Olopatadine Hydrochloride Intermediate CAS 27710-82-3 Purity >99.0% (HPLC)
Kaiwhakarato Matua o Olopatadine Hydrochloride Intermediates
Olopatadine Hydrochloride CAS 140462-76-6
Isoxepac CAS 55453-87-7
[3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide CAS 27710-82-3
Please Contact: alvin@ruifuchem.com
| Ingoa matū | [3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide |
| Nga kupu taurite | (3-Dimethylaminopropyl)triphenylphosphonium Bromide HBr |
| Tau CAS | 27710-82-3 |
| Tau CAT | RF2698 |
| Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
| Tātai rāpoi | C23H28Br2NP |
| Taumaha rāpoi | 509.27 |
| Iwi Whakarewa | 283.0~285.0℃ |
| Te pumau | Hygroscopic |
| Wairewa | Chloroform (Paku), Methanol (Paku) |
| Waitohu | Ruifu Chemical |
| Tūemi | Whakatakotoranga |
| Te ahua | Ma ki te Paura Kiriata-White |
| Te Maama / Tikanga Tatauria | >99.0% (HPLC) |
| Tikanga Whakamatau / Tatau | >99.0% (Titaration) |
| Ngaronga i te whakamaroke | <0.50% |
| Te poke kotahi | <0.50% |
| Nga poke katoa | <1.00% |
| 1 H NMR Spectrum | E rite ana ki te Hanganga |
| Paerewa Whakamatau | Paerewa hinonga |
| Whakamahinga | Takawaenga o Olopatadine Hydrochloride (CAS: 140462-76-6) |
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[3-(Dimethylamino)propyl]triphenylphosphonium Bromide Hydrobromide (CAS: 27710-82-3) he takawaenga o Olopatadine Hydrochloride (CAS: 140462-76-6).Ko te Olopatadine Hydrochloride he rongoa aukati mate mate.E rua nga paanga o te aukati i te tukunga o te histamine me te whakawhanaunga i nga kaiwhakawhiwhi HI, kaore he aukati i te punaha nerve matua me nga paanga paitini o te ngakau e pa ana ki nga raau taero antiallergic antagonist HI.Ko te Olopatadine Hydrochloride e kore e taea te aukati i te tukunga o te histamine mai i nga mast cell, engari ka kaha ake te whakatoi i nga kaiwhakawhiwhi H1, kaore he paanga ki nga kaiwhakawhiwhi α adrenergic, dopamine receptors, me nga kaiwhakawhiwhi M1 me M2.I roto i a raatau, he iti noa nga paanga o te punaha o te pokapū, he whakatipuranga hou o nga raau taero antiallergic e pai ana.Ko te Olopatadine he kaha, he antagonist whiriwhiri o te H1 histamine receptor (Ki = 16-41.1 nM), he iti ake nga hononga mo te H2 me te H3 receptors (Ki = 43.4 me te 172 μM, ia).Ka aukatihia e ia te hurihanga phosphoinositide a histamine-induced i roto i nga ruma taratahi (IC50 = 9.5-39.9 nM) me te aukati i te anaphylaxis cutaneous i roto i te kiore (ED50 = 49 μg/kg) me te bronchoconstriction anaphylactic i roto i nga poaka guinea (ID50 = 30 μg/kg).He pai te Olopatadine ki te rongoa i te rhinitis mate me te conjunctivitis.Ka pehia hoki te patito i roto i nga turoro me te urticaria mau tonu te whakahaere pai.I roto i te tangata, karekau tenei antihistamine e whakararu i te hinengaro, i te hinengaro hinengaro ranei i nga pota rongoa.
