Olaparib AZD-2281 CAS 763113-22-0 Purity ≥99.0% API Factory
Te Pure Teitei, Te Hanganga Aromoni
Olaparib me nga Takawaenga Paanga:
Olaparib CAS 763113-22-0
2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)waikawa benzoic CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Ingoa matū | Olaparipi |
| Nga kupu taurite | AZD-2281;KU0059436;Lynparza;4-(3-(4-(cyclopropanecarbonyl)piperazine-1-carbonyl)-4-fluorobenzyl)phthalazin-1(2H)-one;1-(Cyclopropylcarbonyl)-4-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)Methyl]-2-fluorobenzoyl]piperazin |
| Tau CAS | 763113-22-0 |
| Tau CAT | RF-API103 |
| Tūnga Taonga | Kei roto i nga taonga, ka eke ki te rau kirokaramu |
| Tātai rāpoi | C24H23FN4O3 |
| Taumaha rāpoi | 434.46 |
| Wairewa | Wairewa i roto i te DMSO |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Ma ki te Paura-White |
| Te tautuhi na 1H NMR | Kia rite ki te hanganga |
| LC-MS | Kia rite ki te hanganga |
| Te Maama / Tikanga Tatauria | ≥99.0% (na LC-MS) |
| makuku (KF) | ≤0.50% |
| Te poke kotahi | ≤0.50% |
| Nga poke katoa | ≤1.0% |
| Konga Taamaha (hei Pb) | ≤20ppm |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | API;Kaihanga PARP |
Mōkī: Pounamu, Peeke konumohe konumohe, Paera Kaata, 25kg / Paera, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku.
Olaparib (CAS: 763113-22-0), he tino kaha me te whiriwhiri PARP-inhibitor.I te Hakihea 19, 2014, i whakaaetia e te FDA te rongoa rongoa mo te mate pukupuku o Olaparib (Lynparza) mo te whakamaarama kotahi ki nga turoro o te mate pukupuku ovarian teitei kua pa ki te 3 rauna o te chemotherapy, nga turoro ranei kua whakapaehia he rereke BRCA.I taua wa ano, ka whakaaetia e te FDA te inenga me te whakarōpūtanga o nga kete tātari mo te rapunga o nga huringa i roto i te BRCA1 me te BRCA2, BRACAnalysis CDx.Ko Olaparib te rongoa aukati PARP tuatahi kua whakaaetia e te FDA.I te Hui-tanguru 2, 2015, i whakaaetia ano e te European Union Food and Drug Administration (EMA) a Olaparib kia uru atu ki te maakete i nga whenua 28 o te Kotahitanga o Europi tae atu ki Iceland, Liechtenstein me Norway.Engari ko nga tohu o te EMA me te FDA kua whakaaetia he paku rereke;ko te mea o mua mo nga keehi ira ira ira BRCA, me te rongoa hoki mo nga turoro o te mate pukupuku ovarian epithelial matatau kua whiwhi i nga raau taero chemotherapy kei roto i te konukawata me te whakaatu whakautu me te hoki ano.
