atu i te waahi matua, i runga i te whakataurite o te kaha o aua waahi me te kaha o nga waahi matua i riro mai i nga otinga Paerewa B me C, kaore e neke ake i te 2% .
whakamātautau-
Wāhanga pūkoro-Whakaritea he ranunga tātari tika o te wai, te mewaro, me te waikawa ahetiki huka (55:45:0.1).Whakaritea nga whakarereketanga mehemea e tika ana (tirohia te Tikanga Pūnaha i raro i te Chromatography 621).
Whakariterite Paerewa- Whakarewahia te rahinga tika o te USP Chloramphenicol RS i te wahanga Waea Waea, ka waimeha ine ine, me te hikoi mena e tika ana, me te Waa Waea Waea kia whiwhi otinga e mohiotia ana ko te 80 µg ia mL.Tātarihia tētahi wāhanga o tēnei otinga mā te tātari porosity 0.5-µm pai ake ranei, ka whakamahi i te filtrate maamaa hei whakarite Paerewa.
Te whakarite whakamatautau- Whakawhitihia te 200 mg o te Chloramphenicol, i tika te pauna, ki te 100-mL pounamu rōrahi, tāpirihia te wahanga Waea ki te rōrahi, ka uru.Whakawhitihia te 4.0 mL o te otinga ki te ipu 100-mL, waimeha ki te wahanga Waea pūkoro ki te rōrahi, ka uru.Tātarihia tētahi wāhanga o tēnei otinga mā te tātari porosity 0.5-µm pai ake ranei, ka whakamahi i te filtrate maamaa hei whakarite Whakatau.
Pūnaha Chromatographic (tirohia te Chromatography <621>)-Ko te chromatograph wai he mea taputapu ki te 280-nm pūtiro me te 4.6-mm × 10-cm tīwae kei roto 5-µm tarapēke L1.Ko te tere rere he 1 mL ia meneti.Chromatograph te Whakaritea Paerewa, ka tuhi i nga whakautu tihi e kiia ana i raro i te Tikanga: ko te pai o te pou e whakatauhia ana mai i te tihi tātari kaua e iti iho i te 1800 pereti ariā, te tauwehe hiku kaua e neke ake i te 2.0, me te inenga paerewa mo nga werohanga tukurua kaore i te. neke atu i te 1.0%.
Tikanga-[note-Whakamahia te tihi teitei e tohuhia ana nga whakautu tihi.] Me werohia nga pukapuka rite (tata ki te 10 µL) o te whakaritenga Paerewa me te whakaritenga Whakatau ki te chromatograph, tuhia nga chromatograms, me te ine i nga whakautu mo nga tihi nui.Tātaihia te rahinga, i te mg, o C11H12Cl2N2O5 i te wahanga o Chloramphenicol i tangohia e te tauira:
2.5C(rU / rS)
i roto i te C ko te kukū, i roto i te µg ia mL, o te USP Chloramphenicol RS i roto i te Whakarite Paerewa, a ko rU me rS ko nga whakautu teitei i puta mai i te Whakarite Whakatau me te Whakarite Paerewa, ia.
Chloramphenicol
C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide [56-75-7]
Ko te Chloramphenicol he iti iho i te 980 mg (te kaha) me te kore e neke ake i te 1020 mg (te kaha) mo ia mg, ka tatauhia i runga i te whakamaroke.Ko te kaha o te Chloramphenicol e whakaatuhia ana hei papatipu (kaha) o te chloramphenicol (C11H12Cl2N2O5).
Whakaahuatanga Ko te Chloramphenicol he ma ki te ma kowhai, he tioata, he paura tioata ranei.
He wairewa noa ki te mewaro me te waiwaro (99.5), me te wairewa paku ki te wai.
Tautuhinga (1) Whakatauhia te tuāwhiorangi whakauru o te tauira otinga i riro mai i roto i te Whakamatau pera i te whakahau i raro i te Ultraviolet-visible Spectrophotometry <2.24>, ka whakataurite i te tuāwhiorangi ki te Tohu Tohutoro, te hihinga ranei o te otinga o Chloramphenicol RS rite tonu te tauira otinga: e whakaatu ana nga hihinga e rua i te kaha o te whakaurunga i nga roangaru kotahi.
(2) Whakatauhia te tuāwhiorangi horomanga pōkākā o Chloramphenicol i runga i te tikanga kōpae pāhare pāporo bromide i raro i te Spectrophotometry Infrared <2.25>, ka whakatairitehia te tūāwhiorangi ki te Tūāwhiorangi Tohutoro, te tūāwhiorangi rānei o Chloramphenicol RS: e whakaatu ana ngā tūāwhiorangi e rua i te kaha o te whakaurunga i te rite tonu. tau ngaru.
Te hurihanga whatu <2.49> [a]20D: +18.5~+21.5℃ (1.25 g, te waihā (99.5), 25 mL, 100 mm).
Ira whakarewa <2.60> 150~155℃
Pure (1) Nga konganuku taumaha <1.07>-Haere ki te 1.0 g Chloramphenicol i runga i te Tikanga 2, ka mahia te whakamatautau.Whakapaia te otinga mana me te 2.5 mL o te Wairewa Aratohu Paerewa (kaua e neke ake i te 25 ppm).
(2) Arsenic <1.11>-Whakaritea te otinga whakamatautau me te 2.0 g o Chloramphenicol kia rite ki te Tikanga 4, ka mahi i te whakamatautau (kaua e neke ake i te 1 ppm).
(3) Nga matū e pa ana-Whakarewahia te 0.10 g Chloramphenicol ki te 10 mL o te mewaro, ka whakamahi i tenei otinga hei tauira otinga.Pipeto 1 mL o te tauira otinga, tāpirihia te mewaro kia rite ki te 100 mL, ka whakamahi i tenei otinga hei otinga paerewa (1).Pipeto 10 mL o te wairewa paerewa (1), tāpirihia te mewaro kia rite ki te 20 mL, ka whakamahi i tenei otinga hei otinga paerewa (2).Mahia te whakamatautau me enei rongoatanga pera i te whakahau i raro i te Thin-layer Chromatography <2.03>.Tuhia te 20 mL o ia tauira otinga me nga otinga paerewa (1) me te (2) ki runga i te pereti tiera silica me te tohu rewharewha mo te chromatography paparanga angiangi, whakawhanakehia te pereti me te ranunga o te chloroform, methanol me te waikawa acetic (100) ( 79:14:7) ki te tawhiti 15 cm, ka whakamaroke i te hau te pereti.Tirohia i raro i te rama ultraviolet (te roangaru matua: 254 nm): ko nga waahi i tua atu i te waahi matua me te waahi i runga i te taketake i puta mai i te tauira otinga kaore i te kaha ake i te waahi i puta mai i te otinga paerewa (1), me te tapeke tapeke. o enei waahi mai i te tauira otinga kaua e neke ake i te 2.0%.
Ngaronga i te whakamaroke <2.41> Kaua e neke ake i te 0.5% (1 g, 105℃, 3 haora).
Te toenga i runga i te mura <2.44> Kaua e neke ake i te 0.1%(1 g).
Whakamaatau Me paunatia te nui o te Chloramphenicol me te Chloramphenicol RS, e rite ana ki te 0.1 g (te kaha), memeha ia i roto i te 20 mL o te mewaro, me te taapiri i te wai kia rite ki te 100 mL.Pipeto 20 mL ia o enei wairewa, ka tapirihia he wai kia 100 mL.Pipeto 10 mL ia o enei wairewa, tapirihia he wai kia rite ki te 100 mL, ka whakamahi i enei rongoa hei tauira otinga me te otinga paerewa.Whakatauhia nga whakaurunga, AT me te AS, i te 278 nm o te tauira otinga me te otinga paerewa i raro i te Ultraviolet-visible Spectrophotometry <2.24>.
Te nui [mg (kaha)] o te chloramphenicol (C11H12Cl2N2O5)
= MS × AT/AS × 1000
MS: Te nui [mg (potency)] o Chloramphenicol RS
tangohia
Ipu me te rokiroki Ipu-Tight ipu.
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Waehere Morearea R45 - Ka mate pea te mate pukupuku
R11 - Tino muramura
R39/23/24/25 -
R23/24/25 - He paitini ma te horomia, ka pa ki te kiri me te horomia.
Whakaahuatanga Haumaru S53 - A ape i te rongo - whiwhi tohutohu motuhake i mua i te whakamahi.
S45 - Ki te aituā, ki te kore koe e pai, rapua he tohutohu hauora (whakaatuhia te tapanga ina taea.)
S16 - Mawehe atu i nga puna o te mura.
S36/37 - Mau kakahu whakamarumaru me nga karapu tika.
UN ID 2811
WGK Tiamana 3
RTECS AB6825000
FLUKA BRAND F CODES 3-10
TSCA Ae
Waehere HS 2941400000
Koehe morearea 3
Paitini LD50 waha i te kiore: 2500mg/kg
P501: Makahia nga mea kei roto/ ipu ki tetahi whare tuku para kua whakaaetia.
P260: Kaua e pupuhi i te puehu/ rehu/ hau/ kohu/ kohu/ rehu.
P270: Kaua e kai, inu, paowa ranei ina whakamahi i tenei hua.
P202: Kaua e hapai kia oti ra ano te panui me te mohio ki nga tikanga tiaki haumaru.
P201: Tikina nga tohutohu motuhake i mua i te whakamahi.
P264: Horoia te kiri i muri i te mahi.
P280: Ka mau i nga karapu whakamarumaru / kakahu whakamarumaru / tiaki kanohi / tiaki kanohi.
P308 + P313: Mēnā ka kitea, ka āwangawanga rānei: Tikina he tohutohu hauora.
P405: Kua tutakina te toa.
Ko Shanghai Ruifu Chemical Co., Ltd. te kaiwhakarato matua o Chloramphenicol (CAS: 56-75-7) me te kounga teitei.Ko te Chloramphenicol he paturopi antibacterial whanui whanui, koinei te whiringa tuatahi mo te maimoatanga o te taipoid me te paratyphoid, tuarua, ka whakamahia mo te maimoatanga o nga momo mate hopuhopu i puta mai i nga microorganisms tairongo.Na te nui o nga tauhohenga kino e whakamahia ana inaianei ka iti ake.Ko te hiranga antibacterial, te mahi me te whakamahi he rite tonu ki te chloramphenicol mo te maimoatanga o Salmonella Typhi, Shigella, Escherichia coli, rewharewha, Brucella, mate pneumonia na te cocci me etahi atu paturopi anti-infective drugs.Ko te Chloramphenicol te nuinga o te whakamahi ki te rongoa i te mate mimi, te Pneumonia, te mate puku me te septicemia na te huakita tairongo, tae atu ki nga pata kanohi o waho me nga pata taringa.
UN3249 Rongoa, totoka, paitini, nos, Piha Whakamate: 6.1;Tapanga: 6.1-Nga taonga paitini.UN2811 He totoka paihana, he waro, he nos, Koehe morearea: 6.1;Tapanga: 6.1- Nga taonga paitini, Ingoa Hangarau e hiahiatia ana.