Fondaparinux Sodium CAS 114870-03-0 API
Whakarato me te Maama me te Kounga Pumau
Ingoa matū: Fondaparinux Sodium
CAS: 114870-03-0
He Anticoagulant Antithrombotic, he Taonga Xa Inhibitor
API Kounga Teitei, Hanganga Tauhokohoko
Ingoa matū | Fondaparinux konutai |
Tau CAS | 114870-03-0 |
Tau CAT | RF-API84 |
Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
Tātai rāpoi | C31H43N3O49S8.10Na |
Taumaha rāpoi | 1728.08 |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura-White |
Tikanga Whakamatau / Tatau | 95.0%~103.0% (i runga i te tikanga maroke) |
Wairewa | Ka Rere noa ki te wai, 2.0M konutai pūhaumāota me te 0.5M konutai waiwaro me te koretake ki te waihā |
Tautuhi 13C-NMR | Ko nga resonances mo te Fondaparinux Sodium me kite i te 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7 me te 176.7.Ko nga nekehanga matū o enei tohu kaore e rereke i te neke atu i te ± 0.3ppm etahi atu tohu o te teitei taurangi me nga nekehanga matū, e pa ana ki te Fondaparinux Sodium, ka kitea pea i waenga i te 58.0~80.5 ppm me te 98.7~104.5ppm |
Tautuhinga HPLC | Ko te wa pupuri o te tihi nui o te otinga tauira e rite ana ki tera o te otinga paerewa |
Tautuhinga AAS | Ko te konutai me whai ahuatanga te whakaurunga i te 330.2nm i raro i te whakatau o te konutai |
pH | 6.0~8.0 |
Konutai (Na) | 11.5%~15.0% (Kua tatauhia i runga i te waikore me te whakarewa kore utu) |
Waatea Waatea | ≤0.30% |
Te toenga pūhaumāota | ≤1.00% |
Nga Taonga Paanga | |
Te poke A | ≤0.80% |
Te poke B | ≤0.60% |
Takitahi Ētahi atu poke | ≤0.30% |
Nga poke katoa | ≤2.00% |
Wairewa toenga | |
Mewaro | ≤3000ppm |
Ewaro | ≤5000ppm |
Ethyl Acetate | ≤5000ppm |
DMF | ≤880ppm |
Methylbenzene | ≤890ppm |
Pyridine | ≤50ppm |
Ihirangi wai (KF) | ≤15.0% |
Endotoxins huakita | ≤3.3EU/mg |
Tepe Microbial | Te tapeke o nga Microorganisms ≤100cfu/g |
Paerewa Whakamatau | Paerewa hinonga;United States Pharmacopoeia (USP) Paerewa |
Whakamahinga | API, He Anticoagulant Antithrombotic, he Taonga Xa Inhibitor |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
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Ko te Fondaparinux Sodium (CAS 114870-03-0) te tuatahi o te karaehe hou o te antithrombotic anticoagulant matū e pa ana ki nga heparins iti ngota ngota (LMWH).Ko te konutai Fondaparinux he aukati Xa hei hanga i te waahi herenga hononga teitei mo te take anti-coagulant antithrombin III (ATIII).Ko te herenga konutai Fondaparinux i tenei waahi ka kaha te aukati o te ATIII ki te tauwehe Xa ma te ahua o te 300, e hua ana te aukati i te whakatipuranga thrombin.Kei te maakete e GlaxoSmithKline.Ko tetahi putanga whanui i hangaia e Alchemia ka hokona i roto i te US e Dr. Reddy's Laboratories.Ko te konutai Fondaparinux i whakauruhia tuatahi ki te US mo te aukati i te thrombosis o nga uaua hohonu ka pa mai pea ki te pulmonary embolism i muri i nga pokanga orthopedic nui.He kape o te raupapa pentasaccharide heparin, te kongakonga poto rawa atu ka taea te whakakorikori i te antithrombin me te aukati i te tauwehe Xa ma reira ka aukati i te whakatipuranga thrombin me te kore he mahi antithrombin.
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