N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Pure
Tukunga Arumoni Imatinib Mesylate me nga Kaiwaenga Paanga:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4- [(4-Methylpiperazin-1-yl)methyl] waikawa benzoic dihydrochloride CAS: 106261-49-8
| Ingoa matū | N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea |
| Nga kupu taurite | Imatinib Mesylate Intermediate;2-(5-Amino-2-methylanilino)-4-(3-pyridyl)pirimidine |
| Tau CAS | 152460-10-1 |
| Tau CAT | RF-PI230 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C16H15N5 |
| Taumaha rāpoi | 277.32 |
| Te Whakarewa | 133.0-135.0 ℃ |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Karaka Maama ki te Paura Kowhai ki te Kiriata |
| Te Maama / Tikanga Tatauria | ≥98.0% |
| Ngaronga i te whakamaroke | ≤0.50% |
| Te toenga i runga i te mura | ≤0.50% |
| Nga poke katoa | ≤2.0% |
| Mōrahi Kore kotahi | ≤1.0% |
| Nga Korewa Taamaha | ≤20ppm |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Takawaenga o Imatinib Mesylate (CAS: 220127-57-1) |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua me te kaiwhakarato o N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) me te kounga teitei .
Ko te N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea (CAS: 152460-10-1) he takawaenga i te nuinga o te wa i te whakahiato o Imatinib Mesylate (CAS: 220127-57-1) ) API.
Ko te Imatinib mesylate he ngota ngota iti e aukati ana i te c-Abl protein-tyrosine kinase, he kinase e tino nui ana mo te tipu o te mate pukupuku myelogenous tawhito (CML).He takahanga whakawhiti i waenga i nga chromosomes 9 me te 22 ka whakaputa i te chromosome Philadelphia, katahi ka whakaputa i te pūmua whakakotahi Bcr-Abl me te ngohe kinase aberrant e whakatairanga ana i te tipu tere o te pūtau.Ka herea e Imatinib mesylate tenei kinase whakahirahira, ka aukati i te tipu o te CML.Kua whakaatuhia ano te Imatinib mesylate ki te aukati i te PDGFR me te tyrosine kinases e hono ana ki te c-Kit.Kua whakamahia nga waihanga kei roto Imatinib mesylate ki te rongoa i nga momo mate pukupuku.
Ko te Imatinib mesylate he aukati tyrosine kinase.He mea tino motuhake mo te BCR-ABL, te whaakiki e pa ana ki te kano kano mielogenous ma'i (CML) me etahi momo mate pukupuku lymphoblastic acute (KATOA).Ko te v-Abl tyrosine kinase inhibitor kaha me te whiriwhiri (IC50 = 38 nM).Ka aukati ano i te PDGFR me te c-kit.Ka whakaatu i te whiriwhiringa mo te v-Abl i runga i te roopu o etahi atu kinases pūmua tyrosine me te serine/threonine.Ka whakakorehia te tipu o te PDGF-whakaongaonga o te v-abl-whakahuri PB-3 pūtau me te v-sis-hurihia BALB/c 3T3 pūtau in vitro.Ka whakaatu i nga paanga antitumor i roto i nga kiore e mau ana i te AMuLV, i te BBL/c 3T3 v-sis ranei.Ka aukati i te tukurua o SARS-CoV me MERS-CoV in vitro (ko nga uara EC50 he 9.823 me te 17.689 μM, ia).
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Pure](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)