Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8 Purity >98.0% (GC) Lenvatinib Mesylate Intermediate Factory

Whakaahuatanga Poto:

Ingoa matū: Methyl 4-Amino-2-Methoxybenzoate

CAS: 27492-84-8

Parakore: >98.0% (GC)

Te ahua: Ma ki te Paura-White Paura, Tioata ranei

Takawaenga o Lenvatinib Mesylate CAS 857890-39-2

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ruifu Chemical Supply Lenvatinib Mesylate Intermediates With High Pure
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1-(2-Chloro-4-Hydroxyphenyl)-3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5-(Methoxymethylene)-2,2-Dimethyl-1,3-Dioxane-4,6-Dione CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4

Nga Ahuatanga matū:

Ingoa matū	Methyl 4-Amino-2-Methoxybenzoate
Nga kupu taurite	4-Amino-2-Methoxybenzoic Acid Methyl Ester;Methyl 4-Amino-o-Anisate;4-Amino-o-Anisic Acid Methyl Ester
Tau CAS	27492-84-8
Tau CAT	RF-PI1974
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C9H11NO3
Taumaha rāpoi	181.19
Kiato	1.179±0.060 g/cm3
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Ma ki te Paura-White Paura, Tioata ranei
Te Maama / Tikanga Tatauria	>98.0% (GC)
Te Maama / Tikanga Tatauria	97.5~102.5 (Titaretanga Kore)
Te Whakarewa	157.0~161.0℃
Ngaronga i te whakamaroke	<1.00%
Nga poke katoa	<2.0%
Spectrum Infrared	He rite ki te Hanganga
Proton NMR Spectrum	He rite ki te Hanganga
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Takawaenga o Lenvatinib Mesylate (CAS: 857890-39-2)

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

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Taupānga:

Methyl 4-Amino-2-Methoxybenzoate (CAS: 27492-84-8) ka taea te whakamahi hei takawaenga o Lenvatinib Mesylate (CAS: 857890-39-2).Ko Lenvatinib he rongoa mate pukupuku thyroid i whakawhanakehia e Eisai Corporation o Hapani (Waehere: E7080), no roto i te aukati o te waha maha-receptor tyrosine kinase (RTK) ka taea te aukati i te mahi kinase o te vascular endothelial growth factor (VEGF) Receptors VEGFR1 ( FLT1), VEGFR2 (KDR), me VEGFR3 (FLT4).Ka taea hoki e Lenvatinib te whakakore i te whakauru o etahi atu RTK i roto i te angiogenesis pathological, te tipu o te pukupuku, me te haere o te mate pukupuku engari mo o raatau mahi pūtau noa tae atu ki te fibroblast growth factor (FGF) nga kaiwhiwhi FGFR1, 2, 3, me te 4;te kaikawe tauwehe tipu i ahu mai i te platelet (PDGFR [alpha]), KIT, me te RET.[Nga Tohu]: He pai a Lenvatinib mo te maimoatanga o nga turoro o te mate pukupuku taikaro o te hokinga mai o te rohe, te momo metastasis ranei, te momo ahunga whakamua me te momo rerekee o te iodine-refractory radioactive.I te Hui-tanguru 13, 2015, i whakaaetia e te US FDA te tarukino anticancer Lenvatinib mo te maimoatanga o te mate pukupuku thyroid.Ko te Lenvatinib he aukati maha-whaanui-a-whaanui, he kaha ki te aukati i te VEGFR2 me te VEGFR3 (te kaikawe tauwehe endothelial vascular).Ko te ingoa hokohoko o Lenvatinib ko Lenvima.I te Haratua 20, 2015, i whakaaetia e te European Medicines Agency (EMA) a Lenvatinib mo te maimoatanga o te mate urutomo, te matatau o te rohe, te metastatic rereke ranei (papillary, follicular, Hurthle momo) mate pukupuku thyroid (DTC).I roto i te whakamatautauranga, ko te wa roa mo te oranga mo nga turoro o te DTC radioactive iodine-refractory DTC i tukuna ki a Lenvatinib he 18 marama ko te uara mo nga turoro e tango placebo he 3 marama anake.