LCZ696 Intermediate CAS 1426129-50-1 Purity ≥98.0% (HPLC) ee ≥99.0% Factory High Purity
Taonga Tauhokohoko LCZ696 (CAS: 936623-90-4) Kaiwaenga e Pa ana:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-etil 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (te tote hemicicalcium) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Te ranunga Sacubitril me Valsartan CAS: 936623-90-4
| Ingoa matū | (R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate |
| Nga kupu taurite | LCZ696 Takawaenga |
| Tau CAS | 1426129-50-1 |
| Tau CAT | RF-PI169 |
| Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
| Tātai rāpoi | C20H25NO3 |
| Taumaha rāpoi | 327.42 |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Ma ki te Paura-White |
| Te Maama / Tikanga Tatauria | ≥98.0% (HPLC) |
| Te taikaha Enantiomeric | ee: ≥99.0% |
| makuku (KF) | ≤1.0% |
| Nga Taonga Paa A | ≤1.0% (RRT=0.5) A=(R)-3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Nga Taonga Paa B | ≤1.0% (RRT=0.85) B=Triphenylphosphine oxide |
| Ētahi atu matū | ≤1.0% |
| Nga poke katoa | ≤2.0% |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Takawaenga o LCZ696 (CAS: 936623-90-4) i te maimoatanga o te HFrEF |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Kaihanga me te Pure Nui me te Kounga Pumau
Taonga Tauhokohoko LCZ696 (CAS: 936623-90-4) Kaiwaenga e Pa ana:
(R)-tert-Butyl (1-([1,1-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate CAS: 1426129-50-1
(R,E)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S)-5-(1,1'-biphenyl-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S)-etil 5-(1,1'-biphenyl-4-yl)-4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (te tote hemicicalcium) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Te ranunga Sacubitril me Valsartan CAS: 936623-90-4
Ko te LCZ696 he rongoa whakamatautau i hangaia e Novartis Pharmaceutical o te United States mo te maimoatanga o nga turoro me te Haangai Ngakau me te iti o te Hautanga Whakaputa (HFrEF).Ko te ngoikore o te ngakau he mate whakamate.Kare e taea e te ngakau o te manawanui te pupuhi toto ki te tuku i te tinana, ka puta nga tohu o te dyspnea, te ngenge me te mau tonu o te wai, katahi ka piki haere, ka tino pa ki te oranga.Ka taea e te LCZ696 te whakarei ake i te tiaki taiao o te tinana ki te ngoikore o te ngakau, me te whakanui ake i te taumata o nga peptides natriuretic me etahi atu peptides vasoactive endogenous, me te aukati i te punaha renin-angiotensin-aldosterone (RAAS).Kua honoa a LCZ696 me te rongoa rongoa a Novartis (Diovan, ingoa whanui: valsartan) me te rongoa whakamatautau AHU-377.Ka aukati te AHU377 i te tikanga o nga peptide e rua hei whakaheke i te pehanga toto.Ka whakapai ake a Diovan i te vasodilation me te whakaihiihi i te tinana ki te whakaputa i te konutai me te wai.
