Lenvatinib Mesylate CAS 857890-39-2 Assay 98.0~102.0% Factory

Whakaahuatanga Poto:

Ingoa matū: Lenvatinib Mesylate

CAS: 857890-39-2

Whakamātautau: 98.0~102.0%

Te ahua: Ma ki te Paura-White Paura, Tioata ranei

Whakapā: Takuta Alvin Huang

Pūkoro/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ruifu Chemical Supply Lenvatinib Mesylate Intermediates With High Pure
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5-(Methoxymethylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4

Ngā Āhuatanga matū:

Ingoa matū	Lenvatinib Mesylate
Nga kupu taurite	4-[3-Chloro-4-[(cyclopropylaminocarbonyl)amino]phenoxy]-7-Methoxy-6-Quinolinecarboxamide Mesylate;E 7080 Mesylate;Lenvima
Tau CAS	857890-39-2
Tau CAT	RF-PI1975
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C21H19N4O4Cl.CH4O3S
Taumaha rāpoi	522.96
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Ma ki te Paura-White Paura, Tioata ranei
Tautuhinga	Na IR;Na UV;Na HPLC
Wairewa	He iti te whakarewa ki te wai, karekau i te wairewa
Iwi Whakarewa	228.0~230.0 ℃
Ihirangi wai (KF)	<1.00%
Te toenga i runga i te mura	<0.10%
Nga Korewa Taamaha	<20ppm
Nga Taonga Paanga
Tetahi poke kotahi	<0.50%
Nga poke katoa	<1.00%
Tikanga Whakamatau / Tatau	98.0~102.0% (HPLC Taketake ki te whakamaroke)
Kiato Nui	0.40gm/ml~0.60gm/ml
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	API

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

Painga:

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Taupānga:

Ko te Lenvatinib Mesylate (CAS: 857890-39-2) he aukati-waha me te maha o te aukati o VEGFR1-3, FGFR1-4, PDGFR, KIT, me RET, me nga mahi antitumor kaha.Ko te Lenvatinib Mesylate he kaikawe tyrosine kinase (RTK) te aukati e whai tohu mo te VEGFR2.E whakaatu ana i te mahi antineoplastic, a kua tohuhia mo te maimoatanga o nga turoro e mau ana i te rohe, i te metastatic ranei, te ahu whakamua, te iodine radioactive (RAI)-refractory mate pukupuku thyroid differentiated.Lenvatinib Mesylate i whakaaetia tuatahi e te US Food and Drug Administration (FDA) i te Feb 13, 2015, ka whakaaetia e Pharmaceuticals and Medical Devices Agency o Japan (PMDA) i te Maehe 26, 2015, ka whakaaetia e te European Medicine Agency (EMA) i runga Mei 28, 2015. I whakawhanakehia me te hokohoko hei Lenvima® na Eisai.Ko te Lenvatinib Mesylate he kaitaunati tyrosine kinase kaikawe-a-waha me te aratau herea motuhake e aukati ana i nga mahi kinase o nga kaiwhakawhiwhi o te tauwehe endothelial endothelial (VEGF), hei taapiri atu ki etahi atu kinases tyrosine e pa ana ki te ara proangiogenic me te oncogenic e whakaarohia ana ka uru ki te tipu o te pukupuku. .E tohuhia ana mo te maimoatanga o te mate pukupuku taikaro rereke radioiodine-refractory.Lenvimaka whakamahia e ia ano ki te rongoa i te mate pukupuku thyroid rerekee (DTC), he momo mate pukupuku taikaro e kore e taea te rongoa ki te iodine radioactive me te ahu whakamua.Ka whakamahia te LENVIMA me tetahi atu rongoa e kiia nei ko te everolimus ki te rongoa i nga pakeke he momo mate pukupuku whatukuhu e kiia nei ko te mate pukupuku o te mate pukupuku renal (RCC) i muri i tetahi maimoatanga me tetahi atu rongoa mate pukupuku.