Darunavir Ethanolate CAS 635728-49-3 Purity ≥99.0% API Factory Anti-HIV HIV Protease Inhibitor
Kaihanga Kaihanga Darunavir Hua e Pa ana:
Darunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
(2S,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98737-29-2
(2R,3S)-1,2-Epoxy-3-(Boc-Amino)-4-Phenylbutane CAS 98760-08-8
(3S)-3-(tert-Butoxycarbonyl)amino-1-Chloro-4-Phenyl-2-Butanone CAS 102123-74-0
| Ingoa matū | Darunavir Ethanolate |
| Nga kupu taurite | DRV;Prezista;TMC114 Ethanolate;UNII-33O78XF0BW;N-[(1S,2R)-3-[[(4-Aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]carbamic acid (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl ester compd.me te waihā |
| Tau CAS | 635728-49-3 |
| Tau CAT | RF-API69 |
| Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
| Tātai rāpoi | C29H43N3O8S |
| Taumaha rāpoi | 593.73 |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Te Paura Maama, Maama-Ma ranei |
| Tautuhinga IR | He rite ki te Paerewa Spectrum |
| Hurihuri Tauwhāiti | -0.5°~ +0.5° |
| Nga Taonga Paanga | (na HPLC) |
| Max Single poke | ≤0.20% |
| Nga poke katoa | ≤0.50% |
| Wai (KF) | ≤1.0% |
| Te toenga i runga i te mura | ≤0.10% |
| Nga Korewa Taamaha | ≤10ppm |
| Ihirangi o te Ewaro | ≤7.5% (GC) |
| Wairewa toenga | Mewaro ≤0.30% |
| Maamaa | ≥99.0% (HPLC) |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
Mōkī: Pounamu, Peeke konumohe konumohe, Paera Kaata, 25kg / Paera, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko te Darunavir Ethanolate (Prezista) he aukati protease HIV.Te whakaputanga o Darunavir, he reanga tuarua HIV-1-protease inhibitor;he rite tonu te hanganga ki te amprenavir.Antiviral.He hua rangahau e pa ana ki te COVID19.Kia aroha mai, he iti te wairewa o te DRV i roto i te wai me te iti o te waatea o te koiora, na reira me whakahaere i roto i nga pota tino nui kia kitea ai te kaha o te rongoa.Ko Darunavir he aukati kaha-a-whaanui e kaha ana ki nga momo haumanu HIV-1 me te iti o te cytotoxicity.Ka hangaia e Darunavir nga here hauwai me nga ngota mekameka matua kua tiakina o Asp29 me Asp30 o te porotease.Ko enei taunekeneke e whakaarohia ana he mea tino nui mo te kaha o tenei puhui ki nga momo mate HIV e atete ana ki nga aukati protease maha.I roto i te rangahau in vitro i roto i nga ruma MT-2, he nui ake te kaha o te darunavir i tera o saquinavir, amprenavir, nelfinavir, indinavir, lopinavir me ritonavir.Ko te Darunavir ko te mea tuatahi ka whakakorikorihia e te hepatic cytochrome P450 (CYP) enzymes, te nuinga o te CYP3A.Ko te 'whakanui' te horopeta o te ritonavir ka mahi hei aukati i te CYP3A, na reira ka piki ake te koiora darunavir.I hangaia a Darunavir ki te hanga i nga taunekeneke pakari me te enzyme protease mai i te maha o nga taumahatanga o te HIV, tae atu ki nga taumahatanga mai i nga turoro kua mohio ki te maimoatanga he maha nga mutati aukati.
