Ketorolac Tromethamine CAS 74103-07-4 Purity >99.0% (HPLC)
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua me te kaiwhakarato o Ketorolac Tromethamine Salt (CAS: 74103-07-4) me te kounga teitei.Ka taea e matou te whakarato COA, te tuku i te ao, te iti me te rahinga e waatea ana.Mena kei te pirangi koe ki tenei hua, tukuna mai nga korero taipitopito ko te nama CAS, te ingoa hua, te rahinga ki a maatau.Please contact: alvin@ruifuchem.com
| Ingoa matū | Ketorolac Tromethamine |
| Nga kupu taurite | Ketorolac Tris Tote;Ketorolac (Tromethamine Salt);rac Ketorolac Tromethamine Tote;Toradol;(±)-5-Benzoyl-2,3-Dihydro-1H-Pyrrolizine-1-Carboxylic Acid Tris Tote;(±)-Whakaahua Tromethamine Tote |
| Tau CAS | 74103-07-4 |
| Tūnga Taonga | Kei roto i nga taonga, i hangaia ma te hokohoko |
| Tātai rāpoi | C15H13NO3·C4H11NO3 |
| Taumaha rāpoi | 376.41 |
| Iwi Whakarewa | 160.0~161.0 ℃ |
| Kohuatanga | 493.2 ℃ i te 760 mmHg |
| Tairongo | Hygroscopic.Maamaa Maamaa |
| λmax | 322nm(MeOH)(marama) |
| COA & MSDS | Kei te waatea |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Ma ki te Paura Tioata-White |
| pH | 5.7~6.7 |
| Iwi Whakarewa | 160.0~161.0 ℃ |
| Te Maama / Tikanga Tatauria | >99.0% (HPLC) |
| Tikanga Whakamatau / Tatau | 98.5~101.5% (Kua Tatauhia i runga i te Turanga maroke) |
| Ngaronga i te whakamaroke | <0.50% |
| Te toenga i runga i te mura | <0.10% |
| Konga Taamaha (Pb) | ≤20ppm |
| Nga Taonga Paanga | |
| Te poke RRT0.54 | <0.50% |
| Te poke RRT0.66 | <0.50% |
| Ketorolac 1-Keto Analog | <0.10% |
| Ketorolac 1-Hydroxy Analog | <0.10% |
| Tetahi atu poke kotahi | <0.20% |
| Nga poke katoa | <1.00% |
| Wairewa toenga | |
| Dichloroethane | <50ppm |
| Ewaro waiwaro | <5000ppm |
| Nga Tepe Microorganism | |
| Te nui o te huakita | <1000cfu/g |
| Te Maaka me te Rewena Rahi | <100cfu/g |
| Escherichia.Koi | Kei te ngaro |
| Endotoxin huakita | <5EU/mg |
| Spectrum Infrared | He rite ki te Hanganga |
| Wairewa i te H2O | Taekore ki te Kowhai Kowhai Maama (15 mg/ml) Haere |
| Paerewa Whakamatau | Paerewa hinonga |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Rokiroki i roto i te ipu kati kati.Rokiroki i roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
Nga maakete matua?Hokona ki te maakete kaainga, Amerika Te Tai Tokerau, Uropi, Inia, Korea, Hapani, Ahitereiria, aha atu.
Nga painga?Ko te kounga teitei, te utu utu, nga ratonga ngaio me te tautoko hangarau, te tuku tere.
KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.
Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.
MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.
Wā Tukunga? Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku.
Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.
Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.
Whakaritenga Whakaritenga?Ka taea te whakarato ratonga whakahiato ritenga kia pai ai to hiahia rangahau.
Nga tikanga utu?Ko te nama Proforma ka tukuna tuatahi i muri i te whakapumautanga o te ota, ka kohia o maatau korero peeke.Te utu ma te T/T (Telex Transfer), PayPal, Western Union, etc.
Ko te Tote Ketorolac Tromethamine (CAS: 74103-07-4) he kaihoko antiinflammatory nonsteroidal e whakaatu ana i te mahi analgesic me te mahi antipyretic.He aukati COX kore-whiriwhiri me nga IC50 o 20 nM mo te COX-1 me te COX-2.Ko te Tote Ketorolac Tromethamine e whai hua ana ki te whakahaere i te mamae ngawari ki te mamae o muri mai.Heoi ano, ko te tuatahi o tenei momo kaihoko ka tukuna ma te matua hei rongoa rongoa, ka tohuhia mo te werohanga ki roto i te uaua.Ko te Ketorolac he tohu pai ki te rongoa narcotic analgesics na te kore o te mahi kino.Ka whakamahia i te tuatahi mo ona paanga analgesic mo te maimoatanga mo te wa poto o te mamae ngawari ki te ngawari o nga kuri me nga kiore.Ko te roanga o te paanga analgesic i roto i nga kuri e tata ana ki te 8-12 haora, engari na te waatea o nga NSAID kua whakaaetia, he haumaru ake mo nga kuri, he pahekeheke tona whakamahinga.He tote organoammonium i hua mai i te ranunga o te nui equimolar o te ketorolac me te tromethamine (tris).He kaha analgesic kore-sedating analgesic, me te whakaōrite pānga anti-inflammatory.Ka whakamahia mo te wa poto mo te mamae i muri i te mahi, me nga pata o te kanohi hei whakaora i te mamae o te kanohi e pa ana ki te conjunctivitis mate mate.
Nga Tohu Whakamate T - Paitini
Waehere Morearea
R25 - He paitini ki te horomia
R36/37/38 - He whakapataritari ki nga kanohi, te punaha manawa me te kiri.
R23/24/25 - He paitini ma te horomia, ka pa ki te kiri me te horomia.
Whakaahuatanga Haumaru
S26 - Mena ka pa ki nga kanohi, horoi tonu ki te nui o te wai me te rapu tohutohu hauora.
S45 - Ki te aituā, ki te kore koe e pai, rapua he tohutohu hauora (whakaatuhia te tapanga ina taea.)
S36/37/39 - Mau kakahu whakamarumaru tika, karapu me te whakamarumaru kanohi/kanohi.
UN ID UN 2811 6.1/PG 3
WGK Tiamana 3
RTECS UY7759900
Waehere HS 2933995500
Akomanga morearea 6.1(a)
Roopu Tapaki II
Ko te Ketorolac Tromethamine kei roto kaua e iti iho i te 98.5 paiheneti me te kore e neke ake i te 101.5 paiheneti o C15H13NO3·C4H11NO3, kua tatauhia i runga i te tikanga maroke.
Te takai me te rokiroki-Whakaorangia i roto i nga ipu kikii, marama-ātete.Rokiroki i te 25°, ka whakaaetia nga haerenga i waenga i te 15° me te 30°
Paerewa Tohutoro USP <11>-
USP Ketorolac Tromethamine RS
Tautuhinga-
A: Whakangao Infrared <197K>.
B: Te Whakakorikori Ultraviolet <197U>-
Rongoā: 10 µg ia mL
Waenga: mewaro.
C: Whakamātautau Tromethamine-Whakaritea he otinga Paerewa o USP Ketorolac Tromethamine RS i roto i te ranunga o te dichloromethane me te methanol (2:1) kei roto 5 mg ia mL.He rite ano te whakarite i tetahi otinga whakamatautau o te Ketorolac Tromethamine kei roto 5 mg ia mL.Hoatuhia nga pukapuka 40-µL o te wairewa Paerewa me te otinga whakamatautau ki te pereti chromatographic paparanga angiangi (tirohia te Chromatography <621>) kua pania ki te paparanga 0.25-mm o te ranunga chromatographic silica gel.Whakanohoia te pereti ki roto i te ruuma chromatographic i rite i mua ki te ranunga o te dichloromethane, acetone, me te waikawa acetic glacial (95:5:2).Hiahia te rūma, ka whakawhanake i te chromatogram kia nekehia ra ano te mua whakarewa kia toru hauwha o te roa o te pereti.Tangohia te pereti mai i te ruma, ka tuku kia mimiti te whakarewa.Purihia te pereti ki te wairewa waipiro hou kua oti te whakarite he 30 mg ninhydrin ia mL, ka whakamahana i te pereti i te 150° mo te 2 ki te 5 meneti.Ko nga wahi kowhai me nga taitapa mawhero ki te papura ka tipu ki runga i te pereti i nga waahi i tukuna te otinga Paerewa me te otinga whakamatautau.
pH <791>: i waenganui i te 5.7 me te 6.7, i roto i te otinga (1 i roto i te 100).
Ngaronga i runga i te whakamaroke <731>-Me whakamaroke ki te korehau i te 60° mo te 3 haora: kaua e ngaro ake i te 0.5% o tona taumaha.
Te toenga i runga i te mura <281>: kaua e neke ake i te 0.1%.
Nga konganuku taumaha, Tikanga II <231>: 0.002%.
Pure Chromatographic-
Wāhanga pūkoro, Whakaranu whakarewa, Whakarite Paerewa, Whakatau Whakatau, me te punaha Chromatographic-Haere tonu i roto i te Whakatairanga.
Whakamātautau otinga-Whakamahia te whakaritenga Assay.
Tikanga-Chromatograph te otinga Whakamātautau kia rite ki te tohutohu mo te Tikanga i roto i te Whakamatau, ka taea e te chromatography te toro atu ki te toru nga wa te wa pupuri o te ketorolac.Inehia nga whakautu o nga tihi katoa.Tātaihia te ōrau o ia poke takitahi i te wahanga o te Ketorolac Tromethamine i tangohia e te tauira:
100rfi (ri / rs)
ko te rfi te take whakautu o ia tihi poke takitahi e pa ana ki tera o te ketorolac;ko ri te whakautu teitei mo ia poke;a ko te rs te tapeke o nga whakautu tihi katoa o nga tihi poke me te tihi ketorolac nui.Ko nga uara rfi he 0.52 mo te ketorolac 1-keto analog, 0.67 mo te ketorolac 1-hydroxy analog, 2.2 mo te tihi poke he wa pupuri o te 0.54 e pa ana ki tera o te ketorolac, me te 0.91 mo te tihi poke i te wa pupuri whanaunga o 0.66.Kaua e neke ake i te 0.1% o te ketorolac 1-keto analog, o te ketorolac 1-hydroxy analog ranei ka kitea;kaua e neke ake i te 0.5% o etahi atu poke ka kitea;me te tapeke o nga poke katoa kaua e neke ake i te 1.0%.
whakamātautau-
Wāhanga pūkoro-Tarekahia te 5.75 g o te haukinia phosphate monobasic ki te 1000 mL wai, ka whakatika ki te waikawa phosphoric ki te pH o 3.0.Whakapaia he ranunga kua tātarihia, kua whakakorehia te hau o tenei otinga parepare me te tetrahydrofuran (70:30).Whakaritea nga whakarereketanga mehemea e tika ana (tirohia te Tikanga Pūnaha i raro i te Chromatography <621>) ki te whakatutuki i te wa pupuri mo te ketorolac mo te 8 ki te 12 meneti.
Te ranunga whakarewa-Whakaritea he ranunga o te wai me te tetrahydrofuran (70:30).
Whakaritenga Paerewa-Whakarewa i te rahinga tika o te USP Ketorolac Tromethamine RS i roto i te ranunga whakarewa kia whiwhi ai i tetahi otinga e mohiotia ana he 0.4 mg ia mL.[MATUA-Tiakihia tenei otinga mai i te marama.]
Te whakarite whakamatautau-Whakawhitihia te 20 mg o te Ketorolac Tromethamine, i tika te pauna, ki te 50-mL ipu pukapuka, waimeha ki te ranunga whakarewa ki te rōrahi, ka uru.[MATUA-Tiakihia tenei otinga mai i te marama.]
Wairewa Whakatau-I roto i te 250-mL whakawehe i te 100 mL o te wai, 100 mL o te dichloromethane, 30 mg o USP Ketorolac Tromethamine RS, me te 1 mL o te 1 N waikawa pūhaumāota.Kōkuhutia te tūpono, ruru, ka tuku kia wehe ngā paparanga.Whakawhitihia te paparanga dichloromethane o raro ki te ipu karaihe borosilicate kua tutakina, ka makahia te paparanga o runga.Whakaorangia te wairewa dichloromethane ki te ra tika mo te 10 ki te 15 meneti.Whakawhitihia te 1.0 mL o te wairewa ki roto i te ipu, whakaeto i roto i te ia o te hau, i roto ranei i te awa hauota ki te maroke, tāpirihia te 1.0 mL o te ranunga Solvent, ka porohurihia kia memeha.[FAKATOKANGA-Ka taea te rongoa i tenei otinga i raro i te pouaka whakamahana ka whakamahia mena ka tika te chromatogram i whiwhi i runga i te tikanga mo te Tikanga mo te tautuhi i nga tihi na te ketorolac 1-keto analog me te ketorolac 1-hydroxy analog, me te inenga o te taumira. i waenganui i te ketorolac 1-keto analog me te ketorolac.]
Pūnaha Chromatographic (tirohia Chromatography <621>)—Ko te chromatograph wai he mea whakakakahu ki te 313-nm kaitahuri me te 4.6-mm × 25-cm tīwae kei roto te 5-µm kikī L7 me te pupuri tonu i te mahana tonu o te 40°.Ko te tere rere he 1.5 mL ia meneti.Chromatograph the Resolution solution, and record the peak responses as directed for Procedure: the relatives retention times are about 0.63 mo te ketoroac 1-hydroxy analog, 0.89 mo te ketorolac 1-keto analog, me te 1.0 mo te ketorolac;me te taumira, R, i waenga i te ketorolac 1-keto analog me te ketorolac kaua e iti iho i te 1.5.Chromatograph te Whakariterite Paerewa, ka tuhi i nga whakautu teitei i runga i te tohutohu mo te Tikanga: kaua e iti iho te pai o te pou i te 5500 pereti ariā;a ko te inenga paerewa mo nga werohanga tukurua kaua e neke ake i te 1.5%.
Tikanga-Tukuhia wehe nga pukapuka rite (e tata ana ki te 10 µL) o te whakaritenga Paerewa me te whakaritenga Whakatau ki te chromatograph, tuhia nga chromatograms, me te ine i nga whakautu mo nga tihi nui.Tātaihia te rahinga, i te mg, o C15H13NO3·C4H11NO3 i te wahanga o te Ketorolac Tromethamine i tangohia e te tauira:
50C(rU / rS)
i roto i te C ko te kukū, i roto i te mg ia mL, o USP Ketorolac Tromethamine RS i roto i te whakaritenga Paerewa;a ko rU me rS nga urupare tihi ketorolac i whiwhi mai i te whakaritenga Assay me te whakaritenga Paerewa, ia.
