Palbociclib CAS 571190-30-2 Purity >99.5% (HPLC) API Factory
Ruifu Chemical Supply Palbociclib Related Intermediates:
Palbociclib CAS 571190-30-2
5-Bromo-2,4-Dichloropyrimidine CAS 36082-50-5
5-Bromo-2-Chloro-N-Cyclopentylpyrimidin-4-Amine CAS 733039-20-8
tert-Butyl 4-(6-Nitropyridin-3-yl)piperazine-1-Carboxylate CAS 571189-16-7
tert-Butyl 4-(6-Amino-3-Pyridyl)piperazine-1-Carboxylate CAS 571188-59-5
6-Bromo-2-Chloro-8-Cyclopentyl-5-Methylpyrido-[2,3-d]pyrimidin-7(8H)-kotahi CAS 1016636-76-2
2-Chloro-8-Cyclopentyl-5-Methyl-8H-Pyrido[2,3-d]pyrimidin-7-one CAS 1013916-37-4
Ingoa matū | Palbociclib |
Nga kupu taurite | PD-0332991;Otava-Bb 1115529;Ibrance |
Tau CAS | 571190-30-2 |
Tūnga Taonga | I roto i te Stock, Production Tauine Up ki Taranata |
Tātai rāpoi | C24H29N7O2 |
Taumaha rāpoi | 447.54 |
Waitohu | Ruifu Chemical |
Tūemi | Whakatakotoranga |
Te ahua | Paura Ma, Paura-Ma ranei |
1H NMR Spectrum | E rite ana ki te Hanganga |
HPLC | E rite ana ki te Hanganga |
Nga Taonga Paanga | |
Te poke takitahi | <0.50% |
Nga poke katoa | <1.00% |
Ngaronga i te whakamaroke | <0.50% |
Te toenga i runga i te mura | <0.10% |
Nga Korewa Taamaha | <10ppm |
Te Maama / Tikanga Tatauria | >99.5% (HPLC) |
Paerewa Whakamatau | Paerewa hinonga |
Whakamahinga | API, I roto i te maimoatanga o te mate pukupuku uma |
Mōkī: Pounamu, Peeke konumohe konumohe, 25kg / Kaata Drum, kia rite ranei ki te hiahia a te kaihoko
Tikanga Rokiroki:Whakaorangia i roto i nga ipu kua hiri ki te waahi makariri me te maroke;Tiaki i te marama me te makuku
Ko te Palbociclib (CAS: 571190-30-2) he aukati cyclin-dependent kinase (CDK) e waatea ana me te mahi antineoplastic pea.Ko Palbociclib te aukati i te kinase 4 (CDK4) me te 6 (CDK6), ka aukati i te phosphorylation pūmua retinoblastoma (Rb) i te timatanga o te wahanga G1 e arahi ana ki te hopu i te huringa pūtau.Ma tenei ka whakakore i te tukuruatanga DNA me te whakaheke i te tipu o nga pūtau puku.Ko Palbociclib te māngai tuatahi o te karaehe rongoa hou o nga aukati kinase e whakawhirinaki ana ki te cyclin.Ka whakawhāiti tēnei pānga i te whakatipu pūtau (te tipu me te wehenga pūtau).Ka whakamahia hei kaihoko antineoplastic mo te mate pukupuku o te uma, metastatic ranei.