Ibrutinib CAS 936563-96-1 Purity >99.5% (HPLC) API

Whakaahuatanga Poto:

Ingoa matū: Ibrutinib

CAS: 936563-96-1

Maamaa: >99.5% (HPLC)

Te ahua: Ma ki te Paura Kiriata-White

Ko te Ibrutinib he aukati BTK e whakamahia ana ki te hamani Chronic Lymphocytic Leukemia (CLL) me Mantle Cell Lymphoma (MCL)

Whakapā: Takuta Alvin Huang

Pūkoro/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ngā Āhuatanga matū:

Ingoa matū	Ibrutinib
Nga kupu taurite	1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1- kotahi;PCI-32765
Tau CAS	936563-96-1
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C25H24N6O2
Taumaha rāpoi	440.50
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Ma ki te Paura Kiriata-White
Tautuhinga	IR;HPLC
Ngaronga i te whakamaroke	<0.50%
Te toenga i runga i te mura	≤0.10%
Konga Taamaha (hei Pb)	≤20ppm
Tetahi poke kotahi	≤0.20%
Nga poke katoa	<0.50%
Te Maama / Tikanga Tatauria	>99.5% (HPLC)
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	API

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku.

Painga:

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Taupānga:

Ko te Ibrutinib (CAS: 936563-96-1) he aukati i te Bruton tyrosine kinase (BTK) mo te maimoatanga o te mate pukupuku lymphocytic tawhito (CLL) me te lymphoma pūtau koroka (MCL).Ko te MCL me te CLL e rua no te lymphoma kore-Hodgkin o te pūtau-B, he whakakeke, he ngawari ki te hoki.Ko te whakamaarama haumanu e whakamahia nuitia ana kaore i te arohia, a he maha nga wa ka puta nga tauhohenga kino o te reanga 3, 4 ranei.Ka taea e Ibrutinib te whakakotahi me te BTK, he mea tika mo te hanganga, te rereketanga, te whakawhitiwhiti korero me te oranga o nga lymphocytes B, me te aukati i te mahi o te BTK, ka whai hua ki te aukati i te tipu me te oranga o nga pukupuku pukupuku.I tua atu, ka tere te whakauru i muri i te whakahaere a-waha, ka tae te nui o te plasma plasma ki te 1 ~ 2h, a ko nga tauhohenga kino he tohu 1, 2 ranei, ka waiho hei waahanga hou mo te maimoatanga o te CLL me te MCL.I te Whiringa-a-rangi 13, 2013, te US FDA ki te whakatere i te kamupene Johnson & Johnson kua whakaaetia me te United States Imbruvica (ingoa noa: Ibrutinib) mo te maimoatanga o te lymphoma pūtau koroka (MCL).Ibrutinib, i whakawhiwhia e te FDA te mana Haumarutanga pakaruhanga i te Hui-tanguru 2013 ka whakaaetia mo MCL i te Noema 13, 2013 me CLL i te Hui-tanguru 12, 2014, ia.