Lenvatinib Mesylate Intermediate CAS 205448-65-3 Purity >98.0% (HPLC) Factory

Whakaahuatanga Poto:

Ingoa matū: Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate

CAS: 205448-65-3

Maamaa: >98.0% (HPLC)

Te ahua: Paura-White ki te Paura Kowhai

Takawaenga o Lenvatinib Mesylate CAS 857890-39-2

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ruifu Chemical Supply Lenvatinib Mesylate Intermediates With High Pure
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5-(Methoxymethylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4

Nga Ahuatanga matū:

Ingoa matū	Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate
Nga kupu taurite	1,4-Dihydro-7-Methoxy-4-Oxo-6-Quinolinecarboxylic Acid Methyl Ester;7-Methoxy-4-Oxo-1,4-Dihydro-Quinoline-6-Carboxylic Acid Methyl Ester;Lenvatinib Intermediate 3
Tau CAS	205448-65-3
Tau CAT	RF-PI1973
Tūnga Taonga	I roto i te Raarangi, Whakaputa Raahanga 50 MT / Tau
Tātai rāpoi	C12H11NO4
Taumaha rāpoi	233.22
Kohuatanga	421.0±45.0℃
Kiato	1.267±0.060 g/cm3
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Paura-White ki te Paura Kowhai
Te Maama / Tikanga Tatauria	>98.0% (HPLC)
Ngaronga i te whakamaroke	<1.00%
Te toenga i runga i te mura	<0.50%
Nga poke katoa	<2.00%
H-NMR	He rite ki te Hanganga
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Takawaenga Rongoa

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

Painga:

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Taupānga:

Ko te Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate (CAS: 205448-65-3) he takawaenga o Lenvatinib Mesylate (CAS: 857890-39-2).Ko Lenvatinib, i hokona i raro i te ingoa waitohu Lenvima i roto i etahi atu, he rongoa mo te mate pukupuku mo te maimoatanga o etahi momo mate pukupuku thyroid me etahi atu mate pukupuku ano hoki.I whakawhanakehia e Eisai Co. me te mahi hei aukati kinase maha ki nga kinase VEGFR1, VEGFR2 me VEGFR3.Kua whakaaetia a Lenvatinib (mai i te tau 2015) mo te maimoatanga o te mate pukupuku thyroid rerekee kei te takiwa o te rohe, te metastatic ranei, te ahu whakamua, me te kore e aro ki te maimoatanga me te iodine radioactive (radioiodine).I te marama o Haratua 2016, i whakaaetia e te US Food and Drug Administration (FDA) (i te whakakotahitanga me te everolimus) mo te maimoatanga o te mate pukupuku o te tinana o te renal cell i muri i tetahi o mua o te rongoa anti-angiogenic.Ka whakaaetia ano te rongoa i roto i te US me te Kotahitanga o Europi mo te mate pukupuku hepatocellular e kore e taea te tango ma te pokanga i nga turoro kaore ano kia whiwhi rongoa mate pukupuku ma te waha, ma te werohia ranei.