Flurbiprofen CAS 5104-49-4 Assay 99.0~100.5% (HPLC) Factory

Flurbiprofen
C15H13FO2 244.27
(±)-2-(2-Fluoro-4-biphenylyl) waikawa propionic [5104-49-4].
Ko te Flurbiprofen kaua e iti iho i te 99.0 paiheneti, kaua hoki e neke ake i te 100.5 paiheneti o C15H13FO2, ka tatauhia i runga i te tikanga whakamaroke.
Te takai me te rokiroki- Tiakina i roto i nga ipu kiki.
Paerewa Tohutoro USP <11>-
USP Flurbiprofen RS
USP Flurbiprofen Related Compound A RS
2-(4-Biphenylyl)waikawa propionic.
C15H14O2 226.28
Tautuhinga-
A: Whakangao Infrared <197K>.
B:Ultraviolet Absorption 197U-
Rongoā: 10 µg ia mL.
Waenga: 0.1 N konutai waihā.
Ko te teitei o te absorbance i te 247 nm he 0.8 pea.
Awhe whakarewa <741>: i waenganui i te 114 me te 117.
Ngaronga i runga i te whakamaroke <731>-Ka whakamaroke ki te korehau i te 60 ki te taumaha tonu: ka ngaro i te 0.5% o tona taumaha.
Te toenga i runga i te mura <281>: kaua e neke ake i te 0.1%.
Nga konganuku taumaha, Tikanga II <231>: 0.001%.
Pūhui pā-
Diluent-Whakaritea he ranunga o te wai me te acetonitrile (11:9).
Wāhanga pūkoro-Whakaritea he ranunga kua tātarihia, kua whakakorehia hoki te wai, te acetonitrile, me te waikawa acetic glacial (12:7:1).Whakaritea nga whakarereketanga mehemea e tika ana (tirohia te Whakaaetanga Pūnaha i raro i te Chromatography <621>).
Wairewa kararehe paerewa- Whakarewahia te rahinga tika o te USP Flurbiprofen Related Compound A RS i roto i te Diluent kia whiwhi ai i tetahi otinga he 50 µg ia mL.
Te otinga pai o te punaha-Pipet 2.0 mL o te wairewa rakau Paerewa ki roto i te ipu 10-mL, taapirihia te 20 mg o USP Flurbiprofen RS, waimeha ki te Diluent ki te rōrahi, ka uru.
Wairewa Paerewa-Whakawhitihia te 2.0 mL o te wairewa rakau Paerewa ki te ipu 10.0-mL, waimeha ki te Diluent ki te rōrahi, ka uru.
Te otinga whakamatautau-Whakaritea he otinga o Flurbiprofen i roto i te Diluent kei roto 2.0 mg ia mL.
Pūnaha Chromatographic (tirohia te Chromatography <621>)-Ko te chromatograph wai he mea whakakakahu ki te 254-nm kaitahuri me te 3.9-mm × 15-cm tīwae kei roto 4-µm tarapi L1.Ko te tere rere he 1 mL ia meneti.Chromatograph te otinga pai o te Pūnaha, me te tuhi i nga whakautu teitei e kiia ana mo te Tikanga: ko nga wa pupuri whanaunga he 0.9 mo te Flurbiprofen pūhui A me te 1.0 mo te flurbiprofen;a ko te inenga paerewa mo nga werohanga tukurua kaua e neke ake i te 1.0%.
Tikanga-Tukuhia wehe nga pukapuka rite (mo te 20 µL) o te otinga Paerewa me te otinga Whakamatau ki te chromatograph, tuhia nga chromatograms, me te ine i nga waahi mo nga tihi nui.Tātaihia te ōrau o te pūhui A flurbiprofen i te wāhanga o te Flurbiprofen i tangohia e te tātai:
100(CS / CU)(rU / rS)
kei roto ko CS te kukū, i roto i te µg ia mL, o te USP Flurbiprofen Related Compound A RS i roto i te otinga Paerewa;Ko te CU te kukū, i te µg ia mL, o Flurbiprofen i roto i te otinga Whakamatau;a ko rU me rS nga whakautu teitei mo te flurbiprofen e pa ana ki te puhui A i whiwhi mai i te otinga Whakamatau me te otinga Paerewa: kaua e neke ake i te 0.5% o te puhui A e pa ana ki te flurbiprofen.Tātaihia te ōrau o ia poke i te wāhanga o Flurbiprofen i tangohia e te tātai:
100(ri / rs)
kei te ri ko te whakautu teitei mo ia poke i puta mai i te otinga Whakamatau;a ko te rs te tapeke o nga whakautu o nga tihi katoa i puta mai i te otinga Whakamatau: ko te tapeke o nga poke katoa kaua e neke ake i te 1.0%.
Whakamatau-Whakarewa mo te 0.5 g o Flurbiprofen, i tika te pauna, ki te 100 mL o te waipiro, i whakakorea i mua ki te 0.1 N konutai waikawa VS ki te pito mutunga o te phenolphthalein, taapirihia te phenolphthalein TS, me te titrate ki te 0.1 N konutai waiwaro VS ki te ahua tuatahi o te ngohe. tae māwhero e mau tonu ana kia kaua e iti iho i te 30 hēkona.Ko ia mL o te 0.1 N konutai waikawa he rite ki te 24.43 mg o C15H13FO2.