Entecavir Monohydrate CAS 209216-23-9 wheketere API Te Kounga Teitei Te Waahanga Paatete B Antiviral
Ko te Kaihanga Kaihanga me te Maama me te Kounga Pumau
Ingoa matū: Entecavir Monohydrate
CAS: 209216-23-9
Ka whakamahia mo te maimoatanga o te mate Hepatitis B
API Kounga Teitei, Hanganga Tauhokohoko
Ingoa matū | Entecavir Monohydrate |
Nga kupu taurite | Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3-(hydroxymethyl)-2-methylenecyclopentyl]guanine Monohydrate |
Tau CAS | 209216-23-9 |
Tau CAT | RF-API79 |
Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
Tātai rāpoi | C12H17N5O4 |
Taumaha rāpoi | 295.3 |
Iwi Whakarewa | >220℃ |
Kiato | 1.81 |
Tikanga Tukunga | Ka tukuna i raro i te pāmahana ambient |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Paura ma, tata ma ranei te kirikiriata |
Wairewa | Ka Rere noa i roto i te Dimethylformamide, He iti te Rere ki te Wai, te Ewaro me te Mewaro |
Tautuhinga IR | He rite te hihinga o te tauira ki te paerewa tohutoro |
Tautuhinga HPLC | Ko te wa pupuri o te tauira whakamatautau ka rite ki tera o te paerewa tohutoro |
Ihirangi Wai (na KF) | 5.5%~6.5% |
Hurihanga Optical Tauwhāiti | +24.0° ki te +30.0° (DMF: MeOH=1:1 C=1%) (i runga i te matū waikore) |
Te toenga i runga i te mura | ≤0.10% |
Nga Taonga Paanga | |
Furoentecavir | ≤0.10% |
Entecavir 1-Epimer | ≤0.10% |
Entecavir 3-Epimer | ≤0.10% |
8-Methyoxy Entecavir | ≤0.10% |
Entecavir 4-Epimer | ≤0.10% |
8-Hydroxy Entecavir | ≤0.10% |
4-Dimethylsilyl Entecavir | ≤0.10% |
Entecavir Related Compound A | ≤0.10% |
Tetahi poke kore i tohua | ≤0.10% |
Nga poke katoa | ≤0.30% |
Wairewa toenga | |
Mewaro | ≤600ppm |
Dichloromethane | ≤300ppm |
Ethyl Acetate | ≤1000ppm |
Tetrahydrofuran | ≤720ppm |
Toluene | ≤890ppm |
Benzyl Chloride | ≤1000ppm |
Benzyl Alcohol | ≤1000ppm |
Tepe Microbial | |
Tatau Aerobic Tapeke | ≤100cfu/g |
Rewena me nga Maaka | ≤10cfu/g |
Escherichia Coli | Kaua e kitea |
Nga Korewa Taamaha | ≤10ppm |
Te whakamatautau | 98.0%~102.0% (HPLC; i runga i te tikanga anhydrous) |
Rahi Matūriki | 95% o nga matūriki me noho i roto i te 125um |
Paerewa Whakamatau | Paerewa hinonga;United States Pharmacopoeia (USP) Paerewa |
Whakamahinga | Ko te rongoa pareketo e whakamahia ana mo te maimoatanga o te mate Hepatitis B |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
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Ko te Entecavir Monohydrate (CAS 209216-23-9) he rongoa parepare-a-waha e whakamahia ana hei rongoa i te mate Hepatitis B Virus (HBV).Ko te Entecavir Monohydrate he tairitenga nucleoside (he mea nui ake, he tairitenga guanine) e aukati ana i te whakamaoritanga whakamuri, te tukurua DNA me te tuhi i roto i te vira.He momo hou o nga raau taero cyclopentyl acyl guanosine anti-Hepatitis B me ona hua rongoa rite ki te Entecavir.Ka whakamahia e te haumanu ki te maimoatanga o te mate Hepatitis B pakeke e kaha ana te tukuruatanga viral, te pikinga o te serum transaminase ALT, nga reinga kaha ranei i kitea mai i te hitori o te ate.Ko te Entecavir Monohydrate he aukati kaha me te whiriwhiri o te HBV, me te EC50 o 3.75 nM i roto i te HepG2 pūtau.Ko te Entecavir he aukati transcriptase whakamuri.Ka aukati i te Hepatitis B Virus (HBV) mai i te tini me te whakaiti i te nui o te huaketo i roto i te tinana.
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