Waikawa Diethylphosphonoacetic CAS 3095-95-2 Purity >99.5% (HPLC) Afatinib Dimaleate Intermediate Factory

Whakaahuatanga Poto:

Ingoa matū: Diethylphosphonoacetic Acid

CAS: 3095-95-2

Maamaa: >99.5% (HPLC)

Te ahua: Wai Taekore

Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

Kounga Teitei, Hanganga Aromoni

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ruifu Chemical Supply Takawaenga o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
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trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Waikawa Diethylphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Ngā Āhuatanga matū:

Ingoa matū	Waikawa Diethylphosphonoacetic
Nga kupu taurite	2-(Diethoxyphosphoryl)Acetic Waikawa;(Diethoxyphosphinyl)Acetic Waikawa;Diethyl Carboxymethylphosphonate;NSC 272281
Tau CAS	3095-95-2
Tau CAT	RF-PI2024
Tūnga Taonga	I roto i te Raarangi, Te Whakaputa Whakaputa 30MT/Marama
Tātai rāpoi	(C2H5O)2P(O)CH2CO2H
Taumaha rāpoi	196.14
Kohuatanga	150 ℃/0.05 mmHg (marama)
Kiato	1.220 g/mL i te 25 ℃ (marama)
Taurangi Refactive	n20/D 1.445 (marama)
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Wai Taekore
Tautuhi (HPLC)	Ko te wa pupuri o te tihi matua ka riro mai i te tauira kei roto i te 5% o te tauira tohutoro.
Te Maama / Tikanga Tatauria	>99.5% (HPLC)
Spectrum Infrared	He rite ki te Hanganga
Proton NMR Spectrum	He rite ki te Hanganga
makuku (KF)	<0.50%
Nga poke katoa	<0.50%
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

Mōkī me te Rokiroki:

Mōkī: Pounamu Fluorinated, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

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Taupānga:

Diethylphosphonoacetic Acid (CAS: 3095-95-2), Ka mahi hei nucleophile mo nga tauhohenga taapiri nucleophilic mo te whakahiato o nga epoxide allene Reactant mo: Nga rangahau stereoselectivity o te tauhohenga a Staudinger;Ko te hanganga enantioselective o nga diols na roto i te epoxidation me te hydration tauhohenga;Horner-Wadsworth-Emmons tauhohenga;Kei te whakahaeretia e te chelation mamao a Ireland-Claisen te whakatikatika;Ko nga tauhohenga Ugi-Dieckmann mo te whakahiatotanga o nga paheketanga waikawa tetramic;I whakamahia hei hanga takawaenga phosphonoester mo nga tauhohenga HEW intramolecular.Ko te Diethylphosphonoacetic Acid he takawaenga o Afatinib Dimaleate (CAS: 850140-73-7).I whakaaetia a Afatinib Dimaleate e te US Food and Drug Administration (FDA) i te tau 2013 mo te maimoatanga o te mate pukupuku mate pukupuku kore-iti (NSCLC).Ko te mea motuhake, i whakaaetia mo nga turoro e mau ana i nga pukupuku NSCLC metastatic kei roto i te epidermal growth factor receptor (EGFR) exon deleted exon 21 ranei.Ko te Afatinib Dimaleate he kaitao whakakorikori o te ErbB tyrosine kinases (tyk), e whakaheke ana i te tohu ErbB ma te herenga korekore o nga waahi here EGFR tyk.