Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory Kounga Teitei
Tukunga Arumoni Imatinib Mesylate me nga Kaiwaenga Paanga:
Imatinib Mesylate CAS: 220127-57-1
N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine CAS: 152460-09-8
N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinea CAS: 152460-10-1
4- [(4-Methylpiperazin-1-yl)methyl] waikawa benzoic dihydrochloride CAS: 106261-49-8
| Ingoa matū | Imatinib Mesylate (ahua alpha) |
| Nga kupu taurite | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| Tau CAS | 220127-57-1 |
| Tau CAT | RF-API19 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C30H35N7O4S |
| Taumaha rāpoi | 589.71 |
| Tikanga Tukunga | I raro i te Paemahana Ambient |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Ma ki te Paura Tioata-White |
| Wairewa | He ngawari ki te memeha i roto i te wai |
| Tautuhinga HPLC | Ko nga tauira o te waa pupuri tihi matua e rite ana ki tera |
| IR Identification | Ko te hihinga whakauru infrared o te tauira e rite ana ki te tauira tohutoro |
| Iwi Whakarewa | 214.0~222.0℃ |
| Ngaronga i te whakamaroke | ≤0.50% |
| Te toenga i runga i te mura | ≤0.10% |
| Nga Korewa Taamaha | ≤20ppm |
| Nga Taonga Paanga | (1) Parakore G: NMT 0.3% |
| (2) Parakore B: NMT 0.3% | |
| (3) Parakore C: NMT 0.3% | |
| (4) Parakore D: NMT 0.3% | |
| (5) poke A: NMT 0.3% | |
| (6) poke H: NMT 0.3% | |
| (7) Parakore F: NMT 0.3% | |
| (8) Parakore E: NMT 0.3% | |
| (9) Ko te tino poke kotahi: NMT0.1% | |
| Wairewa toenga | (1) Ethyl Acetate: NMT 5000ppm |
| (2) Mewaro: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ewaro: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| Te whakamatautau HPLC | 98.0%~102.0% (C30H35N7SO4 Kua Tātaihia i runga i te Kaupapa Anhydrous) |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | API;Ph+CML |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko te Imatinib Mesylate(CAS 220127-57-1) he ngota ngota iti e aukati ana i te c-Abl protein-tyrosine kinase, he kinase e tino nui ana mo te whakatipuranga o te mate pukupuku myelogenous tawhito (CML).He mea tino motuhake mo te BCR-ABL, te whaakiki e pa ana ki te kano kano mielogenous ma'i (CML) me etahi momo mate pukupuku lymphoblastic acute (KATOA).Ko te v-Abl tyrosine kinase inhibitor kaha me te whiriwhiri (IC50 = 38 nM).He takahanga whakawhiti i waenga i nga chromosomes 9 me te 22 ka whakaputa i te chromosome Philadelphia, katahi ka whakaputa i te pūmua whakakotahi Bcr-Abl me te ngohe kinase aberrant e whakatairanga ana i te tipu tere o te pūtau.Ka herea e Imatinib mesylate tenei kinase whakahirahira, ka aukati i te tipu o te CML.Kua whakaatuhia ano te Imatinib mesylate ki te aukati i te PDGFR me te tyrosine kinases e hono ana ki te c-Kit.
![4-[(4-Methylpiperazin-1-yl)methyl]benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Pure](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)