Daptomycin CAS 103060-53-3 Purity ≥95.0% API Factory High Purity
Kaihanga me te Pure Nui me te Kounga Pumau
Ingoa matū: Daptomycin
CAS: 103060-53-3
API Kounga Teitei, Hanganga Tauhokohoko
Ingoa matū | Daptomycin |
Nga kupu taurite | LY146032 |
Tau CAS | 103060-53-3 |
Tau CAT | RF-API10 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C72H101N17O26 |
Taumaha rāpoi | 1620.69 |
Iwi Whakarewa | 202.0~204.0 ℃ |
Wairewa | Wairewa i te Methanol |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Te paura kowhai, kowhai ranei |
Tautuhinga HPLC | Ko te wa pupuri o te tihi nui o te tauira otinga kia rite ki tera o te paerewa tohutoro. |
Tautuhinga IR | Ko te tuāwhiorangi IR o te tauira whakamatautau kia rite ki te paerewa tohutoro tohutoro. |
Te ahua o te otinga | Maamaa Me maamaa te otinga, kaua ranei e nui ake te korero i tera o te whakatārewatanga tohutoro II. |
Hurihanga Optical Tauwhāiti | +17.0° ki te +25.0° |
pH | 4.0 ki te 5.0 |
Te toenga i runga i te mura | ≤1.0% |
Anhydro-Daptomycin | ≤2.5% |
β-Isomer | ≤0.50% |
Waiwai te poke | ≤0.50% |
poke 1 | ≤0.75% |
poke 2 | ≤0.75% |
poke 3 | ≤0.75% |
Tetahi atu poke | ≤0.15% |
Nga poke katoa | ≤5.0% |
Nga Korewa Taamaha | ≤30ppm |
Wai | ≤5.0% |
Maamaa | ≥95.0% (Kua tatauhia i runga i te whakamaroke) |
Endotoxins huakita | <0.3EU/mg |
Ngā Wehenga toenga n-Butanol | ≤5000ppm |
Wairewa Wairewa Isopropanol | ≤5000ppm |
Wairewa Wairewa Ewaro | ≤5000ppm |
Tepe Microbial TAMC | ≤100cfu/g |
Tepe Microbial TYMC | ≤10cfu/g |
E.Coil | Kaore i kitea |
Paerewa Whakamatau | Paerewa hinonga |
Nga Tikanga Rokiroki | Whakaorangia i roto i nga ipu kiki, ka rongoa ki te -25~-10 ℃. |
Whakamahinga | Mahinga Rongoa Hohe (API) |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko te Daptomycin (CAS: 103060-53-3) he momo paturopi lipopeptide cyclic me te hanganga hou.Ka tangohia mai i te hupa fermentation Streptomyces.I kitea e te Kamupene Eli Lilly i te tekau tau atu i 1980, a i angitu te whakawhanake i te tau 1997 e Cubist Pharmaceuticals.Ehara i te mea he hanganga matū hou engari he momo mahi he rereke mai i nga paturopi kua whakaaetia i mua: ka aukati i nga pūtau ma te whakararu i te kawe o nga waikawa amino ma roto i te membrane pūtau, na reira ka aukati i te peptidoglycan biosynthesis pakitara pūtau me te huri i te ahua o te kiriuhi pūtau.Ka taea e ia te whakakore i te mahi membrane pūtau huakita i roto i nga waahanga maha, ka tere te patu i nga huakita karamu-pai.I tua atu i te whai mana ki te nuinga o nga huakita karamu-pai e pa ana ki te haumanu, ko te mea nui ake, he kaha te kaha o te Daptomycin ki te rongoa i nga riu taratahi kua kitea nga tohu o te aukati ki te methicillin, vancomycin me te linezolid.He tino hiranga haumanu tenei taonga mo nga turoro e mate ana i te mate kino.I te marama o Hepetema 2003, i whakaaetia e te US Food and Drug Administration mo te wa tuatahi ka taea te tono a Daptomycin (CAS: 103060-53-3) mo te maimoatanga o nga mate kiri kino.I te Maehe 2006, i whakaaetia mo te rongoa i nga mate hopuhopu.I te marama o Hanuere 2006, ka whakaaetia e te Komihana Pakeha mo te maimoatanga o etahi mate kiri uaua me nga mate ngohe na te huakita karamu pai.I te Hepetema 6, 2007, Cubist Pharmaceuticals i kii kua whakaaetia e te Kotahitanga o Europi tana tarukino antibacterial, Cubicin mo te maimoatanga o te endocarditis ngakau matau na te mate Staphylococcus aureus me te kiri uaua me te mate o te kiko ngohengohe e pa ana ki nga mate e pa ana ki te Staphylococcus aureus.