Lasofoxifene Tartrate CAS 190791-29-8 Chiral Purity ≥99.0% Purity ≥98.0% (HPLC) API High Purity
Ko te Kaihanga Kaihanga me te Maama me te Kounga Pumau
Ingoa matū: Lasofoxifene Tartrate
CAS: 190791-29-8
Lasofoxifene Tartrate (CAS: 190791-29-8) i roto i te maimoatanga o Postmenopausal Osteoporosis
Ingoa matū | Lasofoxifene Tartrate |
Nga kupu taurite | (5R,6S)-5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2-naphthalenol Tartrate Oporia |
Tau CAS | 190791-29-8 |
Tau CAT | RF-API20 |
Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
Tātai rāpoi | C28H31NO2.ClH |
Taumaha rāpoi | 450.019 |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura-White |
makuku (KF) | ≤0.50% |
Nga Korewa Taamaha | ≤20ppm |
Chiral Pure | ≥99.0% |
Te Maama / Tikanga Tatauria | ≥98.0% (HPLC) |
Ngaronga i te whakamaroke | ≤0.50% |
Te toenga i runga i te mura | ≤0.50% |
Paerewa Whakamatau | Hainamana Pharmacopoeia (CP);Paerewa hinonga |
Whakamahinga | Mahinga Rongoa Hohe (API);Osteoporosis i muri i te menopause |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko Shanghai Ruifu Chemical Co., Ltd. te kaihanga matua me te kaiwhakarato o Lasofoxifene Tartrate (CAS: 190791-29-8) me te kounga teitei.
Ko te Lasofoxifene Tartrate he tuatoru-whakatupuranga, kore-steroidal selective estrogen receptor modulator (SERM).Ka herea maataki ki te ERalpha tangata me te uara IC50 o te 1.5 nM me te aukati i te mate wheua i roto i nga kiore ovariectomized.I roto i nga rangahau haumanu mo te osteoporosis postmenopausal, ko te 0.5 mg / ra lasofoxifene i hono ki te whakaheke i nga tupono o nga pakaru kore-vertebral me te vertebral, te mate pukupuku ER-positive, te mate ngakau coronary, me te whiu engari he nui ake te mate o nga kaupapa thromboembolic vena.Kua whakaatuhia hoki te Lasofoxifene ki te mahi hei agonist inverse i te CB2 cannabinoid receptor, e tohu ana i tona kaha ki te whakahoki ano hei rongoa mo nga tohu kei a CB2 te whaainga.