Ondansetron Hydrochloride Dihydrate CAS 103639-04-9 Assay 98.0~102.0%
Ko Shanghai Ruifu Chemical te kaihanga matua o Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9) me te kounga teitei.Ka taea e Ruifu te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona Ondansetron Hydrochloride Dihydrate,Please contact: alvin@ruifuchem.com
Nga Takawaenga e pa ana ki te Ondansetron Hydrochloride Dihydrate
Ingoa matū | Ondansetron Hydrochloride Dihydrate |
Nga kupu taurite | Ondansetron HCl Dihydrate;1,2,3,9-Tetrahydro-9-Methyl-3-[(2-Methyl-1H-imidazol-1-yl)methyl]-4H-Carbazol-4-one Hydrochloride Dihydrate;Emeset;GR 38032 Hydrochloride Dihydrate;SN 307 Hydrochloride Dihydrate;GR 3832 HCl 2H2O;SN-37 HCl 2H2O;NSC665799 HCl 2H2O |
Tūnga Taonga | Kei roto i nga taonga, Tauine Aromoni |
Tau CAS | 103639-04-9 (Dihydrate) |
CAS RN e pa ana | 99614-02-5 (Turanga) & 99614-01-4 (Anhydrous) |
Tātai rāpoi | C18H19N3O·HCl·2H2O |
Taumaha rāpoi | 365.86 g/mol |
Iwi Whakarewa | 176.0 ki te 180.0 ℃ |
Tairongo | Te werawera |
Wairewa wai | Wairewa ki te wai (>5 mg/ml) |
Rokiroki Temp. | Wahi Matao me te maroke (2~8℃) |
COA & MSDS | Kei te waatea |
Waitohu | Ruifu Chemical |
Nga taonga | Nga Paerewa Tirotiro | Hua |
Te ahua | Ma ki te Paura Tioata-White | Ka tutuki |
Tautuhinga | ||
1. UV | Max 209, 248, 267, 310nm | Kua whai tohu |
2. IR tūāwhiorangi | He rite ki te Hanganga | Kua whai tohu |
3. Whakahāweatanga o te Chloride | Tauhohenga Whakamua | Kua whai tohu |
Wai na Karl Fischer | 9.0~10.5% | 9.7% |
Te toenga i runga i te mura | ≤0.10% | 0.03% |
Konga Taamaha (Pb) | ≤10ppm | <10ppm |
Ondansetron Pūhui Pānga C | ≤0.20% | 0.09% |
Ondansetron Pānga pūhui D | ≤0.10% | 0.04% |
Imidazole | ≤0.20% | 0.02% |
2-Methylimidazole | ≤0.20% | 0.02% |
Ondansetron Pānga Puhui A | ≤0.20% | 0.05% |
Ētahi atu poke takitahi Unknown | ≤0.10% | 0.07% |
Nga poke katoa | ≤0.50% | 0.29% |
Wairewa toenga | ||
Ewaro | ≤5000ppm | 240ppm |
Te whakamatautau | 98.0~102.0% (Kua tātaihia i runga i te waikore) | 99.81% |
Whakamutunga | Kua whakamatauria te hua me te whai ki nga whakaritenga |
Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Rokiroki i roto i te ipu kati kati.Rokiroki i roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.
Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.
Nga maakete matua?Hokona ki te maakete kaainga, Amerika Te Tai Tokerau, Uropi, Inia, Korea, Hapani, Ahitereiria, aha atu.
Nga painga?Ko te kounga teitei, te utu utu, nga ratonga ngaio me te tautoko hangarau, te tuku tere.
KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.
Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.
MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.
Wā Tukunga? Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku.
Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.
Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.
Whakaritenga Whakaritenga?Ka taea te whakarato ratonga whakahiato ritenga kia pai ai to hiahia rangahau.
Nga tikanga utu?Ko te nama Proforma ka tukuna tuatahi i muri i te whakapumautanga o te ota, ka kohia o maatau korero peeke.Te utu ma te T/T (Telex Transfer), PayPal, Western Union, etc.
Waehere Morearea
R25 - He paitini ki te horomia
R36/37/38 - He whakapataritari ki nga kanohi, te punaha manawa me te kiri.
Whakaahuatanga Haumaru
S45 - Ki te aituā, ki te kore koe e pai, rapua he tohutohu hauora (whakaatuhia te tapanga ina taea.)
S37/39 - Kia mau nga karapu tika me te whakamarumaru kanohi/kanohi
S26 - Mena ka pa ki nga kanohi, horoi tonu ki te nui o te wai me te rapu tohutohu hauora.
UN ID UN 2811 6.1/PG 3
WGK Tiamana 3
RTECS FE6375500
Waehere HS 29339900
Akomanga morearea 6.1(a)
Roopu Tapaki II
Ko te Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9) he kaitakawaenga kaikawe rerotonin (5-HT3) motuhake.Whakahau.Ka whakamahia te Ondansetron Hydrochloride Dihydrate ki te aukati i te nausea me te ruaki ka puta mai pea i te pokanga, te chemotherapy mate pukupuku, te maimoatanga radiation ranei.Ko nga kaiwhaiwhai 5-HT3 i roto i te Ondansetron ko nga raau taero tuatahi e whakamahia ana ki te rongoa me te aukati i te nausea me te ruaki i puta mai i te chemotherapy-induced nausea me te ruaki, na roto i te aukati i nga mahi a nga matū i roto i te tinana.He pai ake te whaihua i te metoclopramide me te iti ake o te whakamaarama i te cyclizine me te droperidol ranei.Heoi, he iti noa te pa ki te ruaki na te mate nekehanga.Ka taea te hoatu ma te mangai, ma te werohia ki roto i te uaua, ki te uaua ranei.
Ko te Ondansetron me te Granisetron, Dolasetron e toru nga rongoa rongoa e whakamahia ana e te haumanu, ko te ondansetron he kaikawe kaikawe serotonin (5-HT3) ka taea te huri me te whiriwhiri, mo te α1, α2, β1, β2-adrenergic receptors me te histamine H1, H2 receptors. he iti noa te paanga, mo nga kaiwhakawhiwhi H, nga kaiwhakawhiwhi dopaminergic pokapū me te peripheral, kare he antagonistic, ka taea e ia te pehi i te chemotherapy me te radiotherapy-induced nausea me te ruaki.Ki te whakatauritea ki te metoclopramide, he kaha ake tona paanga antiemetic me te kore he tauhohenga extrapyramidal.Mo te ruaki na te cisplatin, te cyclophosphamide, te doxorubicin, me etahi atu ka taea te whakaputa tere me te kaha antiemetic.He pai mo te maimoatanga o te nausea me te ruaki na te cytotoxic chemotherapy me te whakamaarama radiation, engari mo te aukati me te maimoatanga o te nausea me te ruaki i puta mai i nga pokanga.Ka mahi a Ondansetron hei waahi whakawhiti i waenga i te nerve afferent visceral e whakahohehia ana i roto i te waahanga gastrointestinal me te pokapū ruaki i roto i te taurakira, e arahi ana ki nga nekehanga o te diaphragm me nga uaua puku.Ka taea e te whakamaarama me te whakamaarama iraruke te tuku i te 5-HT intestinal me te whakaihiihi i te nerve vagus e te kaiwhakawhiwhi 5-HT3, ka puta te ruaki.Ko tenei hua ka aukati i te ahua o te hurihanga, i te wa ano ka aukati i te ruaki i puta mai i te mahi matua.Ko te tikanga mo te nausea me te ruaki i muri i te mahi kaore i te mohiotia.Ko te Ondansetron me te dexamethasonecan ka taea te whakarei ake i te paanga anti-emetic.
Ko tenei ka puta te rere o te afferent vagal, ka puta te ruaki.I roto i te here ki nga kaiwhakawhiwhi 5-HT3, ka aukati te ondansetron i te whakaongaonga o te serotonin, na reira ka ruaki, i muri i nga whakaoho emetogenic penei i te cisplatin.Ko te mamae o te mahunga te tino korero kino o enei rongoa.
He paihana na roto i te ara whakaroto.Human systemic effects by intravenous route: jaundice.Ina whakamahana ki te pirau, ka puta nga kohu paitini o NOx.
Ka whakamahia hei rongoa i te wa e kore e whai hua nga rongoa rongoa tikanga, penei i te wa e whakahaere ana i te cisplatin, mo etahi atu take o te ruaki kore e taea.Ko te whakamahinga o te ondansetron i roto i nga ngeru he ahua tautohetohe, ko etahi e kii ana kia kaua e whakamahia ki tenei momo.
Whakawhanaungatanga raau taero Ko nga taunekeneke kino pea me etahi atu raau taero.
1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one.
1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one.
otinga paerewa | Dilution | Kukū (µg RS ia mL) | Te ōrau (%, hei whakatairite ki te tauira whakamātautau) |
A | (1 i roto i te 5) | 50 | 0.4 |
B | (1 i roto i te 10) | 25 | 0.2 |
C | (1 i roto i te 20) | 12.5 | 0.1 |
Wairewa Whakamatau-Whakarewahia te rahinga tika o te Ondansetron Hydrochloride ki te methanol kia whiwhi ai i te otinga he 12.5 mg ia mL.Tikanga-Hoatu wehea te 20 µL o te otinga Whakamatau, 20 µL o ia otinga Paerewa, me te 20 µL o te otinga Whakatau ki tetahi pereti chromatographic paparanga angiangi (tirohia te Chromatography621) kua whakakikoruatia ki te paparanga 0.25-mm o te ranunga chromatographic silica gel.Whakawhanakehia te chromatogram i roto i te punaha whakarewa he ranunga o te chloroform, ethyl acetate, methanol, me te ammonium hydroxide (90:50:40:1) tae noa ki te neke o te mua whakarewa ki te toru hauwha o te roa o te pereti.Tangohia te pereti mai i te ruma, tohuhia te whakarewa ki mua, ka tuku kia mimiti te whakarewa.Tirohia te pereti i raro i te rama UV roangaru-poto: ka kitea te otinga o nga wahanga e toru o te waahi otinga Whakatau.Whakatauritea te kaha o nga waahi tuarua ka kitea i roto i te chromatogram o te otinga Whakamatau me era o nga waahi matua i roto i nga chromatograms o nga otinga Paerewa: tetahi waahi tuarua mai i te chromatogram o te otinga Whakamatau he uara RF e rite ana ki tera o te tuarua o runga. ko te waahi o te otinga Whakatau kaore i te nui ake, i te kaha ake ranei i te waahi matua i riro mai i te otinga Paerewa A (0.4%);a kaore he waahi tuarua mai i te chromatogram o te otinga Whakamatau ka nui ake, ka kaha ake ranei i te waahi matua i whiwhi mai i te otinga Paerewa B (0.2%).
ko C te kukū, i te mg ia mL, o te USP Ondansetron Hydrochloride RS i roto i te otinga Paerewa;Ko W te taumaha, i te mg, o Ondansetron Hydrochloride i tangohia hei whakarite i te otinga Whakamatau;Ko te F te tauwehe whakautu o nga poke e whakaahuatia ana i te ripanga e whai ake nei;Ko ri te waahi teitei mo ia poke i roto i te otinga Whakamatau;a ko rS te waahi teitei o te ondansetron i riro mai i te otinga Paerewa: e tutuki ana i nga whakaritenga e homai ana i te ripanga e whai ake nei.
Ingoa Pūhui | Wā Pupuri Whanaunga | Whanaunga Whakautu Tauwehe | Tepe (%) |
---|---|---|---|
Ondansetron pūhui hono C | āhua 0.32 | 1.2 | 0.2 |
Ondansetron pūhui hono D* | tata ki te 0.34 | — | 0.1 |
Imidazole | tata ki te 0.49 | 0.3 | 0.2 |
2-methylimidazole | tata ki te 0.54 | 0.4 | 0.2 |
Ondansetron | 1.0 | — | — |
Ondansetron pūhui hono A | āhua 1.10 | 0.8 | 0.2 |
Kaore i te mohiotia | — | 1.0 | 0.1 |
Tapeke | — | — | 0.5 |
* Kua tohua i roto i te whakamatautau mo te Tepe o te puhui e pa ana ki te ondansetron D. |
ko C te kukū, i te mg ia mL, o USP Ondansetron Hydrochloride RS i roto i te whakaritenga Paerewa;a ko rU me rS nga waahi teitei i whiwhi mai i te whakaritenga Whakamaatau me te whakaritenga Paerewa.
Tikanga 1: I muri i te tauhohenga o 2-Bromoaniline me1,3-Cyclohexanedione, ka hangaia te tetrahydrocarbazole derivative, ka whiwhi te pūhui (III) ma te urupare ki te dimethylamine me te diformaldehyde, me te whakauru i te dimethylaminomethyl i te 2-turanga.3.80G o te pūhui (III) i tauhohehia ki te methyl iodide ki te hoatu 5.72g o te pūhui (IV) mā te quaternizing i te roopu amino mekameka taha i te whakauru i te roopu methyl i te turanga 9. 2.0g o te pūhui (IV) me te 2-methyl-1h -imidazole i tauhohe i roto i te dimethylformamide me te whakaoho i te 95 ℃.Ki te whiwhi 0.60G o Ondansetron.
Tikanga 2: Ko te tauhohenga o te cyclohexanone me te phenylhydrazine i hoatu tetrahydrocarbazole i roto i te 85% hua.Whakarewa i roto i te tetrahydrofuran me te wai, tāpirihia te 2,3 Dropwise i te 0 °c i roto i te hauota, He otinga o 5, 6-tetrachloro-1,4-benzoquinone i te tetrahydrofuran i ohohia kia puta te hua hāora (II) i te 67.4% te hua.Ko te pūhui (II), te waihā, te waikawa pūmāota pūmāota, te paraformaldehyde me te dimethylamine hydrochloride i whakakao tahi.I muri i te maimoatanga, i whiwhihia te hua (V) ma te taapiri i te waikawa maataota ki te acetone me te whakaoho i te 50 ℃.I roto i te 71.7% hua.I tauhohehia te puhui (V) me te 2-methylimidazole ki te wai i te 110 ℃.Ki te whiwhi pūhui (VI) i te 70.9% hua.Ko te huinga (VI), te methyl iodide me te pāhare pāhare pākawa waro i whakakorikoria i te pāmahana rūma tae noa ki te ngaro o te totoka.I ringihia ki te wai, ka whakakorikoria, ka tātarihia, ka horoia ki te wai, ka whakamarohia mai i te methanol kia whiwhi ai te ondansetron i te 57.2% te hua.Whakarewa i roto i te ranunga o te acetone me te wai, Na roto i te taapiri i te waikawa maaota ki te tauhohenga, ka whiwhi te ondansetron hydrochloride dihydrate me te hua o te 92.6%.
Tikanga 3: te pūhui (II), te pāhare pāporo warowaihā, te acetone me te dimethyl sulfate i whakakorikoria i te pāmahana rūma.I whiwhihia te kohinga (VII) i roto i te hua o te 91%.I rewa te puhui (VII) ki te waiwaro me te ranunga o te paraformaldehyde tangata me te dimethylamine hydrochloride i tapirihia ki etahi wahanga i raro i te reflux.Refluxing.I muri i te maimoatanga, ka whiwhi te pūhui (VIII) i roto i te 67% hua.(Viii) ka rewa ki te waiwaro waiwaro, hauwai hauwai, tona hauwai.Ka tāpirihia te waihāhā ki te wai, ā, ka tāpirihia te 2 ki te 50 ℃.Methylimidazole, refluxing ondansetron, hua 70%.I rewa te reira i roto i te isopropanol, te wai me te waikawa pūmāota pūmāota, me te oho i te pāmahana rūma ki te whiwhi ondansetron hydrochloride dihydrate i roto i te tukua o 90.5%.