Irinotecan Hydrochloride CAS 100286-90-6 Purity ≥99.0% (HPLC) API USP Paerewa Pure Teitei
Kaihanga Kaihanga Irinotecan me nga Takawaenga Paanga:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Ingoa matū | Irinotecan Hydrochloride |
| Nga kupu taurite | Camptothecin II;CPT-II |
| Tau CAS | 100286-90-6 |
| Tau CAT | RF-API50 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C33H39ClN4O6 |
| Taumaha rāpoi | 623.15 |
| Iwi Whakarewa | 250-256 ℃ (tikura) |
| Nga Tikanga Rokiroki | I raro i te Paemahana Ambient |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Paura Ma, Paura-Ma ranei |
| Wairewa | Wairewa ki te wai me te mewaro, paku wairewa ki te chloroform, waiwaro |
| Tautuhinga IR | Ko te awheawhe whakaurunga infrared o te tauira whakamatautau kia rite ki tera o te paerewa tohutoro |
| Tautuhinga HPLC | Ko te wa pupuri o te tihi nui o te tauira otinga kia rite ki tera o te paerewa tohutoro. |
| Tautuhinga | Ka tutuki nga whakaritenga o nga whakamatautau mo te tauhohenga pai o te Chloride |
| makuku (KF) | 7.0%~9.0% w/w |
| Te toenga i runga i te mura | ≤0.10% |
| Nga Korewa Taamaha | ≤20ppm |
| Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desetyl Irinotecan | ≤0.15% |
| Irinotecan Related Compound A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Irinotecan Related Compound B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| Tetahi poke kore i tohua | ≤0.10% |
| Nga poke katoa | ≤0.50% |
| Wairewa Toenga (GC) | |
| Mewaro | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500ppm |
| Peteoleum Etere: | ≤100ppm |
| Ethyl Acetate | ≤2000ppm |
| Benzene | ≤2ppm |
| Endotoxins huakita | ≤0.29 EU/mg Irinotecan |
| Nga Tepe Microbial | Kaute Moroiti Aerobic Tapeke: <1000 cfu/g |
| Moutere me te rewena | <100 cfu/g |
| Te Maama / Tikanga Tatauria | ≥99.0% (HPLC, i runga i te tikanga anhydrous) |
| Paerewa Whakamatau | United States Pharmacopeia (USP) Paerewa |
| Whakamahinga | Mahinga Rongoa Hohe (API) |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko te lrinotecan hydrochloride (CAS 100286-90-6), he mea hangarua, he wairewa wairewa o te camptothecin kaihoko mate pukupuku kaha, i whakarewahia ki Hapani mo te rongoa i nga mate pukupuku o te huhu, ovarian, me te whare pukupuku.Ka mahi a lrinotecan i tana mahi antitumor ma te aukati i te topoisomerase I, he whākōkī pūtau e whai wāhi ana ki te pupuri i te hanganga topographic o te DNA i te wa o te whakamaoritanga, te tuhi, me te mitosis.Ka tukuna a lrinotecan ki te whakakore-esterification i roto i te vivo kia puta he metabolite kaha, SN-38, he 1000-nui ake te kaha atu i te matua.Ko te rongoa whakakotahitanga o te irinotecan me tetahi atu rongoa mate pukupuku e whakamahia nuitia ana, ko te cisplatin, kua kii he pai ake i nga kaihoko anake.Kei roto a lrinotecan i nga whakamatautau haumanu mo te gastrointestinal, te uma, te kiri, te tae, nga mate pukupuku pancreatic, mesothelioma me te lymphoma kore-Hodgkin.
