N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC Kounga teitei
Whakarato me te Maama me te Kounga Pumau
Ingoa matū: N(4)-Hydroxycytidine;EIDD-1931 (NHC)
CAS: 3258-02-4
He metabolite kaha o Molnupiravir, he aukati COVID-19
| Ingoa matū | N(4)-Hydroxycytidine |
| Nga kupu taurite | EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| Tau CAS | 3258-02-4 |
| Tau CAT | RF-PI309 |
| Tūnga Taonga | Kei roto i nga taonga, te Tauine Whakaputa ki te Kirokararama |
| Tātai rāpoi | C9H13N3O6 |
| Taumaha rāpoi | 259.22 |
| Iwi Whakarewa | 169.0~172.0 ℃ |
| Wairewa | Wairewa ki te 100 mM ki DMSO me ki te 50 mM ki te wai |
| Kiato | 1.93±0.1 g/cm3 |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Ma ki te Paura-White |
| NMR | E rite ana ki te Hanganga |
| Te Maama / Tikanga Tatauria | >98% (HPLC) |
| Ngaronga i te whakamaroke | ≤1.0% |
| Te poke kotahi | ≤0.50% |
| Nga Korewa Taamaha | ≤20ppm |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | He metabolite kaha o Molnupiravir (EIDD-2801), he aukati COVID-19 |
Mōkī: Pounamu, Peeke konumohe konumohe, Pahu Kaata, 25kg / Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Whakaorangia mai i te marama, te makuku me te mate kino.
Ko te N(4)-Hydroxycytidine (EIDD-1931, β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) he metabolite kaha o EIDD-2801, he aukati COVID-19.Ko te EIDD-1931 (NHC) he mahi antiviral whanui ki te maha o nga coronaviruses, tae atu ki te SARS-CoV-2, MERS-CoV, SARS-CoV, me nga roopu zoonotic 2b ranei 2c Bat-CoV me te IC50 toharite o te 0.15 μM, me te kua piki ake te kaha ki te coronavirus e mau ana i nga huringa aukati ki te nucleoside analog inhibitor remdesivir.I nga kiore kua pangia e te SARS-CoV, MERS-CoV ranei, ko te whakahaere prophylactic me te rongoa mo te Molnupiravir (EIDD-2801), he NHC-prodrug (β-D-N4-hydroxycytidine-5'-isopropyl ester), he pai ake te mahi o te pulmonary. , me te whakaheke i te titer huaketo me te mate taimaha o te tinana.Ko te hekenga o nga hua MERS-CoV i roto i te vitro me te in vivo i hono ki te pikinga o te huringa whakawhiti i roto i te viral engari ehara i te RNA pūtau kaihautu, e tautoko ana i te tikanga o te mutagenesis whakamate i roto i te CoV.Ko te kaha o te NHC/EIDD-2801 ki te maha o nga coronaviruses me te koiora-a-waha e whakaatu ana i tana whaipainga hei rongoa patu huaketo whai hua ki te SARS-CoV-2 me etahi atu coronaviruses zoonotic a meake nei.
