Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 Tino Pure Whakaaturanga Whakaahua

Lopinavir CAS 192725-17-0 API Anti-HIV HIV Protease Inhibitor COVID-19 Tino Ma

Whakaahuatanga Poto:

Ingoa matū: Lopinavir

CAS: 192725-17-0

Te ahua: Ma ki te Paura Paura Ma

Whakamātautau (HPLC): 98.0%~102.0%

Tohua Peptidomimetic HIV-1 Protease Inhibitor

API Kounga Teitei, Hanganga Tauhokohoko

Inquiry: alvin@ruifuchem.com

Tukuna he imeera ki a matou

Taipitopito Hua

Hua e Pa ana

Tohu Hua

Whakaahuatanga:

Ko te Kaihanga Kaihanga me te Maama me te Kounga Pumau
Ingoa matū: Lopinavir
CAS: 192725-17-0
He Tino Kaha, Ko te Peptidomimetic HIV-1 Protease Inhibitor
Hua Rangahau e Pa ana ki te COVID-19
API Kounga Teitei, Hanganga Tauhokohoko

Ngā Āhuatanga matū:

Ingoa matū	Lopinavir
Nga kupu taurite	LPV;ABT-378;Kaletra
Tau CAS	192725-17-0
Tau CAT	RF-API73
Tūnga Taonga	Kei roto i nga taonga, ka eke ki te rau kirokaramu
Tātai rāpoi	C37H48N4O5
Taumaha rāpoi	628.81
Rokiroki mo te wa roa	Rokiroki mo te wa roa ki te 2-8 ℃
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Ma ki te Paura-White
Wairewa	Ka Rere noa ki te Mewaro me te Ewaro, Ka Rere ki te 2-Propanol
Tautuhinga IR	Ko te awhi infrared absorption o te tauira whakamatautau he rite ki te paerewa tohutoro
Tautuhinga HPLC	Ko te wa pupuri o te tauira whakamatautau ka rite ki tera o te paerewa tohutoro
Ihirangi Wai (na KF)	≤4.0%
Hurihanga Optical Tauwhāiti	-22.0° ki te -26.0°
Te toenga i runga i te mura	≤0.20%
Nga Korewa Taamaha	≤20ppm
Iwi Whakarewa	124.0 ki te 127.0 ℃
Te pungarehu whanariki	≤0.20%
Wehenga toenga (Ewaro)	≤0.50%
Nga Taonga Paanga	(HPLC, Rohe%)
poke 1
Parakore B (RRT=0.07)	≤0.20%
Te poke I (RRT=1.10)	≤0.20%
Tetahi atu poke	≤0.10%
poke 2	Tetahi atu poke takitahi ≤0.10%
Ko nga poke katoa mai i te Tikanga 1 me te 2	≤0.70%
Nga poke katoa	≤1.0%
Whakamātautau (na HPLC)	98.0%~102.0%
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Tohua Peptidomimetic HIV-1 Protease Inhibitor, Hua Rangahau e Pa ana ki te COVID-19

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.

Painga:

FAQ:

Taupānga:

Ko te Lopinavir (ABT-378) he tino kaha, he aukati peptidomimetic whiriwhiri o te HIV-1 protease, me te Kis o 1.3 ki te 3.6 pM mo te momo mohoao me te mutant HIV protease.Ka mahi a Lopinavir ma te hopu i te pakeketanga o te HIV-1 ma reira ka aukati i tana mate.Ko Lopinavir ano hoki he aukati SARS-CoV 3CLpro me te IC50 o te 14.2 μM.Ko te Lopinavir he antiretroviral o te karaehe aukati protease.Ko te aukati o te HIV-1 protease ka aukati i te wehenga o te polyprotein viral precursor ka puta te tukunga o nga virion kore-pakeke.He waahanga o te rongoa whakakotahi hei rongoa i te HIV/AIDS.Ko Lopinavir, te tuaono o te HIV protease inhibitor i roto i te karaehe "navir", i whakarewahia i roto i te whakakotahitanga me te ritonavir, tetahi atu aukati HIV protease kua hokona kua hokona (Abbott, 1996);i whakauruhia tenei hanganga taketake hei Kaletra mo te whakamahi i te taha o te nucleoside, te kore-nucleoside reverse transcriptase inhibitors mo te maimoatanga o te AIDS i roto i nga pakeke me nga tamariki.Ko te Lopinavir he puhui peptidomimetic he rite tonu te hanganga ki tera o te ritonavir, i whakaurua mai nga roopu mutunga, ina koa he valine kua whakarereketia e nga tikanga honohono peptide.Ko te Lopinavir he aukati whakataetae kaha mo te HIV-I protease e whakaatu ana i te kaha nui ki te whakarereke i te ritonavir-aukati.I roto i te maha o nga momo kararehe, ko nga rangahau pharmacokinetic me te hononga lopinavirlritonavir i whakaatu ko nga ahuatanga ngawari o te lopinavir i tino pai ake i te aroaro o te ritonavir, mo te Cmax me te roa o te mahi.