N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Purity >99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Whakaahuatanga Poto:

Ingoa matū: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Maamaa: >99.0% (HPLC)

Te ahua: Kowhai Maama ki te Paura Kowhai

Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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Whakaahuatanga:

Ruifu Chemical Supply Takawaenga o Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino)acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Waikawa Diethylphosphonoacetic CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-kotahi CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineCAS 314771-88-5

Ngā Āhuatanga matū:

Ingoa matū	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Nga kupu taurite	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl)(7-Fluoro-6-Nitroquinazolin-4-yl)amine;4-(3-Chloro-4-Fluoroanilino)-7-Fluoro-6-Nitroquinazoline;Afatinib Intermediate A
Tau CAS	162012-67-1
Tau CAT	RF-PI2026
Tūnga Taonga	I roto i te Stock, Production Tauine Up ki Taranata
Tātai rāpoi	C14H7ClF2N4O2
Taumaha rāpoi	336.68
Te tairongo	Te Hau, Te wera
Iwi Whakarewa	242.0~244.0℃
Kohuatanga	489℃
Kiato	1.616
Waitohu	Ruifu Chemical

Whakatakotoranga:

Tūemi	Whakatakotoranga
Te ahua	Kowhai Maama ki te Paura Kowhai
Te Maama / Tikanga Tatauria	>99.0% (HPLC)
Ngaronga i te whakamaroke	<0.50%
Te toenga i runga i te mura	<0.20%
Nga Taonga Paanga
Te poke takitahi	<0.50%
Nga poke katoa	<1.00%
Nga Korewa Taamaha	≤20ppm
Spectrum Infrared	He rite ki te Hanganga
Proton NMR Spectrum	He rite ki te Hanganga
Paerewa Whakamatau	Paerewa hinonga
Whakamahinga	Takawaenga o Afatinib Dimaleate (CAS: 850140-73-7)

Mōkī me te Rokiroki:

Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko

Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku

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Taupānga:

N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) he takawaenga i roto i te whakahiato o Afatinib Dimaleate (CAS: 850140-73-7) .Ko te Afatinib Dimaleate he ahua tote o Afatinib.Ko te Afatinib he reanga tuarua, he mea whakahaere-waha, he aukati korekore o te whanau ErbB o tyrosine kinases.Mechanism of ActionAfatinib downregulates ErbB signing by covalently binding to the kinase domains of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor (HER) 2 and HER4, ka hua mai i te aukati korekore o te tyrosine kinase autophosphorylation;ka aukati hoki i te transphosphorylation o HER3.Kua whakaaetia a Afatinib hei monotherapy mo te maimoatanga o te EGFR tyrosine kinase inhibitor (TKI) -pakeke korekore ki te rohe matatau ranei DefinitionChEBI: He tote maleate i whiwhi ma te whakakotahi i te afatinib me nga momo molar e rua o te waikawa maleic.Ka whakamahia mo te maimoatanga raina-tuatahi o nga turoro me te mate pukupuku pukupuku pūtau kore-iti.