Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 Tino Ma
Ko te Kaihanga Kaihanga me te Maama me te Kounga Pumau
Ingoa matū: Lopinavir
CAS: 192725-17-0
He Tino Kaha, Ko te Peptidomimetic HIV-1 Protease Inhibitor
Hua Rangahau e Pa ana ki te COVID-19
API Kounga Teitei, Hanganga Tauhokohoko
Ingoa matū | Lopinavir |
Nga kupu taurite | LPV;ABT-378;Kaletra |
Tau CAS | 192725-17-0 |
Tau CAT | RF-API73 |
Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
Tātai rāpoi | C37H48N4O5 |
Taumaha rāpoi | 628.81 |
Rokiroki mo te wa roa | Rokiroki mo te wa roa ki te 2-8 ℃ |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Ma ki te Paura-White |
Wairewa | Ka Rere noa ki te Mewaro me te Ewaro, Ka Rere ki te 2-Propanol |
Tautuhinga IR | Ko te awhi infrared absorption o te tauira whakamatautau he rite ki te paerewa tohutoro |
Tautuhinga HPLC | Ko te wa pupuri o te tauira whakamatautau ka rite ki tera o te paerewa tohutoro |
Ihirangi Wai (na KF) | ≤4.0% |
Hurihanga Optical Tauwhāiti | -22.0° ki te -26.0° |
Te toenga i runga i te mura | ≤0.20% |
Nga Korewa Taamaha | ≤20ppm |
Iwi Whakarewa | 124.0 ki te 127.0 ℃ |
Te pungarehu whanariki | ≤0.20% |
Wehenga toenga (Ewaro) | ≤0.50% |
Nga Taonga Paanga | (HPLC, Rohe%) |
poke 1 | |
Parakore B (RRT=0.07) | ≤0.20% |
Te poke I (RRT=1.10) | ≤0.20% |
Tetahi atu poke | ≤0.10% |
poke 2 | Tetahi atu poke takitahi ≤0.10% |
Ko nga poke katoa mai i te Tikanga 1 me te 2 | ≤0.70% |
Nga poke katoa | ≤1.0% |
Whakamātautau (na HPLC) | 98.0%~102.0% |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | Tohua Peptidomimetic HIV-1 Protease Inhibitor, Hua Rangahau e Pa ana ki te COVID-19 |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
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Ko te Lopinavir (ABT-378) he tino kaha, he aukati peptidomimetic whiriwhiri o te HIV-1 protease, me te Kis o 1.3 ki te 3.6 pM mo te momo mohoao me te mutant HIV protease.Ka mahi a Lopinavir ma te hopu i te pakeketanga o te HIV-1 ma reira ka aukati i tana mate.Ko Lopinavir ano hoki he aukati SARS-CoV 3CLpro me te IC50 o te 14.2 μM.Ko te Lopinavir he antiretroviral o te karaehe aukati protease.Ko te aukati o te HIV-1 protease ka aukati i te wehenga o te polyprotein viral precursor ka puta te tukunga o nga virion kore-pakeke.He waahanga o te rongoa whakakotahi hei rongoa i te HIV/AIDS.Ko Lopinavir, te tuaono o te HIV protease inhibitor i roto i te karaehe "navir", i whakarewahia i roto i te whakakotahitanga me te ritonavir, tetahi atu aukati HIV protease kua hokona kua hokona (Abbott, 1996);i whakauruhia tenei hanganga taketake hei Kaletra mo te whakamahi i te taha o te nucleoside, te kore-nucleoside reverse transcriptase inhibitors mo te maimoatanga o te AIDS i roto i nga pakeke me nga tamariki.Ko te Lopinavir he puhui peptidomimetic he rite tonu te hanganga ki tera o te ritonavir, i whakaurua mai nga roopu mutunga, ina koa he valine kua whakarereketia e nga tikanga honohono peptide.Ko te Lopinavir he aukati whakataetae kaha mo te HIV-I protease e whakaatu ana i te kaha nui ki te whakarereke i te ritonavir-aukati.I roto i te maha o nga momo kararehe, ko nga rangahau pharmacokinetic me te hononga lopinavirlritonavir i whakaatu ko nga ahuatanga ngawari o te lopinavir i tino pai ake i te aroaro o te ritonavir, mo te Cmax me te roa o te mahi.
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