N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS 152460-09-8 Imatinib Mesylate Intermediate High Pure
Tukunga Arumoni Imatinib Mesylate me nga Kaiwaenga Paanga:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4- [(4-Methylpiperazin-1-yl)methyl] waikawa benzoic dihydrochloride CAS: 106261-49-8
Ingoa matū | N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pirimidin-2-amine |
Nga kupu taurite | Imatinib Mesylate Intermediate;2-(2-Methyl-5-nitroanilino)-4-(3-pyridyl)pirimidine |
Tau CAS | 152460-09-8 |
Tau CAT | RF-PI228 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C16H13N5O2 |
Taumaha rāpoi | 307.31 |
Te Whakarewa | 188.0~193.0℃ |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Paura Kōwhai, Tata Kowhai ranei |
Maamaa | ≥98.0% (HPLC) |
makuku (KF) | ≤0.50% |
Nga poke katoa | ≤2.0% |
Mōrahi Kore kotahi | ≤1.0% |
Te toenga i runga i te mura | ≤0.50% |
Nga Korewa Taamaha | ≤20ppm |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | Takawaenga o Imatinib Mesylate (CAS: 220127-57-1) |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
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Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua me te kaiwhakarato o N-(2-Methyl-5-nitrophenyl) -4-(pyridin-3-yl)pyrimidin-2-amine (CAS: 152460-09-8) me te kounga teitei.He takawaenga i te nuinga o te wa i te whakahiatotanga o Imatinib Mesylate (CAS: 220127-57-1).
Ko te Imatinib Mesylate he ngota ngota iti e aukati ana i te c-Abl protein-tyrosine kinase, He mea tino motuhake mo te BCR-ABL, te enzyme e pa ana ki te reukemia myelogenous ma'i (CML) me etahi momo o te mate lymphoblastic leukemia (KATOA).He takahanga whakawhiti i waenga i nga chromosomes 9 me te 22 ka whakaputa i te chromosome Philadelphia, katahi ka whakaputa i te pūmua whakakotahi Bcr-Abl me te ngohe kinase aberrant e whakatairanga ana i te tipu tere o te pūtau.Ka herea e Imatinib Mesylate tenei kinase whakahirahira, ka aukati i te tipu o te CML.Kua whakaatuhia ano te Imatinib Mesylate ki te aukati i te PDGFR me te tyrosine kinases e hono ana ki te c-Kit.Kua whakamahia nga rongoa kei roto Imatinib Mesylate ki te rongoa i nga momo mate pukupuku.