Ondansetron Hydrochloride Dihydrate CAS 103639-04-9 Assay 98.0~102.0%

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Ingoa matū: Ondansetron Hydrochloride Dihydrate

CAS: 103639-04-9

Whakamātautau: 98.0 ~ 102.0% (Kua tātaihia i runga i te kaupapa anhydrous)

Te ahua: Paura Tioataata Maama ranei

He Antagonist Serotonin (5-HT3) Receptor Antagonist.Whakahau

Whakapā: Takuta Alvin Huang

Pūkoro/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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Hua e Pa ana

Tohu Hua

Whakaahuatanga:

Ko Shanghai Ruifu Chemical te kaihanga matua o Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9) me te kounga teitei.Ka taea e Ruifu te tuku i te ao, te utu whakataetae, te ratonga pai, te iti me te rahinga e waatea ana.Hokona Ondansetron Hydrochloride Dihydrate,Please contact: alvin@ruifuchem.com

Takawaenga e pa ana:

Ngā Āhuatanga matū:

Ingoa matū Ondansetron Hydrochloride Dihydrate
Nga kupu taurite Ondansetron HCl Dihydrate;1,2,3,9-Tetrahydro-9-Methyl-3-[(2-Methyl-1H-imidazol-1-yl)methyl]-4H-Carbazol-4-one Hydrochloride Dihydrate;Emeset;GR 38032 Hydrochloride Dihydrate;SN 307 Hydrochloride Dihydrate;GR 3832 HCl 2H2O;SN-37 HCl 2H2O;NSC665799 HCl 2H2O
Tūnga Taonga Kei roto i nga taonga, Tauine Aromoni
Tau CAS 103639-04-9 (Dihydrate)
CAS RN e pa ana 99614-02-5 (Turanga) & 99614-01-4 (Anhydrous)
Tātai rāpoi C18H19N3O·HCl·2H2O
Taumaha rāpoi 365.86 g/mol
Iwi Whakarewa 176.0 ki te 180.0 ℃
Tairongo Te werawera
Wairewa wai Wairewa ki te wai (>5 mg/ml)
Rokiroki Temp. Wahi Matao me te maroke (2~8℃)
COA & MSDS Kei te waatea
Waitohu Ruifu Chemical

Whakatakotoranga:

Nga taonga Nga Paerewa Tirotiro Hua
Te ahua Ma ki te Paura Tioata-White Ka tutuki
Tautuhinga    
1. UV Max 209, 248, 267, 310nm Kua whai tohu
2. IR tūāwhiorangi He rite ki te Hanganga Kua whai tohu
3. Whakahāweatanga o te Chloride Tauhohenga Whakamua Kua whai tohu
Wai na Karl Fischer 9.0~10.5% 9.7%
Te toenga i runga i te mura ≤0.10% 0.03%
Konga Taamaha (Pb) ≤10ppm <10ppm
Ondansetron Pūhui Pānga C ≤0.20% 0.09%
Ondansetron Pānga pūhui D ≤0.10% 0.04%
Imidazole ≤0.20% 0.02%
2-Methylimidazole ≤0.20% 0.02%
Ondansetron Pānga Puhui A ≤0.20% 0.05%
Ētahi atu poke takitahi Unknown ≤0.10% 0.07%
Nga poke katoa ≤0.50% 0.29%
Wairewa toenga    
Ewaro ≤5000ppm 240ppm
Te whakamatautau 98.0~102.0% (Kua tātaihia i runga i te waikore) 99.81%
Whakamutunga Kua whakamatauria te hua me te whai ki nga whakaritenga

Mōkī/Rokiroki/Te tuku:

Mōkī:Pounamu, Peeke konumohe konumohe, 25kg / Cardboard Drum, kia rite ranei ki te hiahia a te kaihoko.
Tikanga Rokiroki:Rokiroki i roto i te ipu kati kati.Rokiroki i roto i te whare putunga hauhautanga, maroke (2~8 ℃) me te hau pai kia matara atu i nga matū hotokore.Tiaki i te marama me te makuku.
Tukunga:Tukuna ki te ao ma te rangi, ma te FedEx / DHL Express.Whakaratohia te tuku tere me te pono.

Painga:

Rawa Rawa: Rawa rawa nga whakaurunga me nga tohunga hangarau

Ratonga Ngaio: Kotahi te ratonga hoko mutu

Mōkī OEM: Moeke ritenga me te tapanga e waatea ana

Tukunga Tere: Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku

Whakapumau: Kia mau tonu nga taonga e tika ana

Tautoko Hangarau: Kei te waatea te otinga hangarau

Ratonga Hangarau Ritenga: Mai i te karamu ki te kirokaramu

Kounga Teitei: Kua whakaritea he punaha whakapumautanga kounga

FAQ:

Me pehea te hoko?Whakapā maiDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 tau te wheako?Neke atu i te 15 tau o matou wheako ki te hanga me te kaweake i te whānuitanga o nga momo takawaenga rongoa kounga teitei, matū pai ranei.

Nga maakete matua?Hokona ki te maakete kaainga, Amerika Te Tai Tokerau, Uropi, Inia, Korea, Hapani, Ahitereiria, aha atu.

Nga painga?Ko te kounga teitei, te utu utu, nga ratonga ngaio me te tautoko hangarau, te tuku tere.

KoungaWhakapumautanga?Pūnaha whakahaere kounga tino.Ko nga taputapu ngaio mo te tātari ko te NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.

Tauira?Ko te nuinga o nga hua e whakarato ana i nga tauira kore utu mo te aromatawai kounga, me utu nga utu kaipuke e nga kaihoko.

Te arotake a wheketere?Nau mai te arotake wheketere.Whakaritea he hui i mua.

MOQ?Kaore he MOQ.Ka whakaaetia te ota iti.

Wā Tukunga? Mena kei roto i nga taonga, e toru nga ra ka whakamanahia te tuku.

Te kawe waka?Ma te Express (FedEx, DHL), ma te Air, ma te Moana.

Tuhinga?I muri i te ratonga hokohoko: COA, MOA, ROS, MSDS, me etahi atu ka taea te whakarato.

Whakaritenga Whakaritenga?Ka taea te whakarato ratonga whakahiato ritenga kia pai ai to hiahia rangahau.

Nga tikanga utu?Ko te nama Proforma ka tukuna tuatahi i muri i te whakapumautanga o te ota, ka kohia o maatau korero peeke.Te utu ma te T/T (Telex Transfer), PayPal, Western Union, etc.

103639-04-9 - Morearea me te Haumaru:

Waehere Morearea
R25 - He paitini ki te horomia
R36/37/38 - He whakapataritari ki nga kanohi, te punaha manawa me te kiri.
Whakaahuatanga Haumaru
S45 - Ki te aituā, ki te kore koe e pai, rapua he tohutohu hauora (whakaatuhia te tapanga ina taea.)
S37/39 - Kia mau nga karapu tika me te whakamarumaru kanohi/kanohi
S26 - Mena ka pa ki nga kanohi, horoi tonu ki te nui o te wai me te rapu tohutohu hauora.
UN ID UN 2811 6.1/PG 3
WGK Tiamana 3
RTECS FE6375500
Waehere HS 29339900
Akomanga morearea 6.1(a)
Roopu Tapaki II

103639-04-9 - Taupānga:

Ko te Ondansetron Hydrochloride Dihydrate (CAS: 103639-04-9) he kaitakawaenga kaikawe rerotonin (5-HT3) motuhake.Whakahau.Ka whakamahia te Ondansetron Hydrochloride Dihydrate ki te aukati i te nausea me te ruaki ka puta mai pea i te pokanga, te chemotherapy mate pukupuku, te maimoatanga radiation ranei.Ko nga kaiwhaiwhai 5-HT3 i roto i te Ondansetron ko nga raau taero tuatahi e whakamahia ana ki te rongoa me te aukati i te nausea me te ruaki i puta mai i te chemotherapy-induced nausea me te ruaki, na roto i te aukati i nga mahi a nga matū i roto i te tinana.He pai ake te whaihua i te metoclopramide me te iti ake o te whakamaarama i te cyclizine me te droperidol ranei.Heoi, he iti noa te pa ki te ruaki na te mate nekehanga.Ka taea te hoatu ma te mangai, ma te werohia ki roto i te uaua, ki te uaua ranei.

Ko te Ondansetron me te Granisetron, Dolasetron e toru nga rongoa rongoa e whakamahia ana e te haumanu, ko te ondansetron he kaikawe kaikawe serotonin (5-HT3) ka taea te huri me te whiriwhiri, mo te α1, α2, β1, β2-adrenergic receptors me te histamine H1, H2 receptors. he iti noa te paanga, mo nga kaiwhakawhiwhi H, nga kaiwhakawhiwhi dopaminergic pokapū me te peripheral, kare he antagonistic, ka taea e ia te pehi i te chemotherapy me te radiotherapy-induced nausea me te ruaki.Ki te whakatauritea ki te metoclopramide, he kaha ake tona paanga antiemetic me te kore he tauhohenga extrapyramidal.Mo te ruaki na te cisplatin, te cyclophosphamide, te doxorubicin, me etahi atu ka taea te whakaputa tere me te kaha antiemetic.He pai mo te maimoatanga o te nausea me te ruaki na te cytotoxic chemotherapy me te whakamaarama radiation, engari mo te aukati me te maimoatanga o te nausea me te ruaki i puta mai i nga pokanga.Ka mahi a Ondansetron hei waahi whakawhiti i waenga i te nerve afferent visceral e whakahohehia ana i roto i te waahanga gastrointestinal me te pokapū ruaki i roto i te taurakira, e arahi ana ki nga nekehanga o te diaphragm me nga uaua puku.Ka taea e te whakamaarama me te whakamaarama iraruke te tuku i te 5-HT intestinal me te whakaihiihi i te nerve vagus e te kaiwhakawhiwhi 5-HT3, ka puta te ruaki.Ko tenei hua ka aukati i te ahua o te hurihanga, i te wa ano ka aukati i te ruaki i puta mai i te mahi matua.Ko te tikanga mo te nausea me te ruaki i muri i te mahi kaore i te mohiotia.Ko te Ondansetron me te dexamethasonecan ka taea te whakarei ake i te paanga anti-emetic.

103639-04-9 - Painga taha:

Ko tenei ka puta te rere o te afferent vagal, ka puta te ruaki.I roto i te here ki nga kaiwhakawhiwhi 5-HT3, ka aukati te ondansetron i te whakaongaonga o te serotonin, na reira ka ruaki, i muri i nga whakaoho emetogenic penei i te cisplatin.Ko te mamae o te mahunga te tino korero kino o enei rongoa.

103639-04-9 - Kōtaha Haumaru:

He paihana na roto i te ara whakaroto.Human systemic effects by intravenous route: jaundice.Ina whakamahana ki te pirau, ka puta nga kohu paitini o NOx.

103639-04-9 - Rongoa me nga maimoatanga kararehe:

Ka whakamahia hei rongoa i te wa e kore e whai hua nga rongoa rongoa tikanga, penei i te wa e whakahaere ana i te cisplatin, mo etahi atu take o te ruaki kore e taea.Ko te whakamahinga o te ondansetron i roto i nga ngeru he ahua tautohetohe, ko etahi e kii ana kia kaua e whakamahia ki tenei momo.

Whakawhanaungatanga raau taero Ko nga taunekeneke kino pea me etahi atu raau taero.

103639-04-9 - USP35 Paerewa:

Ko te Ondansetron Hydrochloride he iti iho i te 98.0 ōrau me te kore e neke ake i te 102.0 ōrau o te C18H19N3O·HCl, kua tātaihia i runga i te kaupapa anhydrous.
Te takai me te rokiroki-Whakaorangia i roto i nga ipu kikii, marama-ātete.Toa i te 25, ka whakaaetia nga haerenga i waenga i te 15me te 30.
Paerewa Tohutoro USP <11>-
USP Ondansetron Hydrochloride RS
USP Ondansetron Pūhui Pātahi A RS
3[(Dimethylamino)methyl]-1,2,3,9-tetrahydro-9-methyl-4H-carbazol-4-one.
USP Ondansetron Resolution Mixture RS
Ondansetron hydrochloride he āhua 0.4% w/w o ngā pūhui e rua ondansetron pā ana A me te 6,6¢-methylene bis-[(1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-) imidazol-1-yl)-methyl]-4H-carbazol-4-one)]
USP Ondansetron Pūhui Pānga C RS
1,2,3,9-Tetrahydro-9-methyl-4H-carbazol-4-one.
USP Ondansetron Pūhui Pānga D RS
1,2,3,9-Tetrahydro-9-methyl-3-methylene-4H-carbazol-4-one.
Tautuhinga-
A: Whakangao Infrared <197M>.
B: Whakarewahia te 20 mg ki te 2 mL o te wai, tāpirihia te 1 mL o te waikawa nitric 2 M, ka tātari: ka whakautu te filtrate ki te whakamatautau mo te Chloride <191>.
Wai, Tikanga Ia <921>: i waenganui i te 9.0% me te 10.5%.
Te toenga i runga i te mura <281>: kaua e neke ake i te 0.1%.
Tepe o te puhui hono ondansetron D-
Wāhanga pūkoro- Whakapaia he ranunga kua tātarihia, kua whakahekehia hoki o te 0.02 M pāhare pāporo phosphate (i whakaritea i mua me te 1 M konutai waihā ki te pH o 5.4) me te acetonitrile (80:20).Whakaritea nga whakarereketanga mehemea e tika ana (tirohia te Whakaaetanga Pūnaha i raro i te Chromatography <621>).
Wairewa Paerewa-Warekahia te rahinga tika o te USP Ondansetron Related Compound D RS i te wahanga Waea Waea, ka waimeha ine ine, me te hikoi mena e tika ana, me te Waa Waea Pukoro kia whiwhi ai i te otinga e mohiotia ana he 0.4 µg ia mL.
Te otinga pai o te punaha-Warekahia nga rahinga e tika ana mo te USP Ondansetron Related Compound D RS me te USP Ondansetron Related Compound C RS i roto i te Waa Waea Waea Waea Waea Waea Waea Waea Waea Waea Waea Waea Waea Waea Waea Waea M me te 1 µg ia mL.
Te otinga whakamatautau-Whakawhitihia te 50 mg o te Ondansetron Hydrochloride, i tika te pauna, ki te 100-mL ipu pukapuka, memeha ki roto ka waimeha ki te wahanga Waea pūkoro ki te rōrahi, ka uru.
Pūnaha Chromatographic (tirohia te Chromatography <621>)-Ko te chromatograph wai he mea whakakakahu ki te kaitirotiro 328-nm me te pou 4.6-mm × 25-cm kei roto te whakakakahu L10.Ko te tere rere he 1.5 mL ia meneti.Chromatograph te otinga pai o te Pūnaha, me te tuhi i nga whakautu teitei e kiia ana mo te Tikanga: ko nga wa pupuri e pa ana ki te 0.8 mo te ondansetron e pa ana ki te C me te 1.0 mo te ondansetron e pa ana D;me te taumira, R, i waenga i te ondansetron ondansetron compound C me ondansetron related compound D kaua e iti iho i te 1.5.Chromatograph te otinga Paerewa, me te tuhi i nga whakautu tihi e kiia ana mo te Tikanga: ko te pai o te pou ka whakatauhia mai i te tihi tātari kaua e iti iho i te 400 pereti ariā;me te inenga paerewa mo nga werohanga tukurua kaua e neke ake i te 2.0%.
Tikanga- Me werohia nga pukapuka rite (mo te 20 µL) o te otinga Paerewa me te otinga Whakamatau ki roto i te chromatograph, tuhia nga chromatograms, me te ine i nga whakautu mo nga tihi nui.Tātaihia te ōrau o te pūhui pātahi ondansetron D i te wahanga o te Ondansetron Hydrochloride i tangohia e te tātai:
10,000(C/W)(rU / rS)
ko C te kukū, i te mg ia mL, o te USP Ondansetron Related Compound D RS i roto i te otinga Paerewa;Ko W te taumaha, i te mg, o Ondansetron Hydrochloride i tangohia hei whakarite i te otinga Whakamatau;a ko rU me rS nga waahi tihi ka puta mai i te otinga Whakamatau me te otinga Paerewa, ia: kaua e neke ake i te 0.10% ka kitea.
Pure Chromatographic-
tikanga i-
Wairewa Whakatau-Whakarewahia te rahinga o te USP Ondansetron Resolution Mixture RS i roto i te methanol, me te waimeha ine ine, me te hikoi ki te tika, me te mewaro kia whiwhi ai i tetahi otinga e mohiotia ana ko te 12.5 mg ia mL.
Rongonga Paerewa-Warekahia te rahinga tika o te USP Ondansetron Hydrochloride RS ki te methanol, ka uru kia whiwhi ai i tetahi otinga e mohiotia ana he 0.25 mg ia mL.Me waimeha ine tenei otinga ki te methanol kia whiwhi ai i nga otinga Paerewa, kua tohua i raro nei ma te reta, me nga tito e whai ake nei:

otinga paerewa Dilution Kukū (µg RS ia mL) Te ōrau (%, hei whakatairite ki te tauira whakamātautau)
A (1 i roto i te 5) 50 0.4
B (1 i roto i te 10) 25 0.2
C (1 i roto i te 20) 12.5 0.1

Wairewa Whakamatau-Whakarewahia te rahinga tika o te Ondansetron Hydrochloride ki te methanol kia whiwhi ai i te otinga he 12.5 mg ia mL.Tikanga-Hoatu wehea te 20 µL o te otinga Whakamatau, 20 µL o ia otinga Paerewa, me te 20 µL o te otinga Whakatau ki tetahi pereti chromatographic paparanga angiangi (tirohia te Chromatography621) kua whakakikoruatia ki te paparanga 0.25-mm o te ranunga chromatographic silica gel.Whakawhanakehia te chromatogram i roto i te punaha whakarewa he ranunga o te chloroform, ethyl acetate, methanol, me te ammonium hydroxide (90:50:40:1) tae noa ki te neke o te mua whakarewa ki te toru hauwha o te roa o te pereti.Tangohia te pereti mai i te ruma, tohuhia te whakarewa ki mua, ka tuku kia mimiti te whakarewa.Tirohia te pereti i raro i te rama UV roangaru-poto: ka kitea te otinga o nga wahanga e toru o te waahi otinga Whakatau.Whakatauritea te kaha o nga waahi tuarua ka kitea i roto i te chromatogram o te otinga Whakamatau me era o nga waahi matua i roto i nga chromatograms o nga otinga Paerewa: tetahi waahi tuarua mai i te chromatogram o te otinga Whakamatau he uara RF e rite ana ki tera o te tuarua o runga. ko te waahi o te otinga Whakatau kaore i te nui ake, i te kaha ake ranei i te waahi matua i riro mai i te otinga Paerewa A (0.4%);a kaore he waahi tuarua mai i te chromatogram o te otinga Whakamatau ka nui ake, ka kaha ake ranei i te waahi matua i whiwhi mai i te otinga Paerewa B (0.2%).

tikanga ii-

Wāhanga pūkoro me te Pūnaha Chromatographic-Haere tonu i roto i te Whakatau.
otinga Paerewa-Haere rite whakahaua mo te Whakariterite Paerewa i roto i te Assay.
Whakamātautau otinga-Whakamahia te whakaritenga Assay.
Tikanga-Tukuhia wehe nga pukapuka rite (tata ki te 10 µL) o te otinga Paerewa me te otinga Whakamatau ki te chromatograph, tuhia nga chromatograms, me te ine i nga whakautu teitei.Tātaihia te ōrau o ia poke i te wāhanga o Ondansetron Hydrochloride i tangohia e te tātai:
50,000(C/W)(1/F)(ri / rS)
ko C te kukū, i te mg ia mL, o te USP Ondansetron Hydrochloride RS i roto i te otinga Paerewa;Ko W te taumaha, i te mg, o Ondansetron Hydrochloride i tangohia hei whakarite i te otinga Whakamatau;Ko te F te tauwehe whakautu o nga poke e whakaahuatia ana i te ripanga e whai ake nei;Ko ri te waahi teitei mo ia poke i roto i te otinga Whakamatau;a ko rS te waahi teitei o te ondansetron i riro mai i te otinga Paerewa: e tutuki ana i nga whakaritenga e homai ana i te ripanga e whai ake nei.

Ingoa Pūhui Wā Pupuri Whanaunga Whanaunga
Whakautu
Tauwehe
Tepe (%)
Ondansetron pūhui hono C āhua 0.32 1.2 0.2
Ondansetron pūhui hono D* tata ki te 0.34 0.1
Imidazole tata ki te 0.49 0.3 0.2
2-methylimidazole tata ki te 0.54 0.4 0.2
Ondansetron 1.0
Ondansetron pūhui hono A āhua 1.10 0.8 0.2
Kaore i te mohiotia 1.0 0.1
Tapeke 0.5
* Kua tohua i roto i te whakamatautau mo te Tepe o te puhui e pa ana ki te ondansetron D.
whakamātautau-

Wāhanga pūkoro-Whakaritea he ranunga kua tātarihia me te whakaheke hau o te 0.02 M konutai konutai phosphate (i whakaritea i mua me te 1 M konutai waikawa ki te pH o 5.4) me te acetonitrile (50:50).Whakaritea nga whakarereketanga mehemea e tika ana (tirohia te Whakaaetanga Pūnaha i raro i te Chromatography <621>).
Whakariterite Paerewa-Warekahia te rahinga tika o te USP Ondansetron Hydrochloride RS i roto i te wahanga Waea Mobile, ka waimeha ine ine, me te hikoi mena e tika ana, me te wahanga Waea Waea hei whiwhi otinga e mohiotia ana ko te 90 µg ia mL.
Te otinga pai o te punaha-Wahia nga rahinga tika o te USP Ondansetron Hydrochloride RS me te USP Ondansetron Related Compound A RS ki te wahanga Waea Waea, ka waimeha ine ine, me te hikoi mena e tika ana, me te Waa Waea Waea Pukoro kia whiwhi i te otinga kei roto tata ki te 90 µg ia mL me te 20 µg ia mL , ia.
Te whakarite whakamatautau-Whakawhitihia te 45 mg o te Ondansetron Hydrochloride, i tika te pauna, ki te 50-mL ipu pukapuka, memeha ki roto ka waimeha ki te wahanga Waea pūkoro ki te rōrahi, ka uru.Pipetotia te 5.0 mL o tenei wairewa ki roto i te ipu 50-mL, waimeha ki te wahanga Waea pūkoro ki te rōrahi, ka uru.
Pūnaha Chromatographic (tirohia te Chromatography <621>)-Ko te chromatograph wai he mea taputapu ki te 216-nm pūtiro me te 4.6-mm × 25-cm tīwae kei roto L10 takai.Ko te tere rere he 1.5 mL ia meneti.Chromatograph te otinga pai o te Pūnaha, me te tuhi i nga whakautu teitei i runga i te tohutohu mo te Tikanga: ko nga wa pupuri e pa ana ki te 1.0 mo te ondansetron me te 1.1 mo te ondansetron e pa ana ki te pūhui A;me te taumira, R, i waenga i te ondansetron hono A me te ondansetron kaua e iti iho i te 1.5.Chromatograph te Whakariterite Paerewa, ka tuhi i nga whakautu teitei i runga i te tohutohu mo te Tikanga: kaua e neke ake i te 2.0 te tauwehe hiku;a ko te inenga paerewa mo nga werohanga tukurua kaua e neke ake i te 1.5%.
Tikanga-Tukuhia wehe nga pukapuka rite (e tata ana ki te 10 µL) o te whakaritenga Paerewa me te whakaritenga Whakatau ki te chromatograph, tuhia nga chromatograms, me te ine i nga whakautu mo nga tihi nui.Tātaihia te rahinga, i te mg, o C18H19N3O·HCl i te wahanga o Ondansetron Hydrochloride i tangohia e te tauira:
500C(rU / rS)
ko C te kukū, i te mg ia mL, o USP Ondansetron Hydrochloride RS i roto i te whakaritenga Paerewa;a ko rU me rS nga waahi teitei i whiwhi mai i te whakaritenga Whakamaatau me te whakaritenga Paerewa.

103639-04-9 - Tikanga Whakaputa:

Tikanga 1: I muri i te tauhohenga o 2-Bromoaniline me1,3-Cyclohexanedione, ka hangaia te tetrahydrocarbazole derivative, ka whiwhi te pūhui (III) ma te urupare ki te dimethylamine me te diformaldehyde, me te whakauru i te dimethylaminomethyl i te 2-turanga.3.80G o te pūhui (III) i tauhohehia ki te methyl iodide ki te hoatu 5.72g o te pūhui (IV) mā te quaternizing i te roopu amino mekameka taha i te whakauru i te roopu methyl i te turanga 9. 2.0g o te pūhui (IV) me te 2-methyl-1h -imidazole i tauhohe i roto i te dimethylformamide me te whakaoho i te 95 ℃.Ki te whiwhi 0.60G o Ondansetron.

Tikanga 2: Ko te tauhohenga o te cyclohexanone me te phenylhydrazine i hoatu tetrahydrocarbazole i roto i te 85% hua.Whakarewa i roto i te tetrahydrofuran me te wai, tāpirihia te 2,3 Dropwise i te 0 °c i roto i te hauota, He otinga o 5, 6-tetrachloro-1,4-benzoquinone i te tetrahydrofuran i ohohia kia puta te hua hāora (II) i te 67.4% te hua.Ko te pūhui (II), te waihā, te waikawa pūmāota pūmāota, te paraformaldehyde me te dimethylamine hydrochloride i whakakao tahi.I muri i te maimoatanga, i whiwhihia te hua (V) ma te taapiri i te waikawa maataota ki te acetone me te whakaoho i te 50 ℃.I roto i te 71.7% hua.I tauhohehia te puhui (V) me te 2-methylimidazole ki te wai i te 110 ℃.Ki te whiwhi pūhui (VI) i te 70.9% hua.Ko te huinga (VI), te methyl iodide me te pāhare pāhare pākawa waro i whakakorikoria i te pāmahana rūma tae noa ki te ngaro o te totoka.I ringihia ki te wai, ka whakakorikoria, ka tātarihia, ka horoia ki te wai, ka whakamarohia mai i te methanol kia whiwhi ai te ondansetron i te 57.2% te hua.Whakarewa i roto i te ranunga o te acetone me te wai, Na roto i te taapiri i te waikawa maaota ki te tauhohenga, ka whiwhi te ondansetron hydrochloride dihydrate me te hua o te 92.6%.

Tikanga 3: te pūhui (II), te pāhare pāporo warowaihā, te acetone me te dimethyl sulfate i whakakorikoria i te pāmahana rūma.I whiwhihia te kohinga (VII) i roto i te hua o te 91%.I rewa te puhui (VII) ki te waiwaro me te ranunga o te paraformaldehyde tangata me te dimethylamine hydrochloride i tapirihia ki etahi wahanga i raro i te reflux.Refluxing.I muri i te maimoatanga, ka whiwhi te pūhui (VIII) i roto i te 67% hua.(Viii) ka rewa ki te waiwaro waiwaro, hauwai hauwai, tona hauwai.Ka tāpirihia te waihāhā ki te wai, ā, ka tāpirihia te 2 ki te 50 ℃.Methylimidazole, refluxing ondansetron, hua 70%.I rewa te reira i roto i te isopropanol, te wai me te waikawa pūmāota pūmāota, me te oho i te pāmahana rūma ki te whiwhi ondansetron hydrochloride dihydrate i roto i te tukua o 90.5%.

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