Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8 PF-07321332 Boceprevir Intermediate

Whakaahuatanga Poto:

Ingoa matū: Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate

CAS: 328086-60-8

Te ahua: Ma ki te Paura-White

Takawaenga o PF-07321332 Paxlovid (CAS 2628280-40-8) me Boceprevir (CAS 394730-60-0)

Kounga Teitei, Hanganga Aromoni

Inquiry: alvin@ruifuchem.com

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Hua e Pa ana

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Whakaahuatanga:

Whakarato Aromoni PF-07321332 Paxlovid Takawaenga e Pa ana ki te Kounga teitei
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(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-Carboxylic Acid Methyl Ester Hydrochloride 565456-77-1
Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate CAS 328086-60-8
6,6-Dimethyl-3-azabicyclo[3.1.0]hexane CAS 943516-54-9

Ngā Āhuatanga matū:

Ingoa matū	Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate
Nga kupu taurite	Methyl (S)-2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate;(αS,3S)-α-[(tert-Butyloxycarbonyl)aMino]-2-oxo-3-pyrrolidinepropanoic acid Methyl Ester;(S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate
Tau CAS	328086-60-8
Tau CAT	RF-PI317
Tūnga Taonga	Kei roto i nga taonga, ka eke ki te rau kirokaramu
Tātai rāpoi	C13H22N2O5
Taumaha rāpoi	286.33
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Ma ki te Paura-White
Tautuhi A	IR: He rite ki te Matū Tohutoro
Tautuhinga B	Wā Pupuri: He rite ki te Matū Tohutoro
Ngaronga i te whakamaroke	≤1.0%
Te toenga i runga i te mura	≤0.20%
Te poke kotahi	≤0.50%
Nga poke katoa	≤2.0%
Konga Taamaha (Pb)	≤20ppm
Maamaa	≥98.0%
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Takawaenga o PF-07321332 Paxlovid (CAS 2628280-40-8) me Boceprevir (CAS 394730-60-0)

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.

Painga:

FAQ:

Taupānga:

Ko te Methyl (S)-2-(Boc-amino)-3-[(S)-2-oxo-3-pyrrolidinyl]propanoate (CAS 328086-60-8) te takawaenga o PF-07321332 Paxlovid (CAS 2628280-40 -8) me Boceprevir (CAS 394730-60-0).Ko te PF-07321332, te waahanga matua o Paxlovid (PF-07321332 me Ritonavir) he kaitono antiviral a-waha COVID-19, he aukati 3C-rite te protease (3CLPRO) e waatea ana ki te waha me nga paanga antiviral kaha ki te huaketo SARS-CoV-2 me COVID-19.I te Nove 6th 2021, i kii a Pfizer i tino whakahekehia e Paxlovid te hohipera me te mate, i runga i te tātaritanga o te Wāhanga 2/3 EPIC-HR (Te Aromatawai mo te aukati Protease mo te COVID-19 i roto i nga Turoro Nui-Risk) matapōkeretia, rangahau matapo-rua. o nga turoro pakeke kore i te hōhipera me COVID-19, he nui te tupono ki te ahu whakamua ki te mate kino.Ko te Boceprevir (EBP-520) he aukati protease HCV (Ki=14 nM) mo te maimoatanga o te mate huaketo kakā C.Ko te Boceprevir me te pegylated interferon me te ribavirin (PegIFN/RBV) i taea te whakapai ake i nga reiti whakautu virological toitū o nga turoro me te momo momo 1 HCV.Ka taunekeneke a Boceprevir me te rongoa immunosuppressive (IT) ma te aukati i te enzyme cytochrome P450 3A.