Fulvestrant (ICI 182780) CAS 129453-61-8 API Factory Kounga teitei
Ko te Kaihanga Kaihanga me te Maama me te Kounga Pumau
Ingoa: Fulvestrant
CAS: 129453-61-8
Ka whakamahia te Fulvestrant ki te maimoatanga o te mate pukupuku u tairongo tairongo i roto i nga wahine kua pahemo.
API Kounga Teitei, Hanganga Tauhokohoko
Ingoa matū | Fulvestrant |
Nga kupu taurite | (7α,17β)-7-[9-[(4,4,5,5,5-Pentafluorpentyl)sulfinyl]nonyl]estra-1,3,5(10)-trien-3,17-diol;ICI 182780 |
Tau CAS | 129453-61-8 |
Tau CAT | RF-API81 |
Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
Tātai rāpoi | C32H47F5O3S |
Taumaha rāpoi | 606.77 |
Iwi Whakarewa | 104.0~106.0℃ |
Wairewa | Wairewa ki te Methanol, Ethanol;Karekau ki te wai |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura Tioata-White |
Tautuhinga | Na IR, HPLC |
Hurihanga Optical Tauwhāiti | +108.0° ki te +115.0° |
Ngaronga i te whakamaroke | ≤0.50% |
Te toenga i runga i te mura | ≤0.10% |
6-Keto-Fulvestrant | ≤0.10% |
6,7-Fulvestrant | ≤0.10% |
Fulvestrant Sulfone | ≤0.20% |
Fulvestrant Whakaroa | ≤0.30% |
Fulvestrant Sterol Dimmer | ≤0.80% |
Te Tangata Tangata Kore I Whakapuketia | ≤0.10% |
Nga poke katoa | ≤1.0% |
Fulvestrant A | 42.0%~48.0% |
Fulvestrant B | 52.0%~58.0% |
DMF | ≤620ppm |
Nga Korewa Taamaha | ≤10ppm |
Te whakamatautau | 97.0%~102.0% (i runga i te tikanga maroke) |
Rokiroki | Whakaorangia i roto i te toa katia pai-a-te-maamaa i roto i te pouaka whakamātao i te 2~8 ℃ |
Paerewa Whakamatau | United States Pharmacopoeia (USP) Paerewa |
Whakamahinga | Estrogen Receptor Antagonist |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko Fulvestrant (ICI-182780) CAS 129453-61-8, he rongoa werohanga uaua i whakawhanakehia e te kamupene AstraZeneca ka whakamahia ki te maimoatanga o te mate pukupuku u tairongo tairongo i roto i nga wahine kua pahemo.Ko Fulvestrant anake te rongoa antiestrogen ka taea te whakamahi whanui i te haumanu whai muri i nga maimoatanga tamoxifen kaore i angitu.Ko tenei rongoa he momo rongoa endocrine, no reira kare e puta he paanga kino e kitea ana i roto i te chemotherapy, e pai ai te tautukunga o te manawanui.He maha nga whakamatautau haumanu kua kitea he whai hua te 250mg Fulvestrant me te haumaru tonu hei rarangi tuarua mo te maimoatanga mo te mate pukupuku uma.Ko Fulvestrant he Antagonist Estrogen Receptor (ER) Antagonist me te IC50 o te 0.94 nM i roto i te whakamatautau-kore-kore.Ko te Fulvestrant ano e whakaawe i te autophagy me te apoptosis me te mahi antitumor.