Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API wheketere parakore teitei
Kaihanga Kaihanga Irinotecan me nga Takawaenga Paanga:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Ingoa matū | Irinotecan Hydrochloride Trihydrate |
| Nga kupu taurite | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Tau CAS | 136572-09-3 |
| Tau CAT | RF-API52 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C33H38N4O6·HCl·3H2O |
| Taumaha rāpoi | 677.20 |
| Iwi Whakarewa | 250.0~256.0 ℃ (tikura) |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Paura Kōwhai Kōwhai, Kōwhai Kōwhai rānei |
| Te whakamatautau (w/w) | 98.0%~102.0% |
| Pure (HPLC) | ≥99.5% |
| Wairewa | He iti te memeha ki te wai, te waiwaro, te chloroform ranei, Kare e memeha ki te acetone |
| Tautuhinga | na IR me HPLC, Whakaritea |
| Hurihanga Optical Tauwhāiti | +60°~+73° |
| Wai | 7.0%~9.0% |
| Te toenga o nga whakarewa | Ka tutuki ki nga Whakaritenga ICH |
| Te toenga i runga i te mura | ≤0.20% |
| pūhaumāota | 5.0%~6.0% |
| Uara pH | 3.0~5.0 |
| Nga Korewa Taamaha | ≤20ppm |
| Nga poke takitahi | ≤0.10% |
| Nga poke katoa | ≤0.50% |
| Tikanga Rokiroki | Rokiroki ki te 2-8°C, I roto i nga ipu kua hiri ka tiakina mai i te marama me te makuku |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Mahinga Rongoa Hohe (API) |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua me te kaiwhakarato o Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) me te kounga teitei.
Ko te Irinotecan Hydrochloride Trihydrate he aukati topoisomerase I te nuinga e whakamahia ana ki te rongoa i te mate pukupuku koroni me te mate pukupuku rectal, hei aukati i te herenga o te whenu DNA ma te here ki te topoisomerase I-DNA matatini.I whakarewahia te lrinotecan hydrochloride, he wai whakahiato, he wairewa wairewa mai i te camptothecin kaihoko mate pukupuku kaha, i Hapani hei rongoa i nga mate pukupuku o te huhu, ovarian, me nga mate pukupuku pukupuku.Ka mahi a lrinotecan i tana mahi antitumor ma te aukati i te topoisomerase I, he whākōkī pūtau e whai wāhi ana ki te pupuri i te hanganga topographic o te DNA i te wa o te whakamaoritanga, te tuhi, me te mitosis.Ka tukuna a lrinotecan ki te whakakore-esterification i roto i te vivo kia puta he metabolite kaha, SN-38, he 1000-nui ake te kaha atu i te matua.Ahakoa he iti ake te paitini i te camptothecin, he maha nga turoro i roto i nga whakamatautau haumanu i whakaatu i nga paanga o te leukopenia, te korere, te nauseahromiting, me te alopecia.Ko te rongoa whakakotahitanga o te irinotecan me tetahi atu rongoa mate pukupuku e whakamahia nuitia ana, ko te cisplatin, kua kii he pai ake i nga kaihoko anake.Kei roto a lrinotecan i nga whakamatautau haumanu mo te gastrointestinal, te uma, te kiri, te tae, nga mate pukupuku pancreatic, mesothelioma me te lymphoma kore-Hodgkin.
