Losartan pāhare pāporo CAS 124750-99-8 API wheketere antihypertensive parakore teitei
Whakaratohia te Losartan Potassium me nga Takawaenga Paatahi me te Kounga Kairangi
Losartan pāhare pāporo CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Ingoa matū | Losartan pāhare pāporo |
| Nga kupu taurite | DuP 753;Cozaar;2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl]imidazole-5-methanol Potassium Tote |
| Tau CAS | 124750-99-8 |
| Tau CAT | RF-API98 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C22H22ClKN6O |
| Taumaha rāpoi | 461.01 |
| Iwi Whakarewa | 263.0~265.0℃ |
| Wairewa | Ka Rere noa ki te Wai me te Mewaro, Ka Rere Ki Te Acetonitrile. |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Paura ma, tata ma ranei te kirikiriata |
| Tautuhi A | Te Kohanga Infrared: Me rite ki te Paerewa Tohutoro |
| Tautuhinga B | Ultraviolet absorption: Me rite ki te Paerewa Tohutoro |
| Te whakamatautau mo te konupora | Me pai |
| Ihirangi wai (KF) | ≤0.50% |
| Nga Korewa Taamaha | ≤10ppm |
| Matū Paatahi (HPLC) | |
| Te poke takitahi | ≤0.20% |
| Nga poke katoa | ≤0.50% |
| Wairewa Toenga (GC) | |
| Cyclohexane | ≤0.10% |
| Waipiro Isopropyl | ≤0.20% |
| Tikanga Whakamātautau/Atatari | 98.5~101.0% (HPLC, tatau i runga i te waikore, te whakarewa-kore) |
| N-Nitrosodiethylamine | ≤0.177ppm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Rahi Matūriki | 90% Iti iho i te 38 Microns |
| Te Ora Papa | 24 Marama |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | API, Angiotensin II Receptor Antagonist Antihypertensive |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko te Losartan Potassium te tuatahi o te kaha me te kowhiringa kore-peptide angiotensin II receptor momo 1 (AT1) antagonist i whakauruhia ki te maakete hei antihypertensive waha kotahi-ra.Ko te kukū e aukati ana i te 50% o te herenga o te angiotensin II (IC50) he 20 nM.Ko Losartan (40 μM) ka pa ki te ISC engari ka aukati i te paanga o te ANGII ki te ISC.Ka tino whakaitihia e Losartan te pikinga o te Ang II-mediated cell cell in cell cancer endometrial.Ko te whakakotahitanga o te losartan me te anti-miR-155 he tino nui ake te paanga antiproliferative ki ia raau taero anake.Ka whakakorikoria ki te whakaputa i te 5-carboxylic acid metabolite (EXP3174) me te korero ki te whakaheke toto toto.I tenei wa kei te rangahauhia hei rongoa mo COVID-19 mo tona kaha ki te whakaiti, ki te whakaiti ranei i nga tohu o COVID-19.
1. Mo te maimoatanga o te takawhita tino nui, ka taea te whakamahi takitahi, me te whakakotahi ranei me etahi atu raau taero antihypertensive (pērā i te diuretics).2. Mo te maimoatanga o te ngoikore o te ngakau, ka taea te whakamahi mo ia anake, me te whakakotahi ranei me nga raau taero Cardiotonic, diuretic Chemicalbook ranei.3. Te aukati i te whiu i roto i nga turoro me te whakaheke toto me te hypertrophy ventricular maui.4. Ka whakamahia hei whakaroa i te haere o te nephropathy i nga turoro me te mate huka momo 2 e pa ana ki te nephropathy me te whakaheke toto.
